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Protein

Acyl-CoA dehydrogenase family member 11

Gene

Acad11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.By similarity

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei513Substrate; via carbonyl oxygenBy similarity1
Binding sitei539FADBy similarity1
Binding sitei656FADBy similarity1
Binding sitei656FAD; shared with dimeric partnerBy similarity1
Binding sitei726FADBy similarity1
Binding sitei754Substrate; via amide nitrogenBy similarity1
Binding sitei757FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi503 – 513FADBy similarityAdd BLAST11
Nucleotide bindingi503 – 506FADBy similarity4
Nucleotide bindingi511 – 513FADBy similarity3
Nucleotide bindingi537 – 539FADBy similarity3
Nucleotide bindingi726 – 730FAD; shared with dimeric partnerBy similarity5
Nucleotide bindingi755 – 757FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-RNO-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase family member 11 (EC:1.3.99.-)
Short name:
ACAD-11
Gene namesi
Name:Acad11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306270 Acad11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003851881 – 779Acyl-CoA dehydrogenase family member 11Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175N6-acetyllysineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei323PhosphotyrosineBy similarity1
Modified residuei368N6-succinyllysineBy similarity1
Modified residuei390N6-succinyllysineBy similarity1
Modified residuei765N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiB3DMA2
PeptideAtlasiB3DMA2
PRIDEiB3DMA2

PTM databases

iPTMnetiB3DMA2
PhosphoSitePlusiB3DMA2

Expressioni

Gene expression databases

BgeeiENSRNOG00000010940
GenevisibleiB3DMA2 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036574

Structurei

3D structure databases

ProteinModelPortaliB3DMA2
SMRiB3DMA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni628 – 631Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG410IIP9 Eukaryota
COG3173 LUCA
GeneTreeiENSGT00910000144198
HOGENOMiHOG000131666
InParanoidiB3DMA2
KOiK11730
OMAiIYCRCRG
PhylomeDBiB3DMA2

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR002575 Aminoglycoside_PTrfase
IPR011009 Kinase-like_dom_sf
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
PF01636 APH, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56112 SSF56112, 1 hit
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

B3DMA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMDVTRDTV EVLPQHKFDI RSLEAYLNQH LPGFGSDHRA VLTVTQYRSG
60 70 80 90 100
QSNPTFFLQK GSQAYVLRKK PPGSLLPKAH KIDREFKVQK ALFSVGFPVP
110 120 130 140 150
KPLLYCSNAS IIGTEFYVME HVQGRIFRDF SIPGVSPAER AAIYVSLVET
160 170 180 190 200
LAWLHSLDIH SLGLDRYGTG VGYCKRQVST WTKQYQASAH QSIPAMDQLS
210 220 230 240 250
TWLMRNLPDS DNEECLVHGD FKLDNIVFHP KECRVIAVLD WELSTFGHPL
260 270 280 290 300
SDLAHLSLFY FWPRTLPMIN RGSHIQENTG IPLMEELISI YCRRRGIDPN
310 320 330 340 350
LPNWNFFMAL SFFKLAGIAQ GVYSRYLMGN NSSEDSFLTA NTVQPLAETG
360 370 380 390 400
LQLSRRTLST VPPQADAKSR LFAQSRRGQE VLTRVKQFMK QHVFPAEKEV
410 420 430 440 450
AEYYAQNGNS AEKWEHPLVI EKLKEMAKAE GLWNLFLPAV SGLSQVDYAL
460 470 480 490 500
IAEETGKCFF APDVFNCQAP DTGNMEVLHL YGSEQQKQQW LEPLLRGDIT
510 520 530 540 550
SVFCMTEPNV SSSDATNMEC SIQRDGGSYI VHGKKWWSSG AGNPKCKIAV
560 570 580 590 600
VLGRTESPSV SRHKVHSMIL VPMDTPGVEL IRPLSVFGYM DNVHGGHWEV
610 620 630 640 650
HFNHVRVPAS NLILGEGRGF EISQGRLGPG RIHHCMRSVG LAERILQIMC
660 670 680 690 700
DRAVQREAFG KKLYEHEVVA HWIAKSRIAI EEIRLLTLKA AHSIDTLGSA
710 720 730 740 750
AARKEIAMIK VAAPKAVCKI ADRAIQVHGG AGVSQDYPLA NMYAIIRTLR
760 770
LADGPDEVHL SAIAKMELQD QARQLKARM
Length:779
Mass (Da):87,371
Last modified:July 22, 2008 - v1
Checksum:iEB546C2A4FB29FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473954 Genomic DNA Translation: EDL77362.1
BC167762 mRNA Translation: AAI67762.1
RefSeqiNP_001101651.1, NM_001108181.1
UniGeneiRn.8651

Genome annotation databases

EnsembliENSRNOT00000038383; ENSRNOP00000036574; ENSRNOG00000010940
ENSRNOT00000081281; ENSRNOP00000072442; ENSRNOG00000010940
GeneIDi315973
KEGGirno:315973
UCSCiRGD:1306270 rat

Similar proteinsi

Entry informationi

Entry nameiACD11_RAT
AccessioniPrimary (citable) accession number: B3DMA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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