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B3E600 (ADE_GEOLS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:Glov_1001
OrganismGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) [Complete proteome] [HAMAP]
Taxonomic identifier398767 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Adenine deaminase HAMAP MF_01962
PRO_1000128848

Sites

Active site2071Proton donor By similarity
Metal binding241Zinc; catalytic By similarity
Metal binding261Zinc; catalytic By similarity
Metal binding2041Zinc; catalytic By similarity
Metal binding2851Zinc; catalytic By similarity
Binding site2861Substrate By similarity
Site2281Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B3E600 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 14FD3AFC0081076D

FASTA34939,130
        10         20         30         40         50         60 
MNLTNIPRQA LPELLCRMPK AELHIHIEGS LEPELIFALA ERNRLQLAYP TIESLRAAYA 

        70         80         90        100        110        120 
FTNLQSFLDI YYAGASVLQT EQDFFDMAWA YLLRAKADNV VHAEIFFDPQ THTARGIPFA 

       130        140        150        160        170        180 
TIINGLDRAI QQGRNELGIS AALILCFLRH LTEADAFTVL EEALPFRDKF IGVGLDSGEK 

       190        200        210        220        230        240 
GNPPEKFSRV FARCRELGLR LVAHAGEEGT AEYIWHALDL LQAERIDHGV HCLDDPQLVT 

       250        260        270        280        290        300 
RLVQQQVPLT VCPLSNVKLR VFPDLAAHNI ARLLACGIRA TINSDDPAYF GGYLNQNYLE 

       310        320        330        340 
TFAALPELGA AEAYQLARNS FEASFVDAEV KAGWIRELDQ FFQQQCDKI

« Hide

References

[1]"Complete sequence of chromosome of Geobacter lovleyi SZ."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Sung Y., Fletcher K.E., Ritalahti K.M., Loeffler F.E., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001089 Genomic DNA. Translation: ACD94724.1.
RefSeqYP_001951244.1. NC_010814.1.

3D structure databases

ProteinModelPortalB3E600.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3E600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6367699.
GenomeReviewsGene locus Glov_1001 in contig CP001089_GR.
KEGGglo:Glov_1001.
PATRIC21993691. VBIGeoLov31523_0968.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMAFGGYVDD.
ProtClustDBCLSK2324783.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_GEOLS
AccessionPrimary (citable) accession number: B3E600
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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