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B3E262

- B3E262_GEOLS

UniProt

B3E262 - B3E262_GEOLS

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, Glov_3462
Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721Substrate By similarityUniRule annotation
Binding sitei212 – 2121Substrate; via amide nitrogen By similarityUniRule annotation
Metal bindingi219 – 2191Manganese By similarityUniRule annotation
Binding sitei219 – 2191Substrate By similarityUniRule annotation
Metal bindingi239 – 2391Manganese; via tele nitrogen By similarityUniRule annotation
Binding sitei261 – 2611Substrate By similarityUniRule annotation
Active sitei263 – 2631 By similarityUniRule annotation
Metal bindingi290 – 2901Manganese By similarityUniRule annotation
Binding sitei382 – 3821GTP By similarityUniRule annotation
Binding sitei413 – 4131GTP By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi262 – 2676GTP By similarityUniRule annotation
Nucleotide bindingi506 – 5094GTP By similarityUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. kinase activity Source: UniProtKB-KW
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, KinaseImported, Lyase, Transferase

Keywords - Biological processi

GluconeogenesisUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

BioCyciGLOV398767:GH32-3514-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Alternative name(s):
Phosphoenolpyruvate carboxylase
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:Glov_3462Imported
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)Imported
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002420: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi398767.Glov_3462.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni380 – 3823Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3E262-1 [UniParc]FASTAAdd to Basket

« Hide

MSYEVKNEQL KAWVAEVEAM CEPANIHWCD GSQEEYDRLC GQMVESGTFR    50
KLNPEKRPNS YLAFSDPIDV ARVEDRTFIC SLNKQDAGPT NNWVAPKEMK 100
ETLKGLFKGC MKGRTMYVIP FSMGPLGSNI AKIGVEITDS PYVVVNMRIM 150
TRMGKQVLDV LGNGEFVPCL HSVGMPLAEG QKDVAWPCNK EKYIVHFPEE 200
RAIWSFGSGY GGNALLGKKC LALRIASVQA RDEGWLAEHM LILGVESPTG 250
EKSYVGAAFP SACGKTNFAM LIPPKPFQDK GWKVTTIGDD IAWIKPGADG 300
QVYAINPEYG YFGVAPGTNY KTNPNAMISC EKNSIFTNVA LTEDGDVWWE 350
GMDGEVPAKL TDWQGNAWTP DCGRPAAHPN ARFTAPASQC PCIDPEWENP 400
KGVPMSAFIF GGRRKDTVPL VYQAFNWNYG VYLASTLGSE TTAAAVGATG 450
NVRRDPFAML PFCGYHMADY FAHWLQFGRS IARPPRIFSV NWFRKDANGK 500
FIWPGYGENM RVLKWIAERV QGKTGSVECP LGWMPRYEDM DWEGIEMSRE 550
KFNELMSVDR DVWQNEVISH EELFVKMYDK LPKEFLHIRE LILSSLWRSP 600
EHWEQIGEVH PEGWNE 616
Length:616
Mass (Da):69,354
Last modified:July 22, 2008 - v1
Checksum:i63C63D9F8456221F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD97165.1.
RefSeqiWP_012471485.1. NC_010814.1.
YP_001953685.1. NC_010814.1.

Genome annotation databases

EnsemblBacteriaiACD97165; ACD97165; Glov_3462.
GeneIDi6368947.
KEGGiglo:Glov_3462.
PATRICi21998591. VBIGeoLov31523_3384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD97165.1 .
RefSeqi WP_012471485.1. NC_010814.1.
YP_001953685.1. NC_010814.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398767.Glov_3462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD97165 ; ACD97165 ; Glov_3462 .
GeneIDi 6368947.
KEGGi glo:Glov_3462.
PATRICi 21998591. VBIGeoLov31523_3384.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci GLOV398767:GH32-3514-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Entry informationi

Entry nameiB3E262_GEOLS
AccessioniPrimary (citable) accession number: B3E262
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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