B3DS64 (B3DS64_BIFLD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Name:	metF EMBL ACD97983.1
Ordered Locus Names:	BLD_0537

Organism

Bifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]

Taxonomic identifier

205913 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3DS64 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 40CA848CEBD0F1BC	FASTA	284	31,477
	10 20 30 40 50 60 MHSPMFTLEV FPPKRNAPVG TIYDTLDGLE GLNPDFISVT YGHGTHSDRT ATARIAHTIS 70 80 90 100 110 120 KEYGIPAVAH LTALYSDKAK IDEALDMFEE AGVSAVLALR GDYIDGEQLV GEFNHASDLV 130 140 150 160 170 180 SYIRSVKPDF KVFGACYPEG HYQADSLDQD IENLKIKVDA GVTHLISQLF YDNEDFYRFL 190 200 210 220 230 240 DKARAAGITV PIEAGIMPVR GAKSVRRMAE RNASRIPDRL NTLLNKWGDD IQSLRAAGIL 250 260 270 280 YASEQIADLV AHDVDGVHLY SMNHPATTRR IWRNAEPLFR GTQG

References

[1]

"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth." Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J. BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000605 Genomic DNA. Translation: ACD97983.1.
RefSeq	YP_001954481.1. NC_010816.1.
3D structure databases
ProteinModelPortal	B3DS64.
ModBase	Search...
Protein-protein interaction databases
STRING	B3DS64.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6363351.
GenomeReviews	Gene locus BLD_0537 in contig CP000605_GR.
KEGG	blj:BLD_0537.
PATRIC	21114000. VBIBifLon134794_0549.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK638816.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B3DS64_BIFLD

Accession

Primary (citable) accession number: B3DS64

Entry history

Integrated into UniProtKB/TrEMBL:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)