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Protein

Glutamate-ammonia-ligase adenylyltransferase

Gene

glnE

Organism
Bifidobacterium longum (strain DJO10A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adenylation and deadenylation of glutamate--ammonia ligase.UniRule annotation

Catalytic activityi

ATP + [L-glutamate:ammonia ligase (ADP-forming)]-L-tyrosine = diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-O(4)-(5'-adenylyl)-L-tyrosine.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON205913:GJB4-554-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-ammonia-ligase adenylyltransferaseUniRule annotation (EC:2.7.7.42UniRule annotation)
Alternative name(s):
Glutamine-synthetase adenylyltransferase
Short name:
ATaseUniRule annotation
[Glutamate--ammonia-ligase] adenylyltransferaseUniRule annotation
Gene namesi
Name:glnEUniRule annotation
Ordered Locus Names:BLD_0535
OrganismiBifidobacterium longum (strain DJO10A)
Taxonomic identifieri205913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000002419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10761076Glutamate-ammonia-ligase adenylyltransferasePRO_1000133896Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB3DS62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 363205GlnE 1Add
BLAST
Regioni676 – 887212GlnE 2Add
BLAST

Sequence similaritiesi

Belongs to the GlnE family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000243040.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiEOG651SRZ.

Family and domain databases

HAMAPiMF_00802. GlnE.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DS62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSIFKPSS MDLIRAGLQD LDKARALFDQ LKADDIPDER CAELLSALAH
60 70 80 90 100
ACDPDMALSN FVDIVNAMQS SQRDLEHVIP DNDALKRLVT VLGVSDAMGK
110 120 130 140 150
FMRFKPQLVE AAAVDNCNSH LFNHAQRRAR LLKAVGADPD EPAMPVASKD
160 170 180 190 200
LAEAATALRS SYRNQLAAII AQDAVADDPT SIQPTISREL SDLADAALEG
210 220 230 240 250
ALAIARHETE GSEHVRFTII GMGKLGAQEL NYVSDVDLIY VVEPADKDVD
260 270 280 290 300
HQTLIRVGTK MGTMLQRVCQ SAIMGVAEQP LWQIDGGLRP EGKDGALVRV
310 320 330 340 350
LSSHKNYYEQ WAENWEFQAL LKARPVAGDP DLGQAYMDMT RPFVWSASKR
360 370 380 390 400
KNFVYDCQKM RKRVEDLIPA PLKDREIKLG RGGLRDVEFT VQMLQLVHGR
410 420 430 440 450
TDESLRTSNT LDSLQRLSEG GYVSRKQAVR MSQDYRFERV MEHRQQIWSL
460 470 480 490 500
KRTHLFPDLG RASVGGLEKK RDIDVDELNQ NQELRRLARA FGLHPEELVD
510 520 530 540 550
KYDDTRREVR HLHLDIYYRP MLPVNAQMEN DQIVLSVEAA QERFESIGFG
560 570 580 590 600
DPDAAIRHVQ ALTAGVGRAA KINRIILPAV LQWLGEGQNP DMGLLNWRKL
610 620 630 640 650
EENFGTESGY LGFLRDSTSA AQRLCHILSN SRFLGDALNK SVESISWLGD
660 670 680 690 700
DDNLQARTRE ALDVQTGSAL ERFGSNINEF ATSMRAMRRH EIERIGLSWM
710 720 730 740 750
SGVISDSDSL KAMTDVYDAI IDASLTWAVR HQIAEFGVET APAGITVIAM
760 770 780 790 800
GRYGGREVNF SSDADAILIY RPADDADDGQ ANAFAKKVVE DLRNILQGPT
810 820 830 840 850
TLEPKIELDL DLRPEGKNGP LVRSYASCEE YYESWASTWE RQALLRARYA
860 870 880 890 900
AGDAELARDF LINIADPLRY PTTELTEAEL QNIRKLKARM EAERLPRGVR
910 920 930 940 950
RERHLKLGKG GLSDVEWTVQ LMQLQHAGDI KDLRVNGTLE ALDVLEAKKL
960 970 980 990 1000
ISAIDAIQLR KAWTLCTAAR NGSYLWSGRA NQADILPDDI YSLGGIAVYL
1010 1020 1030 1040 1050
GYGAHRGQHF ENDLLAVMRK CRDVCQRLFY GKTEGEAAAA TTATASAATQ
1060 1070
QPQTAPRPRM HVIAPRLERN RRRAQR
Length:1,076
Mass (Da):120,299
Last modified:July 22, 2008 - v1
Checksum:i0B9FAD7BE26D36A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA. Translation: ACD97981.1.
RefSeqiWP_007052222.1. NC_010816.1.

Genome annotation databases

EnsemblBacteriaiACD97981; ACD97981; BLD_0535.
KEGGiblj:BLD_0535.
PATRICi21113996. VBIBifLon134794_0547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA. Translation: ACD97981.1.
RefSeqiWP_007052222.1. NC_010816.1.

3D structure databases

ProteinModelPortaliB3DS62.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD97981; ACD97981; BLD_0535.
KEGGiblj:BLD_0535.
PATRICi21113996. VBIBifLon134794_0547.

Phylogenomic databases

HOGENOMiHOG000243040.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiEOG651SRZ.

Enzyme and pathway databases

BioCyciBLON205913:GJB4-554-MONOMER.

Family and domain databases

HAMAPiMF_00802. GlnE.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
    Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
    BMC Genomics 9:247-247(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJO10A.

Entry informationi

Entry nameiGLNE_BIFLD
AccessioniPrimary (citable) accession number: B3DS62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: November 11, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.