Reviewed, UniProtKB/Swiss-Prot B3DTK7 (NTPA_BIFLD)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BLD_1030

Organism

Bifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]

Taxonomic identifier

205913 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000145480

Sequences

	Sequence		Length	Mass (Da)
	B3DTK7-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 9AC7D82C052CE0E3	FASTA	252	26,448
	10 20 30 40 50 60 MQIVVATHNE GKLVEIRRIL EEDLGADAEN IELVSAGSLH LPDPVETGVT FQENALLKAR 70 80 90 100 110 120 AVAIRTGLPA VADDSGLIVD VMGNAPGILS ARWAGAHGHD KANNALLLAQ IEDIPDDKRT 130 140 150 160 170 180 ARFRCAAALV VPDTETGADV TGGVAADGIT VHTTAADGSP APVHARYAIK SETVELGDMP 190 200 210 220 230 240 GRIIREARGE HGFGYDPLFV PDDQPAGRVS TEPDHEGEPL TSAEMTPAEK NAISHRGKAL 250 KALVPAIEAL LH

References

[1]

"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth." Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J. BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000605 Genomic DNA. Translation: ACD98476.1.
RefSeq	YP_001954974.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6363318.
GenomeReviews	Gene locus BLD_1030 in contig CP000605_GR.
KEGG	blj:BLD_1030.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NACLKAS.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_BIFLD

Accession

Primary (citable) accession number: B3DTK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)