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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGLOV398767:GH32-1700-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:Glov_1675
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002420 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000145595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiB3EAF3.

Interactioni

Protein-protein interaction databases

STRINGi398767.Glov_1675.

Structurei

3D structure databases

ProteinModelPortaliB3EAF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 29211Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3EAF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERWSINESA KVYNLDNWGA DLFSINKKGN ICVHPSSNSK NAIDLRALVD
60 70 80 90 100
DLIKRKIKPP ILLRFMDVLQ GRIASINRVF RNAIAENDYP AKYQTFYPIK
110 120 130 140 150
VNQQRQVVEA IASYGKRYNI GLEVGSKPEL VAGIAISTGN GLPIICNGYK
160 170 180 190 200
DAEYIETVLF ATRVGYNITI VVEKLFELEK IIELAKKTGI RPSLGIRVKL
210 220 230 240 250
SSKGTGKWAT SGGEDAKFGL RMSEIMAAIK MLQEADLLDC VNLLHSHIGS
260 270 280 290 300
QVTKIDKIKT ALIEAARIYS EMRKLGVNIQ YLDIGGGLGV DYDGSKSSYF
310 320 330 340 350
SSVNYTVEEY ANDVIYQIKN ICDEAGVDCP NIISESGRAT VAHYSVLVTN
360 370 380 390 400
VLNTNTQNLM PDYEQILEEM EKPAPTVKKL LDIYKSIDRY SLREDYHDTL
410 420 430 440 450
QLINEAVSLF NLGYLTLQDR AIAEWLYSKI IKKINSIVEK IKPIPEELQN
460 470 480 490 500
FQLALRQTYF ANFSLFQSIP DSWAIDQLFP IMPLQRLGQR PDVMASIADI
510 520 530 540 550
TCDSDGEITS FVGENGRSKF LPMHKLKKDE DYYIGFFLIG AYQEILGDLH
560 570 580 590 600
NLFGDTNAVH ITFNKKTGYM IDTVINGDAT WETLKYVQYK GPEILKHVRD
610 620 630
NLEKQVAIKK VSIEESSHFI ELLDRTLLGY TYLGE
Length:635
Mass (Da):71,685
Last modified:July 21, 2008 - v1
Checksum:i9165D56672C0CBF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA. Translation: ACD95391.1.
RefSeqiWP_012469733.1. NC_010814.1.
YP_001951911.1. NC_010814.1.

Genome annotation databases

EnsemblBacteriaiACD95391; ACD95391; Glov_1675.
KEGGiglo:Glov_1675.
PATRICi21995027. VBIGeoLov31523_1620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA. Translation: ACD95391.1.
RefSeqiWP_012469733.1. NC_010814.1.
YP_001951911.1. NC_010814.1.

3D structure databases

ProteinModelPortaliB3EAF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398767.Glov_1675.

Proteomic databases

PRIDEiB3EAF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD95391; ACD95391; Glov_1675.
KEGGiglo:Glov_1675.
PATRICi21995027. VBIGeoLov31523_1620.

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.
BioCyciGLOV398767:GH32-1700-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Entry informationi

Entry nameiSPEA_GEOLS
AccessioniPrimary (citable) accession number: B3EAF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2009
Last sequence update: July 21, 2008
Last modified: March 31, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.