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B3DVB8 (B3DVB8_METI4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ACD83271.1
Ordered Locus Names:Minf_1216
OrganismMethylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4)) [Complete proteome] [HAMAP]
Taxonomic identifier481448 [NCBI]
Taxonomic lineageBacteria › Verrucomicrobia › unclassified Verrucomicrobia › Methylacidiphilales › Methylacidiphilaceae › Methylacidiphilum

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region267 – 2715ACP-binding By similarity HAMAP MF_01815

Sites

Active site1261 By similarity HAMAP MF_01815
Active site2661 By similarity HAMAP MF_01815
Active site2961 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B3DVB8 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 8B41073BA9446FC8

FASTA34337,392
        10         20         30         40         50         60 
MNLSNAKNPP LYRLPEVVIQ GSGIYLPSKV LTNHDLEKMV NTTDEWITER TGIKERRIAG 

        70         80         90        100        110        120 
EKETPSEMGA MAAMMALQNA GLTAEDLDMI IVATTTPDTI FPSTACYIQH KIGARTIPSF 

       130        140        150        160        170        180 
DIQAACSGFI YGFILASHFI ACRSARHILL IGAEKLSAIV NWEDRNTCVL FGDGAGALII 

       190        200        210        220        230        240 
SPGENSPDQL SFDIGADGSQ WQILYIPAGG SKLPLTAQNI NHKLHFLHMV GKKVFKLAID 

       250        260        270        280        290        300 
SMEQSLTRCI EKAGISAEHI ACIIPHQANL RIIEALSERL GIPGEKFFVN MEKYGNTSSA 

       310        320        330        340 
CIPIAFHEAV ASQRIKEGDI VLFVSFGAGI TWGSVLFRYK AKA

« Hide

References

[1]"Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum Verrucomicrobia."
Hou S., Makarova K.S., Saw J.H., Senin P., Ly B.V., Zhou Z., Ren Y., Wang J., Galperin M.Y., Omelchenko M.V., Wolf Y.I., Yutin N., Koonin E.V., Stott M.B., Mountain B.W., Crowe M.A., Smirnova A.V., Dunfield P.F. expand/collapse author list , Feng L., Wang L., Alam M.
Biol. Direct 3:26-26(2008) [PubMed: 18593465] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate V4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000975 Genomic DNA. Translation: ACD83271.1.
RefSeqYP_001939869.1. NC_010794.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB3DVB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6352151.
GenomeReviewsGene locus Minf_1216 in contig CP000975_GR.
KEGGmin:Minf_1216.
PATRIC22491575. VBIMetInf111569_1274.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMADVNTACS.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB3DVB8_METI4
AccessionPrimary (citable) accession number: B3DVB8
Entry history
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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