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B3DM23

- P5F13_XENTR

UniProt

B3DM23 - P5F13_XENTR

Protein

POU domain, class 5, transcription factor 1.3

Gene

pou5f1.3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi301 – 36060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. transcription factor binding Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. negative regulation of activin receptor signaling pathway Source: UniProtKB
    4. negative regulation of transcription, DNA-templated Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 5, transcription factor 1.3
    Alternative name(s):
    POU class V protein oct-60By similarity
    Gene namesi
    Name:pou5f1.3
    Synonyms:oct-60By similarity
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5903504. pou5f3.3.

    Subcellular locationi

    Nucleus By similarityPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423POU domain, class 5, transcription factor 1.3PRO_0000390935Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with the transcription factors tcf7l1/tcf3 and vegt.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini207 – 28175POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the POU transcription factor family. Class-5 subfamily.Sequence Analysis
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG053782.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3DM23-1 [UniParc]FASTAAdd to Basket

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    MDQPVLYNQP AFPNFSYSPG LGQEGGNYQY LGNYNAPSYP QPFFHVPPAI    50
    KSEYGAQDEV TGGSCHAAPF DWHLYPHFQF SNQVGALSSG DPSPEGRNEE 100
    DHGSISEERS SGTPSPNSPM VPSYAQYWHH APWQGNPTGQ ALGLPSRAHP 150
    DGGEKPQQSD CSPTASLESG ASNTEDEEVS SALSSRAERG LCSPSPNNAS 200
    FGSGNEEDGT TLEEMEEFAK ELKQKRVALG YTQGDIGHAL GILYGKMFSQ 250
    TTICRFESLQ LTFKNMCKLK PLLEQWLGEA ENNDNLQEMI HKAQLEEQNR 300
    KRKMRTCFDS VLKGRLEGHF MCNQKPGARE LAEIAKELGL EKDVVRVWFC 350
    NRRQKEKSKS RMSKAHEFVG GASPVPSPAE HISQDYGLAP LHPNRPPFYP 400
    PPFPRNDLFP HMVPGMSMGV LTG 423
    Length:423
    Mass (Da):46,732
    Last modified:July 22, 2008 - v1
    Checksum:i62D85655A840D8BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC167672 mRNA. Translation: AAI67672.1.
    RefSeqiNP_001123836.1. NM_001130364.1.
    UniGeneiStr.52381.

    Genome annotation databases

    GeneIDi100170593.
    KEGGixtr:100170593.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC167672 mRNA. Translation: AAI67672.1 .
    RefSeqi NP_001123836.1. NM_001130364.1.
    UniGenei Str.52381.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100170593.
    KEGGi xtr:100170593.

    Organism-specific databases

    CTDi 397936.
    Xenbasei XB-GENE-5903504. pou5f3.3.

    Phylogenomic databases

    HOVERGENi HBG053782.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: GastrulaImported.

    Entry informationi

    Entry nameiP5F13_XENTR
    AccessioniPrimary (citable) accession number: B3DM23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3