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B3E1T2

- PYRF_GEOLS

UniProt

B3E1T2 - PYRF_GEOLS

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151SubstrateUniRule annotation
Binding sitei37 – 371SubstrateUniRule annotation
Active sitei66 – 661Proton donorUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei187 – 1871SubstrateUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Binding sitei216 – 2161Substrate; via amide nitrogenUniRule annotation
Binding sitei217 – 2171SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciGLOV398767:GH32-1892-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Glov_1866
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002420: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Orotidine 5'-phosphate decarboxylasePRO_1000138531Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi398767.Glov_1866.

Structurei

3D structure databases

ProteinModelPortaliB3E1T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 7310Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3E1T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRDEAKNKI IFALDVDNLK DIDCWAEKLS RKVGMFKVGK ELFTSAGPAA
60 70 80 90 100
VEAVKKHAGE VFLDLKYHDI PNTVAQAMLA AGRLGVKLAN LHALGGPEMM
110 120 130 140 150
EKASQAVRKE FSENERPRLL AVTILTSSTQ DTLKAVGIEH PVEEMVVRLA
160 170 180 190 200
KLAKESGMDG VVASPLEIEA IRAACGPDFL IVTPGVRPSF AAVDDQKRIM
210 220 230 240
TPAEAVKAGA DYLVIGRPIA KAADPIQAAE LIVDEIVAGV Q
Length:241
Mass (Da):25,821
Last modified:July 22, 2008 - v1
Checksum:i9940794C8B7C3DDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD95582.1.
RefSeqiYP_001952102.1. NC_010814.1.

Genome annotation databases

EnsemblBacteriaiACD95582; ACD95582; Glov_1866.
GeneIDi6368885.
KEGGiglo:Glov_1866.
PATRICi21995407. VBIGeoLov31523_1809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001089 Genomic DNA. Translation: ACD95582.1 .
RefSeqi YP_001952102.1. NC_010814.1.

3D structure databases

ProteinModelPortali B3E1T2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398767.Glov_1866.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD95582 ; ACD95582 ; Glov_1866 .
GeneIDi 6368885.
KEGGi glo:Glov_1866.
PATRICi 21995407. VBIGeoLov31523_1809.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci GLOV398767:GH32-1892-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1151 / DSM 17278 / SZ.

Entry informationi

Entry nameiPYRF_GEOLS
AccessioniPrimary (citable) accession number: B3E1T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3