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B3DT56

- PUR5_BIFLD

UniProt

B3DT56 - PUR5_BIFLD

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bifidobacterium longum (strain DJO10A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON205913:GJB4-908-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:BLD_0879
OrganismiBifidobacterium longum (strain DJO10A)
Taxonomic identifieri205913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002419: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000192998Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205913.BLD_0879.

Structurei

3D structure databases

ProteinModelPortaliB3DT56.
SMRiB3DT56. Positions 13-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B3DT56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKAYENAGV SVEAGYEVVK RIKSHVARTN RPGVVGGIGG FGGLFDLASL
60 70 80 90 100
GYKEPVLISG TDGVGTKLMV AKLANKHDTI GIDCVAMCVN DIAAQGAEPL
110 120 130 140 150
FFLDYIACGK NDPALLEQVV AGVADGCVQA GSALVGGETA EMPGMYDEDE
160 170 180 190 200
YDLAGFSVGV AEKSAIVDGS TIAEGDVLIG LPSTGVHSNG FSLVRKALFE
210 220 230 240 250
QAGYTVDTEL DELGGEKLGD VLLTPTKIYV KALSPLFKAG VVKGVAHITG
260 270 280 290 300
GGFIENIPRM IPDGLAAEIE LGTWPVLPIF DVLEKAGNID HKEMYNIFNM
310 320 330 340
GIGMVLAIDP ARKDEALKLL ADNNEPAYVL GSITADTTGT QIVLK
Length:345
Mass (Da):36,002
Last modified:July 22, 2008 - v1
Checksum:i4A48C60D24891797
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000605 Genomic DNA. Translation: ACD98325.1.
RefSeqiYP_001954823.1. NC_010816.1.

Genome annotation databases

EnsemblBacteriaiACD98325; ACD98325; BLD_0879.
GeneIDi6362851.
KEGGiblj:BLD_0879.
PATRICi21114704. VBIBifLon134794_0891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000605 Genomic DNA. Translation: ACD98325.1 .
RefSeqi YP_001954823.1. NC_010816.1.

3D structure databases

ProteinModelPortali B3DT56.
SMRi B3DT56. Positions 13-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205913.BLD_0879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD98325 ; ACD98325 ; BLD_0879 .
GeneIDi 6362851.
KEGGi blj:BLD_0879.
PATRICi 21114704. VBIBifLon134794_0891.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci BLON205913:GJB4-908-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
    Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
    BMC Genomics 9:247-247(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJO10A.

Entry informationi

Entry nameiPUR5_BIFLD
AccessioniPrimary (citable) accession number: B3DT56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3