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B3E6Y9

- NADK_GEOLS

UniProt

B3E6Y9 - NADK_GEOLS

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Protein

NAD kinase

Gene
nadK, Glov_2681
Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptor By similarity
Binding sitei152 – 1521NAD By similarity
Binding sitei169 – 1691NAD By similarity
Binding sitei171 – 1711NAD By similarity
Binding sitei242 – 2421NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NAD By similarity
Nucleotide bindingi141 – 1422NAD By similarity
Nucleotide bindingi182 – 1876NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciGLOV398767:GH32-2720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Glov_2681
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002420: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285NAD kinaseUniRule annotationPRO_1000120863Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398767.Glov_2681.

Structurei

3D structure databases

ProteinModelPortaliB3E6Y9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiGAEFCLN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B3E6Y9-1 [UniParc]FASTAAdd to Basket

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MKQVAIFAKV HDPRCQGVAS ELVTWLEERK CLPLVDTHLA RHVGYARGLT    50
EKQIRDRAEL VVVLGGDGTL ISVARLFSSR QVPIVGVNLG SLGFLTEITV 100
EQLYPVLEQC LADSHRITER MMLDVTVTRG DQEISHCQVL NDAVINKGAL 150
ARIIELEARV NDDFLTNFKA DGLIISTPTG STGYSLSAGG PIVQPLMKCV 200
LITPICPHTL TNRPIVLSYQ SVIRITVKSS FDEMVYLTLD GQVGVELQEG 250
DCIEVSRAET TTALVTSPEK DYFAILRAKL KWGER 285
Length:285
Mass (Da):31,388
Last modified:July 22, 2008 - v1
Checksum:iB38A3136654F11CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD96394.1.
RefSeqiWP_012470724.1. NC_010814.1.
YP_001952914.1. NC_010814.1.

Genome annotation databases

EnsemblBacteriaiACD96394; ACD96394; Glov_2681.
GeneIDi6368372.
KEGGiglo:Glov_2681.
PATRICi21997037. VBIGeoLov31523_2618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD96394.1 .
RefSeqi WP_012470724.1. NC_010814.1.
YP_001952914.1. NC_010814.1.

3D structure databases

ProteinModelPortali B3E6Y9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398767.Glov_2681.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD96394 ; ACD96394 ; Glov_2681 .
GeneIDi 6368372.
KEGGi glo:Glov_2681.
PATRICi 21997037. VBIGeoLov31523_2618.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi GAEFCLN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci GLOV398767:GH32-2720-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Entry informationi

Entry nameiNADK_GEOLS
AccessioniPrimary (citable) accession number: B3E6Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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