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B3E6Y9

- NADK_GEOLS

UniProt

B3E6Y9 - NADK_GEOLS

Protein

NAD kinase

Gene

nadK

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Proton acceptorUniRule annotation
    Binding sitei152 – 1521NADUniRule annotation
    Binding sitei169 – 1691NADUniRule annotation
    Binding sitei171 – 1711NADUniRule annotation
    Binding sitei242 – 2421NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 682NADUniRule annotation
    Nucleotide bindingi141 – 1422NADUniRule annotation
    Nucleotide bindingi182 – 1876NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGLOV398767:GH32-2720-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Glov_2681
    OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
    Taxonomic identifieri398767 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002420: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285NAD kinasePRO_1000120863Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398767.Glov_2681.

    Structurei

    3D structure databases

    ProteinModelPortaliB3E6Y9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiGAEFCLN.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3E6Y9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQVAIFAKV HDPRCQGVAS ELVTWLEERK CLPLVDTHLA RHVGYARGLT    50
    EKQIRDRAEL VVVLGGDGTL ISVARLFSSR QVPIVGVNLG SLGFLTEITV 100
    EQLYPVLEQC LADSHRITER MMLDVTVTRG DQEISHCQVL NDAVINKGAL 150
    ARIIELEARV NDDFLTNFKA DGLIISTPTG STGYSLSAGG PIVQPLMKCV 200
    LITPICPHTL TNRPIVLSYQ SVIRITVKSS FDEMVYLTLD GQVGVELQEG 250
    DCIEVSRAET TTALVTSPEK DYFAILRAKL KWGER 285
    Length:285
    Mass (Da):31,388
    Last modified:July 22, 2008 - v1
    Checksum:iB38A3136654F11CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001089 Genomic DNA. Translation: ACD96394.1.
    RefSeqiWP_012470724.1. NC_010814.1.
    YP_001952914.1. NC_010814.1.

    Genome annotation databases

    EnsemblBacteriaiACD96394; ACD96394; Glov_2681.
    GeneIDi6368372.
    KEGGiglo:Glov_2681.
    PATRICi21997037. VBIGeoLov31523_2618.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001089 Genomic DNA. Translation: ACD96394.1 .
    RefSeqi WP_012470724.1. NC_010814.1.
    YP_001952914.1. NC_010814.1.

    3D structure databases

    ProteinModelPortali B3E6Y9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398767.Glov_2681.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD96394 ; ACD96394 ; Glov_2681 .
    GeneIDi 6368372.
    KEGGi glo:Glov_2681.
    PATRICi 21997037. VBIGeoLov31523_2618.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi GAEFCLN.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci GLOV398767:GH32-2720-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1151 / DSM 17278 / SZ.

    Entry informationi

    Entry nameiNADK_GEOLS
    AccessioniPrimary (citable) accession number: B3E6Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3