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Protein

POU domain, class 5, transcription factor 1.3

Gene

pou5f1.3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi301 – 36060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. transcription factor binding Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. negative regulation of activin receptor signaling pathway Source: UniProtKB
  4. negative regulation of transcription, DNA-templated Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 1.3
Alternative name(s):
POU class V protein oct-60By similarity
Gene namesi
Name:pou5f1.3
Synonyms:oct-60By similarity
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5903504. pou5f3.3.

Subcellular locationi

Nucleus By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423POU domain, class 5, transcription factor 1.3PRO_0000390935Add
BLAST

Interactioni

Subunit structurei

Interacts with the transcription factors tcf7l1/tcf3 and vegt.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 28175POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-5 subfamily.Sequence Analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053782.
InParanoidiB3DM23.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DM23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQPVLYNQP AFPNFSYSPG LGQEGGNYQY LGNYNAPSYP QPFFHVPPAI
60 70 80 90 100
KSEYGAQDEV TGGSCHAAPF DWHLYPHFQF SNQVGALSSG DPSPEGRNEE
110 120 130 140 150
DHGSISEERS SGTPSPNSPM VPSYAQYWHH APWQGNPTGQ ALGLPSRAHP
160 170 180 190 200
DGGEKPQQSD CSPTASLESG ASNTEDEEVS SALSSRAERG LCSPSPNNAS
210 220 230 240 250
FGSGNEEDGT TLEEMEEFAK ELKQKRVALG YTQGDIGHAL GILYGKMFSQ
260 270 280 290 300
TTICRFESLQ LTFKNMCKLK PLLEQWLGEA ENNDNLQEMI HKAQLEEQNR
310 320 330 340 350
KRKMRTCFDS VLKGRLEGHF MCNQKPGARE LAEIAKELGL EKDVVRVWFC
360 370 380 390 400
NRRQKEKSKS RMSKAHEFVG GASPVPSPAE HISQDYGLAP LHPNRPPFYP
410 420
PPFPRNDLFP HMVPGMSMGV LTG
Length:423
Mass (Da):46,732
Last modified:July 22, 2008 - v1
Checksum:i62D85655A840D8BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167672 mRNA. Translation: AAI67672.1.
RefSeqiNP_001123836.1. NM_001130364.1.
UniGeneiStr.52381.

Genome annotation databases

GeneIDi100170593.
KEGGixtr:100170593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167672 mRNA. Translation: AAI67672.1.
RefSeqiNP_001123836.1. NM_001130364.1.
UniGeneiStr.52381.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100170593.
KEGGixtr:100170593.

Organism-specific databases

CTDi397936.
XenbaseiXB-GENE-5903504. pou5f3.3.

Phylogenomic databases

HOVERGENiHBG053782.
InParanoidiB3DM23.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: GastrulaImported.

Entry informationi

Entry nameiP5F13_XENTR
AccessioniPrimary (citable) accession number: B3DM23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: July 22, 2008
Last modified: January 7, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.