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B3E7F6

- PUR9_GEOLS

UniProt

B3E7F6 - PUR9_GEOLS

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciGLOV398767:GH32-2801-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Glov_2760
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002420: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Bifunctional purine biosynthesis protein PurHPRO_1000192977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398767.Glov_2760.

Structurei

3D structure databases

ProteinModelPortaliB3E7F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B3E7F6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKITRALIS VSDKTGIVEL SKALAGYGVE ILSTGGTAKL LRESGLTVKD
60 70 80 90 100
VSEFTGFPEM LDGRVKTLHP KVHGGLLGIR ANAEHQAKMK EHGIEPIDMV
110 120 130 140 150
VVNLYPFEAT VAKPDCTLED AIENIDIGGP TMLRSAAKNN HDVTVLVDAA
160 170 180 190 200
DYAAVLEEMA ANGGAVSAKT NFRLAVKVYQ HTAAYDGAIS NWLGARLGEN
210 220 230 240 250
TDEYPETFTI QVKKAQDLRY GENPHQSAAF YVERGITEPC VSNAVQLQGK
260 270 280 290 300
ELSFNNIIDL DAAIETVKEF TDKPAAVIIK HTNPCGVALG DSPISAYLKA
310 320 330 340 350
RECDPVSAFG GIVGFNRIVD AAAARELTST FLEAVIAPGY DEEALAIFTA
360 370 380 390 400
KKNVRVMQVP LLAGHLQTGY DLKRVVGGLL LQGRDLGMVA ATDCKVMSER
410 420 430 440 450
QPTAQELAAL DFAWRVCKHV KSNAIVFTNA DQTVGIGAGQ MSRVDSSKIA
460 470 480 490 500
VQKALLPIKG TVLASDAFFP FRDGVDAAAE AGVTAIIQPG GSVRDEEVIQ
510
AANEHGMAMV FTNMRHFRH
Length:519
Mass (Da):55,548
Last modified:July 22, 2008 - v1
Checksum:i14731ED400A3E798
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD96473.1.
RefSeqiYP_001952993.1. NC_010814.1.

Genome annotation databases

EnsemblBacteriaiACD96473; ACD96473; Glov_2760.
GeneIDi6367669.
KEGGiglo:Glov_2760.
PATRICi21997195. VBIGeoLov31523_2697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD96473.1 .
RefSeqi YP_001952993.1. NC_010814.1.

3D structure databases

ProteinModelPortali B3E7F6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398767.Glov_2760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD96473 ; ACD96473 ; Glov_2760 .
GeneIDi 6367669.
KEGGi glo:Glov_2760.
PATRICi 21997195. VBIGeoLov31523_2697.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci GLOV398767:GH32-2801-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Entry informationi

Entry nameiPUR9_GEOLS
AccessioniPrimary (citable) accession number: B3E7F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3