B3E2K5 (KTHY_GEOLS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	Glov_1946

Organism

Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) [Complete proteome] [HAMAP]

Taxonomic identifier

398767 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter › Geobacter lovleyi

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Thymidylate kinase HAMAP-Rule MF_00165		PRO_1000123573
Regions
	Nucleotide binding	7 – 14	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B3E2K5 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: E94F3B246B3FD0E7	FASTA	212	22,693
	10 20 30 40 50 60 MFITFEGIEG CGKSTQIALL AASLQQAGQR VLLTREPGGC PIADQIRSVL LDAANTALVP 70 80 90 100 110 120 MAELMLYAAS RAQHLAEVVS PALAEGVIVL CDRFSDATRA YQSFGRGIDR QVIETLNSLA 130 140 150 160 170 180 CDGISPDLTV LLDCPVETGL GRARQRIDST SGPREERFEL ESLAFHQRVR DGYLQLAAEE 190 200 210 PGRFVIVDAT VQPAQVASAI SDAVLSRLAV PV

References

[1]

"Complete sequence of chromosome of Geobacter lovleyi SZ." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Sung Y., Fletcher K.E., Ritalahti K.M., Loeffler F.E., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001089 Genomic DNA. Translation: ACD95662.1.
RefSeq	YP_001952182.1. NC_010814.1.
3D structure databases
ProteinModelPortal	B3E2K5.
ModBase	Search...
Protein-protein interaction databases
STRING	398767.Glov_1946.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD95662; ACD95662; Glov_1946.
GeneID	6369292.
KEGG	glo:Glov_1946.
PATRIC	21995579. VBIGeoLov31523_1888.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0125.
HOGENOM	HOG000229078.
KO	K00943.
OMA	ITLEGPE.
ProtClustDB	CLSK924585.
Enzyme and pathway databases
BioCyc	GLOV398767:GH32-1979-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_GEOLS

Accession

Primary (citable) accession number: B3E2K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	July 22, 2008
Last modified:	May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program