Reviewed, UniProtKB/Swiss-Prot B3DSQ0 (AROA_BIFLD)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BLD_0723

Organism

Bifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]

Taxonomic identifier

205913 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000118779

Sequences

	Sequence		Length	Mass (Da)
	B3DSQ0-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 73021F77B9FA3291	FASTA	445	46,741
	10 20 30 40 50 60 MTERLTNLWP APLAAQPLNA TVTVPGSKSL SNRYLILAAL GSKPVTLIGL LRSRDTDLMM 70 80 90 100 110 120 GALEALGVRC DVDSATDTTV TVTPPVSGRF HGNVNVFCGL AGTVMRFVPG LALFADGPVN 130 140 150 160 170 180 FDGDEQAYAR PMKPVLDGLE QLGATVDYHG EVGRLPFTIT PPATLPAAQA QVSIDSSGSS 190 200 210 220 230 240 QFISGLLLIS SKLPGGLHLA HTGEKTPSLP HIRMTVADVT GAGGAVEADE SARTWTVEPR 250 260 270 280 290 300 AMQLSSKVTV EPDLSNAAPF LGAALIAGGT VRVPHWPETT TQPGGLLPGY LEQMGAEVSF 310 320 330 340 350 360 PTIGGVRYCE VTGDGTVRGL GTFDLTAAGE IAPSLAAILV FADKSTDMVG IGHLRGHETN 370 380 390 400 410 420 RLEALVNEIR RVGGAAEELP DGLRIEPVPA ETLHGAVMET YADHRMATFA AMLGLRIPDI 430 440 EVINVATTRK TLPDFVGMWS GMLRQ

References

[1]

"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth." Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J. BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000605 Genomic DNA. Translation: ACD98169.1.
RefSeq	YP_001954667.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6363214.
GenomeReviews	Gene locus BLD_0723 in contig CP000605_GR.
KEGG	blj:BLD_0723.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HRMATAG.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BIFLD

Accession

Primary (citable) accession number: B3DSQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)