B3DM90 (B3DM90_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ncstn protein EMBL AAI67747.1

Submitted name:
Nicastrin, isoform CRA_b EMBL EDL94676.1

Gene names

Name:	Ncstn RGD 631418 EMBL AAI67747.1
ORF Names:	rCG_20460 EMBL EDL94676.1

Organism

Rattus norvegicus (Rat) EMBL AAI67747.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	602 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	T cell proliferation Inferred from electronic annotation. Source: Compara beta-amyloid metabolic process Inferred from electronic annotation. Source: Compara epithelial cell proliferation Inferred from electronic annotation. Source: Compara myeloid cell homeostasis Inferred from electronic annotation. Source: Compara protein processing Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	endopeptidase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3DM90 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 948EF31880423A57	FASTA	602	67,170
	10 20 30 40 50 60 MEKLKGETSR IAGLAVTLAK PNSTSSFSPS VQCPNDGFGI YSNSYGPEFA HCKKTLWNEL 70 80 90 100 110 120 GNGLAYDDFS FPIFLLEDEN ETKVIKQCYQ DHNLGQNGSA PSFPLCAMQL FSHMHAVIST 130 140 150 160 170 180 ATCMRRSFIQ STFSINPEIV CDPLSDYNVW SMLKPINTSG GLEPDVRVVV AATRLDSRSF 190 200 210 220 230 240 FWNVAPGAES AVASFVTQLA AAEALHKAPD VTTLPRNVMF VFFQGETFDY IGSSRMVYDM 250 260 270 280 290 300 ENGKFPVRLE NIDSFVELGQ VALRTSLELW MHTDPMSQKN ESVKNQVEDL LVTLEQSGAD 310 320 330 340 350 360 TPQVVLSRLV QSQALPPSSL QRFLRARNIS GVVLADHSGS FHNRYYQSIY DTAENINVTY 370 380 390 400 410 420 PESQSPEEDL NFVTDTAKAL ADVATVLARA LYKLAGGTNF NNSIQADPQT VTRLLYGFLV 430 440 450 460 470 480 RANNSWFQSI LRHDLRSYLD DGPLQHYIAV SSPTNTTYVV QYALANLTGK VTNLTQEQCQ 490 500 510 520 530 540 DPSKVPNESK DLYEYSWVQG PWNSNKTERL PRCVRSTVRL ARALSPAFEL SQWSSTEYST 550 560 570 580 590 600 WAESRWKDIQ ARIFLIASKE LEFITLIVGF SILVFSLIVT YCINAKADVL FVAPREPGAV SY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI67747.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL94676.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL94676.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC167747 mRNA. Translation: AAI67747.1. CH473985 Genomic DNA. Translation: EDL94676.1.
IPI	IPI00192495.
UniGene	Rn.51975.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	631418. Ncstn.
Phylogenomic databases
HOVERGEN	HBG006497.
Gene expression databases
Genevestigator	B3DM90.
Family and domain databases
InterPro	IPR008710. Nicastrin. [Graphical view]
PANTHER	PTHR21092. PTHR21092. 1 hit.
Pfam	PF05450. Nicastrin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35565078.

Entry information

Entry name

B3DM90_RAT

Accession

Primary (citable) accession number: B3DM90

Entry history

Integrated into UniProtKB/TrEMBL:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	May 29, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)