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B3E4H8

- LPXB_GEOLS

UniProt

B3E4H8 - LPXB_GEOLS

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciGLOV398767:GH32-776-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Glov_0767
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002420: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000123050Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398767.Glov_0767.

Structurei

3D structure databases

ProteinModelPortaliB3E4H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B3E4H8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVGRPKRVM IVAGEASGDI YGAGLVRAVQ AADPAFSFFG IGGPRMREAG
60 70 80 90 100
CETLVDSADM AVVGLVEVLK HFDVIAAAFL KLKKILLEDP PDLLILIDYP
110 120 130 140 150
GFNLRLGKVA KKAGVKVLYY ISPQIWAWRQ GRVKKIKRLV DHMAVILPFE
160 170 180 190 200
VPFYEQAGVP VSFVGHPMAD LVEVSLTRDQ AATSFGLDTS RQIVGLFPGS
210 220 230 240 250
RRSEVSRLLP TILEAARLLQ QCLPGLQFVL PLASTLSDDD LAPWLEGCEL
260 270 280 290 300
PITVTRDRIH DLMRACDAVI SVSGTVTLEI ALVGTPLVII YKLSPLTFQL
310 320 330 340 350
AKRLVKVEHI GLCNIVAGET VARELIQEEA SPEQIAGEIG RLLRDAEYNT
360 370 380
AFRERLTHVR ERLGGGGADR RMAGLVLSMV EQS
Length:383
Mass (Da):41,770
Last modified:July 22, 2008 - v1
Checksum:i482BF35BC063C6D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD94493.1.
RefSeqiYP_001951013.1. NC_010814.1.

Genome annotation databases

EnsemblBacteriaiACD94493; ACD94493; Glov_0767.
GeneIDi6367254.
KEGGiglo:Glov_0767.
PATRICi21993227. VBIGeoLov31523_0737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD94493.1 .
RefSeqi YP_001951013.1. NC_010814.1.

3D structure databases

ProteinModelPortali B3E4H8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398767.Glov_0767.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD94493 ; ACD94493 ; Glov_0767 .
GeneIDi 6367254.
KEGGi glo:Glov_0767.
PATRICi 21993227. VBIGeoLov31523_0737.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci GLOV398767:GH32-776-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Entry informationi

Entry nameiLPXB_GEOLS
AccessioniPrimary (citable) accession number: B3E4H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3