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B3E262

- B3E262_GEOLS

UniProt

B3E262 - B3E262_GEOLS

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721SubstrateUniRule annotation
    Binding sitei212 – 2121Substrate; via amide nitrogenUniRule annotation
    Metal bindingi219 – 2191ManganeseUniRule annotation
    Binding sitei219 – 2191SubstrateUniRule annotation
    Metal bindingi239 – 2391Manganese; via tele nitrogenUniRule annotation
    Binding sitei261 – 2611SubstrateUniRule annotation
    Active sitei263 – 2631UniRule annotation
    Metal bindingi290 – 2901ManganeseUniRule annotation
    Binding sitei382 – 3821GTPUniRule annotation
    Binding sitei413 – 4131GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi262 – 2676GTPUniRule annotation
    Nucleotide bindingi506 – 5094GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. kinase activity Source: UniProtKB-KW
    3. manganese ion binding Source: UniProtKB-HAMAP
    4. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, KinaseImported, Lyase, Transferase

    Keywords - Biological processi

    GluconeogenesisUniRule annotation

    Keywords - Ligandi

    GTP-bindingUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

    Enzyme and pathway databases

    BioCyciGLOV398767:GH32-3514-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:Glov_3462Imported
    OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)Imported
    Taxonomic identifieri398767 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002420: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi398767.Glov_3462.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni380 – 3823Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3E262-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYEVKNEQL KAWVAEVEAM CEPANIHWCD GSQEEYDRLC GQMVESGTFR    50
    KLNPEKRPNS YLAFSDPIDV ARVEDRTFIC SLNKQDAGPT NNWVAPKEMK 100
    ETLKGLFKGC MKGRTMYVIP FSMGPLGSNI AKIGVEITDS PYVVVNMRIM 150
    TRMGKQVLDV LGNGEFVPCL HSVGMPLAEG QKDVAWPCNK EKYIVHFPEE 200
    RAIWSFGSGY GGNALLGKKC LALRIASVQA RDEGWLAEHM LILGVESPTG 250
    EKSYVGAAFP SACGKTNFAM LIPPKPFQDK GWKVTTIGDD IAWIKPGADG 300
    QVYAINPEYG YFGVAPGTNY KTNPNAMISC EKNSIFTNVA LTEDGDVWWE 350
    GMDGEVPAKL TDWQGNAWTP DCGRPAAHPN ARFTAPASQC PCIDPEWENP 400
    KGVPMSAFIF GGRRKDTVPL VYQAFNWNYG VYLASTLGSE TTAAAVGATG 450
    NVRRDPFAML PFCGYHMADY FAHWLQFGRS IARPPRIFSV NWFRKDANGK 500
    FIWPGYGENM RVLKWIAERV QGKTGSVECP LGWMPRYEDM DWEGIEMSRE 550
    KFNELMSVDR DVWQNEVISH EELFVKMYDK LPKEFLHIRE LILSSLWRSP 600
    EHWEQIGEVH PEGWNE 616
    Length:616
    Mass (Da):69,354
    Last modified:July 22, 2008 - v1
    Checksum:i63C63D9F8456221F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001089 Genomic DNA. Translation: ACD97165.1.
    RefSeqiWP_012471485.1. NC_010814.1.
    YP_001953685.1. NC_010814.1.

    Genome annotation databases

    EnsemblBacteriaiACD97165; ACD97165; Glov_3462.
    GeneIDi6368947.
    KEGGiglo:Glov_3462.
    PATRICi21998591. VBIGeoLov31523_3384.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001089 Genomic DNA. Translation: ACD97165.1 .
    RefSeqi WP_012471485.1. NC_010814.1.
    YP_001953685.1. NC_010814.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398767.Glov_3462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD97165 ; ACD97165 ; Glov_3462 .
    GeneIDi 6368947.
    KEGGi glo:Glov_3462.
    PATRICi 21998591. VBIGeoLov31523_3384.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci GLOV398767:GH32-3514-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1151 / DSM 17278 / SZImported.

    Entry informationi

    Entry nameiB3E262_GEOLS
    AccessioniPrimary (citable) accession number: B3E262
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3