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Protein

dCTP deaminase

Gene

dcd

Organism
Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138Proton donor/acceptorUniRule annotation1
Binding sitei157dCTPUniRule annotation1
Binding sitei171dCTPUniRule annotation1
Binding sitei181dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 117dCTP bindingUniRule annotation6
Nucleotide bindingi136 – 138dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciMINF481448:G1GBH-77-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Minf_0086
OrganismiMethylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4))
Taxonomic identifieri481448 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaMethylacidiphilaeMethylacidiphilalesMethylacidiphilaceaeMethylacidiphilum
Proteomesi
  • UP000009149 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000964371 – 189dCTP deaminaseAdd BLAST189

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi481448.Minf_0086

Structurei

3D structure databases

ProteinModelPortaliB3DX06
SMRiB3DX06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228600
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

B3DX06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVHSDDWIR QMVKKHRMIE PFEESQVRKK VDGSQVISFG LSSYGYDLRV
60 70 80 90 100
SREFKIFTNV FNSVVDPKAF DPRSFVEMES DCCIIPPNSF ALARSVEYFR
110 120 130 140 150
IPRDVITICL GKSTYARCGI IVNVTPFEPE WEGYATLEIS NTTPLPAKVY
160 170 180
AEEGLAQVIF IQASEPCSIS YAERNGKYMY QKGVTVPRL
Length:189
Mass (Da):21,514
Last modified:July 22, 2008 - v1
Checksum:i64C9FC2CFE3C744E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000975 Genomic DNA Translation: ACD82146.1
RefSeqiWP_012462428.1, NC_010794.1

Genome annotation databases

EnsemblBacteriaiACD82146; ACD82146; Minf_0086
KEGGimin:Minf_0086

Similar proteinsi

Entry informationi

Entry nameiDCD_METI4
AccessioniPrimary (citable) accession number: B3DX06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health