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Protein

NAD kinase

Gene

nadK

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorUniRule annotation1
Binding sitei152NADUniRule annotation1
Binding sitei169NADUniRule annotation1
Binding sitei171NADUniRule annotation1
Binding sitei242NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 68NADUniRule annotation2
Nucleotide bindingi141 – 142NADUniRule annotation2
Nucleotide bindingi182 – 187NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Glov_2681
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208631 – 285NAD kinaseAdd BLAST285

Interactioni

Protein-protein interaction databases

STRINGi398767.Glov_2681.

Structurei

3D structure databases

ProteinModelPortaliB3E6Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiLLWGESP.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B3E6Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQVAIFAKV HDPRCQGVAS ELVTWLEERK CLPLVDTHLA RHVGYARGLT
60 70 80 90 100
EKQIRDRAEL VVVLGGDGTL ISVARLFSSR QVPIVGVNLG SLGFLTEITV
110 120 130 140 150
EQLYPVLEQC LADSHRITER MMLDVTVTRG DQEISHCQVL NDAVINKGAL
160 170 180 190 200
ARIIELEARV NDDFLTNFKA DGLIISTPTG STGYSLSAGG PIVQPLMKCV
210 220 230 240 250
LITPICPHTL TNRPIVLSYQ SVIRITVKSS FDEMVYLTLD GQVGVELQEG
260 270 280
DCIEVSRAET TTALVTSPEK DYFAILRAKL KWGER
Length:285
Mass (Da):31,388
Last modified:July 22, 2008 - v1
Checksum:iB38A3136654F11CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA. Translation: ACD96394.1.
RefSeqiWP_012470724.1. NC_010814.1.

Genome annotation databases

EnsemblBacteriaiACD96394; ACD96394; Glov_2681.
KEGGiglo:Glov_2681.
PATRICi21997037. VBIGeoLov31523_2618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA. Translation: ACD96394.1.
RefSeqiWP_012470724.1. NC_010814.1.

3D structure databases

ProteinModelPortaliB3E6Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398767.Glov_2681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD96394; ACD96394; Glov_2681.
KEGGiglo:Glov_2681.
PATRICi21997037. VBIGeoLov31523_2618.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiLLWGESP.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_GEOLS
AccessioniPrimary (citable) accession number: B3E6Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.