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B3DM23 (P5F13_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 5, transcription factor 1.3
Alternative name(s):
POU class V protein oct-60
Gene names
Name:pou5f1.3
Synonyms:oct-60
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA By similarity. UniProtKB Q91989

Subunit structure

Interacts with the transcription factors tcf7l1/tcf3 and vegt By similarity. UniProtKB Q91989

Subcellular location

Nucleus By similarity UniProtKB Q01860.

Sequence similarities

Belongs to the POU transcription factor family. Class-5 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
RNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of activin receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionRNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423POU domain, class 5, transcription factor 1.3
PRO_0000390935

Regions

Domain207 – 28175POU-specific
DNA binding301 – 36060Homeobox

Sequences

Sequence LengthMass (Da)Tools
B3DM23 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 62D85655A840D8BD

FASTA42346,732
        10         20         30         40         50         60 
MDQPVLYNQP AFPNFSYSPG LGQEGGNYQY LGNYNAPSYP QPFFHVPPAI KSEYGAQDEV 

        70         80         90        100        110        120 
TGGSCHAAPF DWHLYPHFQF SNQVGALSSG DPSPEGRNEE DHGSISEERS SGTPSPNSPM 

       130        140        150        160        170        180 
VPSYAQYWHH APWQGNPTGQ ALGLPSRAHP DGGEKPQQSD CSPTASLESG ASNTEDEEVS 

       190        200        210        220        230        240 
SALSSRAERG LCSPSPNNAS FGSGNEEDGT TLEEMEEFAK ELKQKRVALG YTQGDIGHAL 

       250        260        270        280        290        300 
GILYGKMFSQ TTICRFESLQ LTFKNMCKLK PLLEQWLGEA ENNDNLQEMI HKAQLEEQNR 

       310        320        330        340        350        360 
KRKMRTCFDS VLKGRLEGHF MCNQKPGARE LAEIAKELGL EKDVVRVWFC NRRQKEKSKS 

       370        380        390        400        410        420 
RMSKAHEFVG GASPVPSPAE HISQDYGLAP LHPNRPPFYP PPFPRNDLFP HMVPGMSMGV 


LTG 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC167672 mRNA. Translation: AAI67672.1.
RefSeqNP_001123836.1. NM_001130364.1.
UniGeneStr.52381.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100170593.
KEGGxtr:100170593.

Organism-specific databases

CTD397936.
XenbaseXB-GENE-5903504. pou5f3.3.

Phylogenomic databases

HOVERGENHBG053782.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP5F13_XENTR
AccessionPrimary (citable) accession number: B3DM23
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: July 22, 2008
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families