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Protein

Alanine racemase

Gene

alr

Organism
Bifidobacterium longum (strain DJO10A)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei163 – 1631SubstrateUniRule annotation
Active sitei301 – 3011Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei365 – 3651Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBLON205913:GJB4-936-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BLD_0906Imported
OrganismiBifidobacterium longum (strain DJO10A)Imported
Taxonomic identifieri205913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002419: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi205913.BLD_0906.

Structurei

3D structure databases

ProteinModelPortaliB3DT83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DT83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAPEIAFS SEQGKANYAA ARRQYPAQAI VDLKTMRDNM AHLVSVVGGP
60 70 80 90 100
ASGTAVMGVV KADAYGHGLL PAALAALAGG ATWLGTAQSH EALLLRKLGI
110 120 130 140 150
GPDRCHILTW VYNGTEVPFD ELIAADIDVS VGSLPGIDAV AAAARKLGKP
160 170 180 190 200
ARVHVKVDSG FGRNGFTPAG FDAALAKLVP LAKEGVLHIV GQWSHLAVAD
210 220 230 240 250
SPDVSEFVSS TDRQIETFKD FTRRMEQAGI PPEIRHLANT AATLDRPEIH
260 270 280 290 300
FELTRPGIGL YGYEPDPAMG TPRDWHLTPA MRLQAQLGTV KDVEAGHGIS
310 320 330 340 350
YGRTYLTLDN TSTAIVPLGY ADGIHRSASG FDMEGAKHVE KPGGPVRIMT
360 370 380 390 400
TEGPKIYRVC GRVCMDQFIV DLHGSAAELG VHEGDTVELF GPGRGEDYVE
410 420 430 440 450
PTADDWARAA DTISYEIFTC LRNRIPRLYE HAAEVLPAAD LAKLDPATLL
Length:450
Mass (Da):48,055
Last modified:July 22, 2008 - v1
Checksum:i5C48192B290E7B17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA. Translation: ACD98352.1.
RefSeqiYP_001954850.1. NC_010816.1.

Genome annotation databases

EnsemblBacteriaiACD98352; ACD98352; BLD_0906.
GeneIDi6363126.
KEGGiblj:BLD_0906.
PATRICi21114760. VBIBifLon134794_0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA. Translation: ACD98352.1.
RefSeqiYP_001954850.1. NC_010816.1.

3D structure databases

ProteinModelPortaliB3DT83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205913.BLD_0906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD98352; ACD98352; BLD_0906.
GeneIDi6363126.
KEGGiblj:BLD_0906.
PATRICi21114760. VBIBifLon134794_0918.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBLON205913:GJB4-936-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of two cryptic plasmids from Bifidobacterium longum DJO10A and construction of a shuttle cloning vector."
    Lee J.H., O'Sullivan D.J.
    Appl. Environ. Microbiol. 72:527-535(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJO10AImported.
  2. "Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
    Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
    BMC Genomics 9:247-247(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJO10AImported.

Entry informationi

Entry nameiB3DT83_BIFLD
AccessioniPrimary (citable) accession number: B3DT83
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: March 4, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.