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Protein

Peptide deformylase

Gene

def

Organism
Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi106IronUniRule annotation1
Metal bindingi148IronUniRule annotation1
Active sitei149UniRule annotation1
Metal bindingi152IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMINF481448:G1GBH-824-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:Minf_0917
OrganismiMethylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4))
Taxonomic identifieri481448 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaMethylacidiphilaeMethylacidiphilalesMethylacidiphilaceaeMethylacidiphilum
Proteomesi
  • UP000009149 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000973231 – 190Peptide deformylaseAdd BLAST190

Interactioni

Protein-protein interaction databases

STRINGi481448.Minf_0917

Structurei

3D structure databases

SMRiB3DUG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243509
KOiK01462
OMAiVCIQHEI
OrthoDBiPOG091H02B0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.101 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

B3DUG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILKLVLYDN PILRKKGMPI DSFDDRLKRL VQDMLETMAY YKGVGLAAQQ
60 70 80 90 100
VGLNLQLAVI DVSGSKLSSS LLIGGKPAMV EEHMPLFLIN PTLSYTQSKE
110 120 130 140 150
ISNEGCLSFP GLRIDVPRSK RVKVKTFDLE GRPWYFEAGG FLSVAIQHEF
160 170 180 190
DHLQGKLFID YLSAEQKKAI KEELEKIKRG EAILSVKETD
Length:190
Mass (Da):21,388
Last modified:July 22, 2008 - v1
Checksum:i486AC49046D19A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000975 Genomic DNA Translation: ACD82972.1
RefSeqiWP_012463254.1, NC_010794.1

Genome annotation databases

EnsemblBacteriaiACD82972; ACD82972; Minf_0917
KEGGimin:Minf_0917

Similar proteinsi

Entry informationi

Entry nameiDEF_METI4
AccessioniPrimary (citable) accession number: B3DUG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: February 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome