B3DSY6 (ARLY_BIFLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BLD_0809

Organism

Bifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]

Taxonomic identifier

205913 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089067

Sequences

	Sequence		Length	Mass (Da)
	B3DSY6 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 947BC541D5A7E78A	FASTA	490	53,392
	10 20 30 40 50 60 MTENNEHLAL WGGRFTSGPS PELARLSKST QFDWRLADDD IAGSRAHARA LGRAGLLTAD 70 80 90 100 110 120 ELQRMEDALD TLQRHVDDGS FAPIEDDEDE ATALERGLID IAGDELGGKL RAGRSRNDQI 130 140 150 160 170 180 ACLIRMWLRR HSRVIAGLLL DLVNALIEQS EKAGRTVMPG RTHMQHAQPV LLAHQLMAHA 190 200 210 220 230 240 WPLIRDVQRL IDWDKRINAS PYGSGALAGN TLGLDPEAVA RELGFSRVTD NSIDGTAARD 250 260 270 280 290 300 LVAEFAFVAA MTGVDISRLS EEIIIWNTQE FAFVKLDDGY STGSSIMPQK KNPDIAELAR 310 320 330 340 350 360 GKSGRLIGDL TGLLATLKGL PTAYARDLQE DKEAVFDQVD TLEVLLPAFT GMVRTMHFDG 370 380 390 400 410 420 DRLEEEAPTG FALATDIAEW LVKNGVPFRH AHELSGACVK LAEGRGQELW DLTDNDFIET 430 440 450 460 470 480 FAAFLPADKA PGVREVLSSH GSVDSRNGKG GTAYGRVREQ IADAKAEVEE LKLFPASTSD 490 GSAYKAPGTF

References

[1]

"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth." Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J. BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DJO10A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000605 Genomic DNA. Translation: ACD98255.1.
RefSeq	YP_001954753.1. NC_010816.1.
3D structure databases
ProteinModelPortal	B3DSY6.
ModBase	Search...
Protein-protein interaction databases
STRING	B3DSY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6362923.
GenomeReviews	Gene locus BLD_0809 in contig CP000605_GR.
KEGG	blj:BLD_0809.
PATRIC	21114562. VBIBifLon134794_0821.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	MPGRTHL.
ProtClustDB	PRK00855.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BIFLD

Accession

Primary (citable) accession number: B3DSY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program