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B3DQN1 (MURG_BIFLD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BLD_0181
OrganismBifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]
Taxonomic identifier205913 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_1000090405

Sequences

Sequence LengthMass (Da)Tools
B3DQN1 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: DAF16113F5923AAD

FASTA39341,511
        10         20         30         40         50         60 
MNQGTPHIVL AGGGTAGHVN PLLAVAGAIR DIEPTAQVTV IGTAVGLEKD LVPEAGYELD 

        70         80         90        100        110        120 
TIEKVPFPRR PNLYMLRFPA KWKRETAKVR SILETRHADV VAGFGGYASA PVYATAHKMG 

       130        140        150        160        170        180 
IPIAIHEQNA RAGMANKLGA RWADFIGTVY EGTGLKPRAG ADVERVGLPL RPAIASLTKR 

       190        200        210        220        230        240 
IGDDRAAVRR ESAAQLGVDP NRPLVLVTGG SLGAQSLNRA IASSAADLLA HAQIIHLTGR 

       250        260        270        280        290        300 
GKISEVRELV TASAGADVLT GIGPESAGQG DYHTAEYLER IDLAFACADL VICRAGAGSV 

       310        320        330        340        350        360 
SELAALGLPA IYVPLPIGNG EQRFNAEPVV NAGGGLLVAD KDLTPQWVHE HVPDLLADHE 

       370        380        390 
RLAEFGRKAW EYGIRNAAEI MARHVLQLAE PSK

« Hide

References

[1]"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DJO10A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000605 Genomic DNA. Translation: ACD97627.1.
RefSeqYP_001954125.1. NC_010816.1.

3D structure databases

ProteinModelPortalB3DQN1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3DQN1.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6362982.
GenomeReviewsGene locus BLD_0181 in contig CP000605_GR.
KEGGblj:BLD_0181.
PATRIC21113283. VBIBifLon134794_0200.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG617076.
OMAVPLPHGN.
ProtClustDBPRK00726.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURG_BIFLD
AccessionPrimary (citable) accession number: B3DQN1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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