Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B3DT87

- LUXS_BIFLD

UniProt

B3DT87 - LUXS_BIFLD

Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Bifidobacterium longum (strain DJO10A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

    Catalytic activityi

    S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

    Cofactori

    Binds 1 iron ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611IronUniRule annotation
    Metal bindingi65 – 651IronUniRule annotation
    Metal bindingi131 – 1311IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. quorum sensing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Autoinducer synthesis, Quorum sensing

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBLON205913:GJB4-940-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
    Alternative name(s):
    AI-2 synthesis proteinUniRule annotation
    Autoinducer-2 production protein LuxSUniRule annotation
    Gene namesi
    Name:luxSUniRule annotation
    Ordered Locus Names:BLD_0910
    OrganismiBifidobacterium longum (strain DJO10A)
    Taxonomic identifieri205913 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000002419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164S-ribosylhomocysteine lyasePRO_1000093302Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi205913.BLD_0910.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LuxS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1854.
    HOGENOMiHOG000040372.
    KOiK07173.
    OMAiRDHLNSD.
    OrthoDBiEOG68WRBM.

    Family and domain databases

    Gene3Di3.30.1360.80. 1 hit.
    HAMAPiMF_00091. LuxS.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view]
    PfamiPF02664. LuxS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006160. AI2. 1 hit.
    PRINTSiPR01487. LUXSPROTEIN.
    ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63411. SSF63411. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3DT87-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEETAEKPV VESFQLDHTK VKAPYVRYID TETGPHGDVI SNYDLRLTQP    50
    NKQAIPTGGL HTIEHTIAVL LRERIPGYID CSPFGCRTGF HLLTWGTHPT 100
    EEVAKALKES LEFIAYKATW DDVPATTEKS CGNYRDHSLF TAKEWAKQIL 150
    EEGISSDPFE RKVV 164
    Length:164
    Mass (Da):18,489
    Last modified:July 22, 2008 - v1
    Checksum:i3CB74EFD19788C4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000605 Genomic DNA. Translation: ACD98356.1.
    RefSeqiYP_001954854.1. NC_010816.1.

    Genome annotation databases

    EnsemblBacteriaiACD98356; ACD98356; BLD_0910.
    GeneIDi6364297.
    KEGGiblj:BLD_0910.
    PATRICi21114770. VBIBifLon134794_0923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000605 Genomic DNA. Translation: ACD98356.1 .
    RefSeqi YP_001954854.1. NC_010816.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205913.BLD_0910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD98356 ; ACD98356 ; BLD_0910 .
    GeneIDi 6364297.
    KEGGi blj:BLD_0910.
    PATRICi 21114770. VBIBifLon134794_0923.

    Phylogenomic databases

    eggNOGi COG1854.
    HOGENOMi HOG000040372.
    KOi K07173.
    OMAi RDHLNSD.
    OrthoDBi EOG68WRBM.

    Enzyme and pathway databases

    BioCyci BLON205913:GJB4-940-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.80. 1 hit.
    HAMAPi MF_00091. LuxS.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view ]
    Pfami PF02664. LuxS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006160. AI2. 1 hit.
    PRINTSi PR01487. LUXSPROTEIN.
    ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63411. SSF63411. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
      Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
      BMC Genomics 9:247-247(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DJO10A.

    Entry informationi

    Entry nameiLUXS_BIFLD
    AccessioniPrimary (citable) accession number: B3DT87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3