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Protein

Catalase-peroxidase

Gene

katG

Organism
Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei90Transition state stabilizerUniRule annotation1
Active sitei94Proton acceptorUniRule annotation1
Metal bindingi257Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Minf_2274
OrganismiMethylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4))
Taxonomic identifieri481448 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaunclassified VerrucomicrobiaMethylacidiphilalesMethylacidiphilaceaeMethylacidiphilum
Proteomesi
  • UP000009149 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548311 – 726Catalase-peroxidaseAdd BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki93 ↔ 216Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-242)UniRule annotation
Cross-linki216 ↔ 242Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-93)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB3E099.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi481448.Minf_2274.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3E099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEGSCPFH HTAAIGGLKT NEEWWPNRLN LKILRQNSPL SNPMGAGFNY
60 70 80 90 100
AKEFCSLDLS ALKEDLRRLM TDSQQWWPAD FGHYGPLFIR MAWHSAGTYR
110 120 130 140 150
VHDGRGGAGS GQQRFAPLNS WPDNVLLDKA RRLLWPIKQK YGRKISWADL
160 170 180 190 200
IILAGNVALE SMGLKTFGFG GGRVDSWEPD ESVYWGVEQK WLEDKRYSGK
210 220 230 240 250
RDLEQPLAAV QMGLIYVNPE GPNGNPDPVA AAVDIRETFT RMGMNDAETV
260 270 280 290 300
ALIAGGHTFG KAHGAGPASF VGPEPEAAGI AEQGLGWRSS YRSGKGADAI
310 320 330 340 350
GSGLEVIWTR TPTRWNNDYF QFLFEYEWEP TKSPAGAWQW VAKDAPEIVP
360 370 380 390 400
DPFDPAKKRK PTMLTTDLSL RFDPVYEKIA RAYYEQPDLF ADAFARAWFK
410 420 430 440 450
LTHRDMGPRS RYLGPEVPKE DLLWQDPIPP VDHPLIETDD MNSLKAKILE
460 470 480 490 500
SGLTVRELVF TAWSSASTFR GSDKRGGANG ARIRLSPQKD WPANEPTQLA
510 520 530 540 550
RVLAVLEQIQ KEFNARSPKK VSMADLIVLG GCAGVEQAAR NGGRSVVVPF
560 570 580 590 600
IPGRSDALEE QTDVESFAFL EPWADGFRNF YKKGCSVPQE ALLVDKAQLL
610 620 630 640 650
TLTAPEMTVL VGGMRVLDAN VGRSRHGVFT DRPGALTNDF FVNLLDMDTE
660 670 680 690 700
WKPVDEREEL FEGRDRKTGT LLWTATRVDL IFGSNSELRA ISEVYGAADA
710 720
QDKFVKDFIS AWNKVMNLDR FDLAPA
Length:726
Mass (Da):80,954
Last modified:July 22, 2008 - v1
Checksum:i5DDBE77260C22A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000975 Genomic DNA. Translation: ACD84328.1.
RefSeqiWP_012464608.1. NC_010794.1.

Genome annotation databases

EnsemblBacteriaiACD84328; ACD84328; Minf_2274.
KEGGimin:Minf_2274.
PATRICi22493797. VBIMetInf111569_2366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000975 Genomic DNA. Translation: ACD84328.1.
RefSeqiWP_012464608.1. NC_010794.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi481448.Minf_2274.

Proteomic databases

PRIDEiB3E099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD84328; ACD84328; Minf_2274.
KEGGimin:Minf_2274.
PATRICi22493797. VBIMetInf111569_2366.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_METI4
AccessioniPrimary (citable) accession number: B3E099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.