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Protein

POU domain, class 5, transcription factor 1.3

Gene

pou5f1.3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi301 – 360HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 1.3
Alternative name(s):
POU class V protein oct-60By similarity
Gene namesi
Name:pou5f1.3
Synonyms:oct-60By similarity
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5903504. pou5f3.3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003909351 – 423POU domain, class 5, transcription factor 1.3Add BLAST423

Proteomic databases

PaxDbiB3DM23.

Interactioni

Subunit structurei

Interacts with the transcription factors tcf7l1/tcf3 and vegt.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000059598.

Structurei

3D structure databases

SMRiB3DM23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 281POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-5 subfamily.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
HOVERGENiHBG053782.
InParanoidiB3DM23.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
cd00093. HTH_XRE. 1 hit.
InterProiView protein in InterPro
IPR001387. Cro/C1-type_HTH.
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom_sf.
IPR013847. POU.
IPR000327. POU_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B3DM23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQPVLYNQP AFPNFSYSPG LGQEGGNYQY LGNYNAPSYP QPFFHVPPAI
60 70 80 90 100
KSEYGAQDEV TGGSCHAAPF DWHLYPHFQF SNQVGALSSG DPSPEGRNEE
110 120 130 140 150
DHGSISEERS SGTPSPNSPM VPSYAQYWHH APWQGNPTGQ ALGLPSRAHP
160 170 180 190 200
DGGEKPQQSD CSPTASLESG ASNTEDEEVS SALSSRAERG LCSPSPNNAS
210 220 230 240 250
FGSGNEEDGT TLEEMEEFAK ELKQKRVALG YTQGDIGHAL GILYGKMFSQ
260 270 280 290 300
TTICRFESLQ LTFKNMCKLK PLLEQWLGEA ENNDNLQEMI HKAQLEEQNR
310 320 330 340 350
KRKMRTCFDS VLKGRLEGHF MCNQKPGARE LAEIAKELGL EKDVVRVWFC
360 370 380 390 400
NRRQKEKSKS RMSKAHEFVG GASPVPSPAE HISQDYGLAP LHPNRPPFYP
410 420
PPFPRNDLFP HMVPGMSMGV LTG
Length:423
Mass (Da):46,732
Last modified:July 22, 2008 - v1
Checksum:i62D85655A840D8BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167672 mRNA. Translation: AAI67672.1.
RefSeqiNP_001123836.1. NM_001130364.1.
UniGeneiStr.52381.

Genome annotation databases

GeneIDi100170593.
KEGGixtr:100170593.

Similar proteinsi

Entry informationi

Entry nameiP5F13_XENTR
AccessioniPrimary (citable) accession number: B3DM23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: July 22, 2008
Last modified: November 22, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families