B3E6Y0 (B3E6Y0_GEOLS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP-Rule MF_00712
EC=1.4.4.2 HAMAP-Rule MF_00712

Alternative name(s):
Glycine cleavage system P-protein subunit 1 HAMAP-Rule MF_00712
Glycine decarboxylase subunit 1 HAMAP-Rule MF_00712

Gene names

Name:	gcvPA HAMAP-Rule MF_00712
Ordered Locus Names:	Glov_2672 EMBL ACD96385.1

Organism

Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) [Complete proteome] [HAMAP] EMBL ACD96385.1

Taxonomic identifier

398767 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter › Geobacter lovleyi

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00712 SAAS SAAS023010
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily. HAMAP-Rule MF_00712

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP-Rule MF_00712 SAAS SAAS023010 EMBL ACD96385.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3E6Y0 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 0B914F36A1A9F165	FASTA	448	47,741
	10 20 30 40 50 60 MNTSHYCPHT PEEIQEMLAA IGVSSVEELF APIPAELRCS TFNLPVGMSE FETYARLQSV 70 80 90 100 110 120 AADNNQNLSL FIGGGFYDHI IPAAVDHLSG RAEFYTAYTP YQPECSQGTL QALFEYQTAI 130 140 150 160 170 180 CRLTGLDVSN ASLYDGATGL AEAALMAMRA TNRTKVVVDG CVSPIARQVL ATYLSNQDAE 190 200 210 220 230 240 LVELPPLDGL LNREDLAKQL DANTAAVLVQ YPNVFGGVED FSGLADQAHA AGALLVTAVY 250 260 270 280 290 300 PVALGILKSP GELGADIAVG DGQSLGNPLS FGGPSFGFIA ARKAHIRNMP GRIVGETVDK 310 320 330 340 350 360 NGKRGFVLTL QAREQHIKRH KATSNICSNQ SLCALRGLIF LAAIGKQGLA DLARLNRDKA 370 380 390 400 410 420 EYAKACLAKL PGVVVLQTAP TFNEFTISLP KPAEAVVAAL LDKGIAAGMP LGRFYTGSEN 430 440 MLVVTVTEKR SKKEIDQLVK ALEVALCN

References

[1]

"Complete sequence of chromosome of Geobacter lovleyi SZ." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Sung Y., Fletcher K.E., Ritalahti K.M., Loeffler F.E., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001089 Genomic DNA. Translation: ACD96385.1.
RefSeq	YP_001952905.1. NC_010814.1.
3D structure databases
ProteinModelPortal	B3E6Y0.
ModBase	Search...
Protein-protein interaction databases
STRING	398767.Glov_2672.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD96385; ACD96385; Glov_2672.
GeneID	6367720.
KEGG	glo:Glov_2672.
PATRIC	21997019. VBIGeoLov31523_2609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HOG000132025.
KO	K00282.
OMA	MYDGASA.
ProtClustDB	PRK00451.
Enzyme and pathway databases
BioCyc	GLOV398767:GH32-2792-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00712. GcvPA.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
PIRSF	PIRSF006815. GcvPA. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B3E6Y0_GEOLS

Accession

Primary (citable) accession number: B3E6Y0

Entry history

Integrated into UniProtKB/TrEMBL:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)