B3DSD9 (AROC_BIFLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BLD_0612

Organism

Bifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]

Taxonomic identifier

205913 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Chorismate synthase HAMAP MF_00300		PRO_1000115329

Sequences

	Sequence		Length	Mass (Da)
	B3DSD9 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: E6EC2F9F3BBBC6D6	FASTA	395	42,363
	10 20 30 40 50 60 MLRWQTAGES HGEALVAMIE GLPAGVRIST DDIVSALARR RLGYGRGARM KFEQDKVRLL 70 80 90 100 110 120 TGVRHGLTLG SPVAIEIANT EWPKWTEVMS ADALDHDLPR EGRNAPLSRP RPGHADLTGM 130 140 150 160 170 180 RKYGFDDARP VLERSSARET ASRVALGEVA KQFLDQAFGI RTVAHVVALG GVQTNPDLPL 190 200 210 220 230 240 PTPDDLEALD ASPVRTLDKE AEARIIERIN EAKKASDTLG GVIEVLAYGV PAGIGTYVES 250 260 270 280 290 300 DRRLDAALAS AIMGIQAFKG VEIGDGFLEA SRPGSQAHDE IVVNADGRID RLSNRAGGIE 310 320 330 340 350 360 GGMSNGQVIR VRGAMKPIPS IPKALRTVDV LTGESAQAIN QRSDSTAVPA ASVVAEAMVR 370 380 390 LTLAKYALDK FGGDSVAETR RNLESYLASW PEHMR

References

[1]

"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth." Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J. BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DJO10A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000605 Genomic DNA. Translation: ACD98058.1.
RefSeq	YP_001954556.1. NC_010816.1.
3D structure databases
ProteinModelPortal	B3DSD9.
SMR	B3DSD9. Positions 1-389.
ModBase	Search...
Protein-protein interaction databases
STRING	B3DSD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6364338.
GenomeReviews	Gene locus BLD_0612 in contig CP000605_GR.
KEGG	blj:BLD_0612.
PATRIC	21114160. VBIBifLon134794_0627.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	MLRWLTA.
ProtClustDB	PRK05382.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. False negative. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BIFLD

Accession

Primary (citable) accession number: B3DSD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program