B3E4H8 (LPXB_GEOLS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	Glov_0767

Organism

Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) [Complete proteome] [HAMAP]

Taxonomic identifier

398767 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Lipid-A-disaccharide synthase HAMAP MF_00392		PRO_1000123050

Sequences

	Sequence		Length	Mass (Da)
	B3E4H8 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 482BF35BC063C6D1	FASTA	383	41,770
	10 20 30 40 50 60 MAVGRPKRVM IVAGEASGDI YGAGLVRAVQ AADPAFSFFG IGGPRMREAG CETLVDSADM 70 80 90 100 110 120 AVVGLVEVLK HFDVIAAAFL KLKKILLEDP PDLLILIDYP GFNLRLGKVA KKAGVKVLYY 130 140 150 160 170 180 ISPQIWAWRQ GRVKKIKRLV DHMAVILPFE VPFYEQAGVP VSFVGHPMAD LVEVSLTRDQ 190 200 210 220 230 240 AATSFGLDTS RQIVGLFPGS RRSEVSRLLP TILEAARLLQ QCLPGLQFVL PLASTLSDDD 250 260 270 280 290 300 LAPWLEGCEL PITVTRDRIH DLMRACDAVI SVSGTVTLEI ALVGTPLVII YKLSPLTFQL 310 320 330 340 350 360 AKRLVKVEHI GLCNIVAGET VARELIQEEA SPEQIAGEIG RLLRDAEYNT AFRERLTHVR 370 380 ERLGGGGADR RMAGLVLSMV EQS

References

[1]

"Complete sequence of chromosome of Geobacter lovleyi SZ." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Sung Y., Fletcher K.E., Ritalahti K.M., Loeffler F.E., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001089 Genomic DNA. Translation: ACD94493.1.
RefSeq	YP_001951013.1. NC_010814.1.
3D structure databases
ProteinModelPortal	B3E4H8.
ModBase	Search...
Protein-protein interaction databases
STRING	B3E4H8.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6367254.
GenomeReviews	Gene locus Glov_0767 in contig CP001089_GR.
KEGG	glo:Glov_0767.
PATRIC	21993227. VBIGeoLov31523_0737.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	PRK00025.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_GEOLS

Accession

Primary (citable) accession number: B3E4H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program