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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bifidobacterium longum (strain DJO10A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei763ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BLD_0328
OrganismiBifidobacterium longum (strain DJO10A)
Taxonomic identifieri205913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000002419 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000912911 – 987Leucine--tRNA ligaseAdd BLAST987

Proteomic databases

PRIDEiB3DRD0

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 80"HIGH" regionAdd BLAST12
Motifi760 – 764"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B3DRD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNEKSTQT EEPNFRYNAA LAQDIENKWQ KIWDEQGTFW AANVNGDLKD
60 70 80 90 100
GKGRNAEGRT AYFAMDMFPY PSGKGLHVGH PLGYLASDVV SRYHRMKGEN
110 120 130 140 150
VLHAMGYDAF GLPAEQYAVQ TGQHPRVTTE ANIANMSRQL HRMGLSFDNR
160 170 180 190 200
RTFATIDPGY VRWTQWIFSR IYDSWYDEDA TNPSGSKGSA RPIAELVAKF
210 220 230 240 250
ESGEKAIPGH ESDGKQWSDL TDAEQQDILN DFRLAYISKS PVNWCPGLGT
260 270 280 290 300
VLANEEVTAE GKSERGNFPV FQRELRQWSM RITKYGHRLI ADLDGINWPE
310 320 330 340 350
KVKLMQRNWI GESHGASVHF TVATADGDKD MEIYTTRPDT LFGTTFAVVS
360 370 380 390 400
PEHHLLENVP AEWPADVPED WKGGYANPVE AVKAYRLAAE AKTAKDRVNE
410 420 430 440 450
AGEKTGLFTG LYATNPITGA KLPLFTADYV LMDYGTGAIM AVPGGDQRDY
460 470 480 490 500
DFAVKFGLPV IYTVTPLPDS GDDLANYEGK APFVSHDGIV INSSVEATEA
510 520 530 540 550
KGDALSLNGL RVDDAIAKVN AWLESAGVGK GTVSYRLRDW LFSRQRYWGE
560 570 580 590 600
PFPIVYGEDG TPHLLPDSAL PINLPDVPDY EPRTFDPMDA ESNPEAPLSR
610 620 630 640 650
NEDWVKVELD LGDGKKTYYR DTNTMPNWAG SCWYYMRYID PTDTKHMVEK
660 670 680 690 700
DEFDYWMGPN HNKYSGDEGG VDLYIGGVEH AVLHLLYSRF WHKVLFDLGY
710 720 730 740 750
VDSAEPFHKL FNQGMIQAYA YTDDRGQYVP ADEVVEGPAD ASGEPTFTWN
760 770 780 790 800
GEHANREFGK MGKSLKNIVT PDYMYENYGA DTFRLYEMSM GPLDESRPWN
810 820 830 840 850
TRNVVGGMRF LQRLWRNVVD ETTGQAHVTE DTPDEKTLKL LNNTIAEVTA
860 870 880 890 900
EMEGMRPNTA IAKLIVLNNH LTGLKAVPRA AVEPLILMLA PIAPHICEEM
910 920 930 940 950
WSKLGHAESL SAEPWPVADE RYVGHDTVTA VVQIKGKVRA KLEVPVDIDP
960 970 980
ADLEKQALAA VADRLGGKEP RKVIVKAPKI VSIVPAE
Length:987
Mass (Da):110,283
Last modified:July 22, 2008 - v1
Checksum:i9E820921AEBAA7CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA Translation: ACD97774.1
RefSeqiWP_010080746.1, NZ_AABM02000001.1

Genome annotation databases

EnsemblBacteriaiACD97774; ACD97774; BLD_0328
KEGGiblj:BLD_0328

Similar proteinsi

Entry informationi

Entry nameiSYL_BIFLD
AccessioniPrimary (citable) accession number: B3DRD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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