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Protein

Acyl-CoA dehydrogenase family member 11

Gene

Acad11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.By similarity

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei513 – 5131Substrate; via carbonyl oxygenBy similarity
Binding sitei539 – 5391FADBy similarity
Binding sitei656 – 6561FADBy similarity
Binding sitei656 – 6561FAD; shared with dimeric partnerBy similarity
Binding sitei726 – 7261FADBy similarity
Binding sitei754 – 7541Substrate; via amide nitrogenBy similarity
Binding sitei757 – 7571FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi503 – 51311FADBy similarityAdd
BLAST
Nucleotide bindingi503 – 5064FADBy similarity
Nucleotide bindingi511 – 5133FADBy similarity
Nucleotide bindingi537 – 5393FADBy similarity
Nucleotide bindingi726 – 7305FAD; shared with dimeric partnerBy similarity
Nucleotide bindingi755 – 7573FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-RNO-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase family member 11 (EC:1.3.99.-)
Short name:
ACAD-11
Gene namesi
Name:Acad11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306270. Acad11.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial membrane Source: Ensembl
  • nucleus Source: Ensembl
  • peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Acyl-CoA dehydrogenase family member 11PRO_0000385188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751N6-acetyllysineBy similarity
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei323 – 3231PhosphotyrosineBy similarity
Modified residuei368 – 3681N6-succinyllysineBy similarity
Modified residuei390 – 3901N6-succinyllysineBy similarity
Modified residuei765 – 7651N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiB3DMA2.
PRIDEiB3DMA2.

PTM databases

iPTMnetiB3DMA2.

Expressioni

Gene expression databases

GenevisibleiB3DMA2. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036574.

Structurei

3D structure databases

ProteinModelPortaliB3DMA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni628 – 6314Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131666.
InParanoidiB3DMA2.
KOiK11730.
OMAiDWELSTT.
OrthoDBiEOG7W9RT3.
PhylomeDBiB3DMA2.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

B3DMA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMDVTRDTV EVLPQHKFDI RSLEAYLNQH LPGFGSDHRA VLTVTQYRSG
60 70 80 90 100
QSNPTFFLQK GSQAYVLRKK PPGSLLPKAH KIDREFKVQK ALFSVGFPVP
110 120 130 140 150
KPLLYCSNAS IIGTEFYVME HVQGRIFRDF SIPGVSPAER AAIYVSLVET
160 170 180 190 200
LAWLHSLDIH SLGLDRYGTG VGYCKRQVST WTKQYQASAH QSIPAMDQLS
210 220 230 240 250
TWLMRNLPDS DNEECLVHGD FKLDNIVFHP KECRVIAVLD WELSTFGHPL
260 270 280 290 300
SDLAHLSLFY FWPRTLPMIN RGSHIQENTG IPLMEELISI YCRRRGIDPN
310 320 330 340 350
LPNWNFFMAL SFFKLAGIAQ GVYSRYLMGN NSSEDSFLTA NTVQPLAETG
360 370 380 390 400
LQLSRRTLST VPPQADAKSR LFAQSRRGQE VLTRVKQFMK QHVFPAEKEV
410 420 430 440 450
AEYYAQNGNS AEKWEHPLVI EKLKEMAKAE GLWNLFLPAV SGLSQVDYAL
460 470 480 490 500
IAEETGKCFF APDVFNCQAP DTGNMEVLHL YGSEQQKQQW LEPLLRGDIT
510 520 530 540 550
SVFCMTEPNV SSSDATNMEC SIQRDGGSYI VHGKKWWSSG AGNPKCKIAV
560 570 580 590 600
VLGRTESPSV SRHKVHSMIL VPMDTPGVEL IRPLSVFGYM DNVHGGHWEV
610 620 630 640 650
HFNHVRVPAS NLILGEGRGF EISQGRLGPG RIHHCMRSVG LAERILQIMC
660 670 680 690 700
DRAVQREAFG KKLYEHEVVA HWIAKSRIAI EEIRLLTLKA AHSIDTLGSA
710 720 730 740 750
AARKEIAMIK VAAPKAVCKI ADRAIQVHGG AGVSQDYPLA NMYAIIRTLR
760 770
LADGPDEVHL SAIAKMELQD QARQLKARM
Length:779
Mass (Da):87,371
Last modified:July 22, 2008 - v1
Checksum:iEB546C2A4FB29FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473954 Genomic DNA. Translation: EDL77362.1.
BC167762 mRNA. Translation: AAI67762.1.
RefSeqiNP_001101651.1. NM_001108181.1.
UniGeneiRn.8651.

Genome annotation databases

EnsembliENSRNOT00000038383; ENSRNOP00000036574; ENSRNOG00000010940.
ENSRNOT00000081281; ENSRNOP00000072442; ENSRNOG00000010940.
GeneIDi315973.
KEGGirno:315973.
UCSCiRGD:1306270. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473954 Genomic DNA. Translation: EDL77362.1.
BC167762 mRNA. Translation: AAI67762.1.
RefSeqiNP_001101651.1. NM_001108181.1.
UniGeneiRn.8651.

3D structure databases

ProteinModelPortaliB3DMA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036574.

PTM databases

iPTMnetiB3DMA2.

Proteomic databases

PaxDbiB3DMA2.
PRIDEiB3DMA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038383; ENSRNOP00000036574; ENSRNOG00000010940.
ENSRNOT00000081281; ENSRNOP00000072442; ENSRNOG00000010940.
GeneIDi315973.
KEGGirno:315973.
UCSCiRGD:1306270. rat.

Organism-specific databases

CTDi84129.
RGDi1306270. Acad11.

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131666.
InParanoidiB3DMA2.
KOiK11730.
OMAiDWELSTT.
OrthoDBiEOG7W9RT3.
PhylomeDBiB3DMA2.

Enzyme and pathway databases

ReactomeiR-RNO-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Miscellaneous databases

NextBioi670165.
PROiB3DMA2.

Gene expression databases

GenevisibleiB3DMA2. RN.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease."
    Kikuchi M., Hatano N., Yokota S., Shimozawa N., Imanaka T., Taniguchi H.
    J. Biol. Chem. 279:421-428(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiACD11_RAT
AccessioniPrimary (citable) accession number: B3DMA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 22, 2008
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.