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B3DRD0

- SYL_BIFLD

UniProt

B3DRD0 - SYL_BIFLD

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bifidobacterium longum (strain DJO10A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei763 – 7631ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON205913:GJB4-338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BLD_0328
OrganismiBifidobacterium longum (strain DJO10A)
Taxonomic identifieri205913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002419: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 987987Leucine--tRNA ligasePRO_1000091291Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205913.BLD_0328.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 8012"HIGH" regionAdd
BLAST
Motifi760 – 7645"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DRD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDNEKSTQT EEPNFRYNAA LAQDIENKWQ KIWDEQGTFW AANVNGDLKD
60 70 80 90 100
GKGRNAEGRT AYFAMDMFPY PSGKGLHVGH PLGYLASDVV SRYHRMKGEN
110 120 130 140 150
VLHAMGYDAF GLPAEQYAVQ TGQHPRVTTE ANIANMSRQL HRMGLSFDNR
160 170 180 190 200
RTFATIDPGY VRWTQWIFSR IYDSWYDEDA TNPSGSKGSA RPIAELVAKF
210 220 230 240 250
ESGEKAIPGH ESDGKQWSDL TDAEQQDILN DFRLAYISKS PVNWCPGLGT
260 270 280 290 300
VLANEEVTAE GKSERGNFPV FQRELRQWSM RITKYGHRLI ADLDGINWPE
310 320 330 340 350
KVKLMQRNWI GESHGASVHF TVATADGDKD MEIYTTRPDT LFGTTFAVVS
360 370 380 390 400
PEHHLLENVP AEWPADVPED WKGGYANPVE AVKAYRLAAE AKTAKDRVNE
410 420 430 440 450
AGEKTGLFTG LYATNPITGA KLPLFTADYV LMDYGTGAIM AVPGGDQRDY
460 470 480 490 500
DFAVKFGLPV IYTVTPLPDS GDDLANYEGK APFVSHDGIV INSSVEATEA
510 520 530 540 550
KGDALSLNGL RVDDAIAKVN AWLESAGVGK GTVSYRLRDW LFSRQRYWGE
560 570 580 590 600
PFPIVYGEDG TPHLLPDSAL PINLPDVPDY EPRTFDPMDA ESNPEAPLSR
610 620 630 640 650
NEDWVKVELD LGDGKKTYYR DTNTMPNWAG SCWYYMRYID PTDTKHMVEK
660 670 680 690 700
DEFDYWMGPN HNKYSGDEGG VDLYIGGVEH AVLHLLYSRF WHKVLFDLGY
710 720 730 740 750
VDSAEPFHKL FNQGMIQAYA YTDDRGQYVP ADEVVEGPAD ASGEPTFTWN
760 770 780 790 800
GEHANREFGK MGKSLKNIVT PDYMYENYGA DTFRLYEMSM GPLDESRPWN
810 820 830 840 850
TRNVVGGMRF LQRLWRNVVD ETTGQAHVTE DTPDEKTLKL LNNTIAEVTA
860 870 880 890 900
EMEGMRPNTA IAKLIVLNNH LTGLKAVPRA AVEPLILMLA PIAPHICEEM
910 920 930 940 950
WSKLGHAESL SAEPWPVADE RYVGHDTVTA VVQIKGKVRA KLEVPVDIDP
960 970 980
ADLEKQALAA VADRLGGKEP RKVIVKAPKI VSIVPAE
Length:987
Mass (Da):110,283
Last modified:July 22, 2008 - v1
Checksum:i9E820921AEBAA7CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA. Translation: ACD97774.1.
RefSeqiYP_001954272.1. NC_010816.1.

Genome annotation databases

EnsemblBacteriaiACD97774; ACD97774; BLD_0328.
GeneIDi6362721.
KEGGiblj:BLD_0328.
PATRICi21113582. VBIBifLon134794_0348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA. Translation: ACD97774.1 .
RefSeqi YP_001954272.1. NC_010816.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205913.BLD_0328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD97774 ; ACD97774 ; BLD_0328 .
GeneIDi 6362721.
KEGGi blj:BLD_0328.
PATRICi 21113582. VBIBifLon134794_0348.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BLON205913:GJB4-338-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
    Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
    BMC Genomics 9:247-247(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DJO10A.

Entry informationi

Entry nameiSYL_BIFLD
AccessioniPrimary (citable) accession number: B3DRD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3