Reviewed, UniProtKB/Swiss-Prot B3DTJ5 (ARAA_BIFLD)

Names and originHide

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	BLD_1018

Organism

Bifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]

Taxonomic identifier

205913 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributesHide

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

OntologiesHide

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	L-arabinose isomerase HAMAP MF_00519		PRO_1000127597
Sites
	Metal binding	308	1	Manganese By similarity
	Metal binding	335	1	Manganese By similarity
	Metal binding	352	1	Manganese By similarity
	Metal binding	453	1	Manganese By similarity

SequencesHide

	Sequence		Length	Mass (Da)
	B3DTJ5-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 7665BFB00AD37E4C	FASTA	505	55,868
	10 20 30 40 50 60 MVMENPFEGK EIWFGVGSQD LYGEEALRQV AIHSAEMVDY LNNTGKIPAK IVLKPTLKSS 70 80 90 100 110 120 DGVKEFMVEA SANPNVIGVI TWCHTFSPAK MWIRGLEVLT KPLLQLATQH HKEIPWETID 130 140 150 160 170 180 MDFMNLNQAA HGDREFGYIV SRLGIKRKVV VGHYTDPEVA EKLGTWARAC AGWDASNNMK 190 200 210 220 230 240 VMRWGDNMRN VAVTEGDKTE AERVFGASIN TWAVNELVAA YDAVKDDQVK EIIEDYKAKY 250 260 270 280 290 300 DVDPALLDAK YDSLFIAAKE EAAMVNMMRA NGCTAGVDNF EDLGALPQLP GVGPQRFPSE 310 320 330 340 350 360 YGWGFSAEGD WKTAVLVRIG AVMGYGLEGG ASLMEDYSYN FTEGDELDMG SHMLEVSPSI 370 380 390 400 410 420 GTIAKPKLEI HPLGIGGKAD PVRLVFSGKP AKDAVVVSMS DVRERFRLLM DVVDVVEPQG 430 440 450 460 470 480 SLKELPCARA VWEPKPSLKT AVECWITAGG SHHTCMTTSV GREAWEDFAR IAGVELAVID 490 500 ENTTARQFEK ELELSEMYHR LNNQH

ReferencesHide

[1]

"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth." Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J. BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	CP000605 Genomic DNA. Translation: ACD98464.1.
RefSeq	YP_001954962.1.
3D structure databases
SMR	B3DTJ5. Positions 5-501.
ModBase	Search...
Genome annotation databases
GeneID	6362657.
GenomeReviews	Gene locus BLD_1018 in contig CP000605_GR.
KEGG	blj:BLD_1018.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297198.
OMA	EVCPTIA.
ProtClustDB	PRK02929.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR003762. Lara_isomerase. [Graphical view]
Pfam	PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry informationHide

Entry name

ARAA_BIFLD

Accession

Primary (citable) accession number: B3DTJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	April 20, 2010
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)