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Protein

Alanine racemase

Gene

alr

Organism
Bifidobacterium longum (strain DJO10A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Active sitei301Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei365Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BLD_0906Imported
OrganismiBifidobacterium longum (strain DJO10A)Imported
Taxonomic identifieri205913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000002419 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliB3DT83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 430Ala_racemase_CInterPro annotationAdd BLAST151

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWEILCGF.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

B3DT83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAPEIAFS SEQGKANYAA ARRQYPAQAI VDLKTMRDNM AHLVSVVGGP
60 70 80 90 100
ASGTAVMGVV KADAYGHGLL PAALAALAGG ATWLGTAQSH EALLLRKLGI
110 120 130 140 150
GPDRCHILTW VYNGTEVPFD ELIAADIDVS VGSLPGIDAV AAAARKLGKP
160 170 180 190 200
ARVHVKVDSG FGRNGFTPAG FDAALAKLVP LAKEGVLHIV GQWSHLAVAD
210 220 230 240 250
SPDVSEFVSS TDRQIETFKD FTRRMEQAGI PPEIRHLANT AATLDRPEIH
260 270 280 290 300
FELTRPGIGL YGYEPDPAMG TPRDWHLTPA MRLQAQLGTV KDVEAGHGIS
310 320 330 340 350
YGRTYLTLDN TSTAIVPLGY ADGIHRSASG FDMEGAKHVE KPGGPVRIMT
360 370 380 390 400
TEGPKIYRVC GRVCMDQFIV DLHGSAAELG VHEGDTVELF GPGRGEDYVE
410 420 430 440 450
PTADDWARAA DTISYEIFTC LRNRIPRLYE HAAEVLPAAD LAKLDPATLL
Length:450
Mass (Da):48,055
Last modified:July 22, 2008 - v1
Checksum:i5C48192B290E7B17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA. Translation: ACD98352.1.

Genome annotation databases

EnsemblBacteriaiACD98352; ACD98352; BLD_0906.
KEGGiblj:BLD_0906.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB3DT83_BIFLD
AccessioniPrimary (citable) accession number: B3DT83
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported