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B3DQM8 (MRAY_BIFLD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BLD_0178
OrganismBifidobacterium longum (strain DJO10A) [Complete proteome] [HAMAP]
Taxonomic identifier205913 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090593

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane260 – 28223Helical; Potential
Transmembrane287 – 30923Helical; Potential
Transmembrane340 – 36021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B3DQM8 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 5AB5D515BA7E1718

FASTA36840,156
        10         20         30         40         50         60 
MIALIIGMLV SLIVTLVGTP LLIRLVHKLH YGQYIRQDGP QSHLVKRGTP TLGGVVINFA 

        70         80         90        100        110        120 
ILLGWASSAL YRYLRSGDVP SWSAALVLFA MLSMGLLGFI DDFAKVRKKQ NEGLSVGGKF 

       130        140        150        160        170        180 
IGQFIFATIY AVLALLIPTK SGFPSAQAGI SFIEQPFFNF DFAGRAVAII LFVIWVNFLM 

       190        200        210        220        230        240 
TAWTNAVNLT DGLDGLAAGS SMIAFTGFGI IAFWESYHIK GGSHGGYSYA VSDPLDLTVI 

       250        260        270        280        290        300 
AVCAAVACFG FLWYNSNPAS IFMGDTGSLA LGGLFAALSI ATHTEFLAVV LGGLYVMEAM 

       310        320        330        340        350        360 
SDVIQVGYFK MTHKRVFKMA PIHHHFELEG WTETKVVVRF WMIELIFVLL ALTIFYGDWV 


TRSGLLFS

« Hide

References

[1]"Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth."
Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R., Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V., Slesarev A.I., Weimer B., O'Sullivan D.J.
BMC Genomics 9:247-247(2008) [PubMed: 18505588] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DJO10A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000605 Genomic DNA. Translation: ACD97624.1.
RefSeqYP_001954122.1. NC_010816.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB3DQM8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6362979.
GenomeReviewsGene locus BLD_0178 in contig CP000605_GR.
KEGGblj:BLD_0178.
PATRIC21113277. VBIBifLon134794_0197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMAAGGLMFY.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. False negative.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BIFLD
AccessionPrimary (citable) accession number: B3DQM8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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