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B3EAF3

- SPEA_GEOLS

UniProt

B3EAF3 - SPEA_GEOLS

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciGLOV398767:GH32-1700-MONOMER.
    UniPathwayiUPA00186; UER00284.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:Glov_1675
    OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
    Taxonomic identifieri398767 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002420: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000145595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiB3EAF3.

    Interactioni

    Protein-protein interaction databases

    STRINGi398767.Glov_1675.

    Structurei

    3D structure databases

    ProteinModelPortaliB3EAF3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni282 – 29211Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiIDHYVDG.
    OrthoDBiEOG676Z0R.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3EAF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERWSINESA KVYNLDNWGA DLFSINKKGN ICVHPSSNSK NAIDLRALVD    50
    DLIKRKIKPP ILLRFMDVLQ GRIASINRVF RNAIAENDYP AKYQTFYPIK 100
    VNQQRQVVEA IASYGKRYNI GLEVGSKPEL VAGIAISTGN GLPIICNGYK 150
    DAEYIETVLF ATRVGYNITI VVEKLFELEK IIELAKKTGI RPSLGIRVKL 200
    SSKGTGKWAT SGGEDAKFGL RMSEIMAAIK MLQEADLLDC VNLLHSHIGS 250
    QVTKIDKIKT ALIEAARIYS EMRKLGVNIQ YLDIGGGLGV DYDGSKSSYF 300
    SSVNYTVEEY ANDVIYQIKN ICDEAGVDCP NIISESGRAT VAHYSVLVTN 350
    VLNTNTQNLM PDYEQILEEM EKPAPTVKKL LDIYKSIDRY SLREDYHDTL 400
    QLINEAVSLF NLGYLTLQDR AIAEWLYSKI IKKINSIVEK IKPIPEELQN 450
    FQLALRQTYF ANFSLFQSIP DSWAIDQLFP IMPLQRLGQR PDVMASIADI 500
    TCDSDGEITS FVGENGRSKF LPMHKLKKDE DYYIGFFLIG AYQEILGDLH 550
    NLFGDTNAVH ITFNKKTGYM IDTVINGDAT WETLKYVQYK GPEILKHVRD 600
    NLEKQVAIKK VSIEESSHFI ELLDRTLLGY TYLGE 635
    Length:635
    Mass (Da):71,685
    Last modified:July 22, 2008 - v1
    Checksum:i9165D56672C0CBF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001089 Genomic DNA. Translation: ACD95391.1.
    RefSeqiWP_012469733.1. NC_010814.1.
    YP_001951911.1. NC_010814.1.

    Genome annotation databases

    EnsemblBacteriaiACD95391; ACD95391; Glov_1675.
    GeneIDi6368497.
    KEGGiglo:Glov_1675.
    PATRICi21995027. VBIGeoLov31523_1620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001089 Genomic DNA. Translation: ACD95391.1 .
    RefSeqi WP_012469733.1. NC_010814.1.
    YP_001951911.1. NC_010814.1.

    3D structure databases

    ProteinModelPortali B3EAF3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398767.Glov_1675.

    Proteomic databases

    PRIDEi B3EAF3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD95391 ; ACD95391 ; Glov_1675 .
    GeneIDi 6368497.
    KEGGi glo:Glov_1675.
    PATRICi 21995027. VBIGeoLov31523_1620.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi IDHYVDG.
    OrthoDBi EOG676Z0R.

    Enzyme and pathway databases

    UniPathwayi UPA00186 ; UER00284 .
    BioCyci GLOV398767:GH32-1700-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1151 / DSM 17278 / SZ.

    Entry informationi

    Entry nameiSPEA_GEOLS
    AccessioniPrimary (citable) accession number: B3EAF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3