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B3DSY7

- ASSY_BIFLD

UniProt

B3DSY7 - ASSY_BIFLD

Protein

Argininosuccinate synthase

Gene

argG

Organism
Bifidobacterium longum (strain DJO10A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891CitrullineUniRule annotation
    Binding sitei119 – 1191ATP; via amide nitrogenUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei129 – 1291CitrullineUniRule annotation
    Binding sitei177 – 1771CitrullineUniRule annotation
    Binding sitei261 – 2611CitrullineUniRule annotation
    Binding sitei273 – 2731CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON205913:GJB4-838-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:BLD_0810
    OrganismiBifidobacterium longum (strain DJO10A)
    Taxonomic identifieri205913 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000002419: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Argininosuccinate synthasePRO_1000089023Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi205913.BLD_0810.

    Structurei

    3D structure databases

    ProteinModelPortaliB3DSY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3DSY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADNKRIVLA YSGGLDTSVA ISYLKERTGK DVVAVSLDVG QGGESLETIK    50
    QRALACGAVE SYVVDARDEF ANEYCMKALK ANAMYEGVYP LVSAISRPLI 100
    SKHLVRAAHQ FGADTISHGC TGKGNDQVRF EVSIASIDPT LKAISPIRDL 150
    SLTRDVEIAF AKEHKLPITQ TEKSPYSIDQ NVWGRAIETG FLEDPWNGPT 200
    KDCYSYTDDP AFPPVEDEVV IEFKEGVPVK IDGRDVTPLQ AIEEMNRRAG 250
    AQGVGRIDLI EDRLVGIKSR ELYEAPGAVA LITAHQELEN CCLEREQHRI 300
    KRDIDKRWGE LVYDAQWFSP ATQSLNAFIE DTQKYVSGEI RMVLHGGRAV 350
    VTGRRSDSSL YDYKLATYDS GDTFDQKSSN GFIDIYGLPS RVAAARDVKF 400
    GNGIEVPENT VE 412
    Length:412
    Mass (Da):45,507
    Last modified:July 22, 2008 - v1
    Checksum:i488BD98E71C6EB17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000605 Genomic DNA. Translation: ACD98256.1.
    RefSeqiYP_001954754.1. NC_010816.1.

    Genome annotation databases

    EnsemblBacteriaiACD98256; ACD98256; BLD_0810.
    GeneIDi6362924.
    KEGGiblj:BLD_0810.
    PATRICi21114564. VBIBifLon134794_0822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000605 Genomic DNA. Translation: ACD98256.1 .
    RefSeqi YP_001954754.1. NC_010816.1.

    3D structure databases

    ProteinModelPortali B3DSY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205913.BLD_0810.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD98256 ; ACD98256 ; BLD_0810 .
    GeneIDi 6362924.
    KEGGi blj:BLD_0810.
    PATRICi 21114564. VBIBifLon134794_0822.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BLON205913:GJB4-838-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
      Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
      BMC Genomics 9:247-247(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DJO10A.

    Entry informationi

    Entry nameiASSY_BIFLD
    AccessioniPrimary (citable) accession number: B3DSY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3