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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use ions such as Zn2+, Mg2+ or Co2+.UniRule annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei142SubstrateUniRule annotation1
Binding sitei143SubstrateUniRule annotation1
Metal bindingi172Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi217Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi274Divalent metal cation; shared with dimeric partnerUniRule annotation1
Binding sitei282SubstrateUniRule annotation1
Binding sitei291SubstrateUniRule annotation1
Binding sitei300SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridoxine biosynthesis
LigandCobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciGLOV398767:G1GC4-3451-MONOMER
UniPathwayiUPA00244; UER00312

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:Glov_3452
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001282501 – 3364-hydroxythreonine-4-phosphate dehydrogenaseAdd BLAST336

Proteomic databases

PRIDEiB3E252

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi398767.Glov_3452

Structurei

3D structure databases

ProteinModelPortaliB3E252
SMRiB3E252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEZ Bacteria
COG1995 LUCA
HOGENOMiHOG000221593
KOiK00097
OMAiGHLYPGH
OrthoDBiPOG091H03XD

Family and domain databases

HAMAPiMF_00536 PdxA, 1 hit
InterProiView protein in InterPro
IPR037510 PdxA
IPR005255 PdxA_fam
PANTHERiPTHR30004 PTHR30004, 1 hit
PfamiView protein in Pfam
PF04166 PdxA, 1 hit
TIGRFAMsiTIGR00557 pdxA, 1 hit

Sequencei

Sequence statusi: Complete.

B3E252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPKPQIAI TMGDPCGVGP EIIVAALSDP AIRSACKPLV LGDRRAMQRA
60 70 80 90 100
LTVCNSPLEL ITVSSPAEAA DLPDSVIPLL ELSSLANTDI DYGKPSELSG
110 120 130 140 150
DAVYRYIRRA AELCLTGEVA AMATAPISKE AMHRAGHHYP GHTELLAELC
160 170 180 190 200
RCDEFVMMLA GDVLRVALVT IHEALAHVPA LISTEQVLKT IRVTANGVAP
210 220 230 240 250
LCGNRSPRIA VLALNPHCGE GGMFGSEEAD AIIPAITAAQ SEGLDVAGPF
260 270 280 290 300
SADTFFHFAV QEPAPYDAVV AMYHDQGLIP LKMRHFDDGI NITLGLPIIR
310 320 330
TSVDHGTAYN LAGTGTASAT SMKASIRIAA KLAATR
Length:336
Mass (Da):35,378
Last modified:July 22, 2008 - v1
Checksum:iB31782D52694E307
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA Translation: ACD97155.1
RefSeqiWP_012471475.1, NC_010814.1

Genome annotation databases

EnsemblBacteriaiACD97155; ACD97155; Glov_3452
KEGGiglo:Glov_3452

Similar proteinsi

Entry informationi

Entry nameiPDXA_GEOLS
AccessioniPrimary (citable) accession number: B3E252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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