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B3DLI0

- B3DLI0_XENTR

UniProt

B3DLI0 - B3DLI0_XENTR

Protein
Submitted name:

Cbl protein

Gene

cbl

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. signal transducer activity Source: InterPro
    3. ubiquitin-protein transferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: InterPro
    2. regulation of signaling Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_195701. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_205645. EGFR downregulation.
    REACT_211544. Spry regulation of FGF signaling.
    REACT_214782. Negative regulation of FGFR signaling.
    REACT_216093. Interleukin-6 signaling.
    REACT_216102. Signaling by constitutively active EGFR.
    REACT_219006. Regulation of KIT signaling.
    REACT_221188. TGF-beta receptor signaling activates SMADs.
    REACT_223361. Regulation of signaling by CBL.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cbl proteinImported
    Gene namesi
    Name:cblImported
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

    Organism-specific databases

    XenbaseiXB-GENE-6258452. cbl.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Expressioni

    Gene expression databases

    BgeeiB3DLI0.

    Structurei

    3D structure databases

    ProteinModelPortaliB3DLI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Zinc-fingerUniRule annotation

    Phylogenomic databases

    eggNOGiNOG242251.
    HOVERGENiHBG005255.
    KOiK04707.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.20.930.20. 1 hit.
    3.30.40.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR024162. Adaptor_Cbl.
    IPR014741. Adaptor_Cbl_EF_hand-like.
    IPR003153. Adaptor_Cbl_N_hlx.
    IPR014742. Adaptor_Cbl_SH2-like.
    IPR024159. Cbl_PTB.
    IPR011992. EF-hand-dom_pair.
    IPR000980. SH2.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PANTHERiPTHR23007. PTHR23007. 1 hit.
    PfamiPF02262. Cbl_N. 1 hit.
    PF02761. Cbl_N2. 1 hit.
    PF02762. Cbl_N3. 1 hit.
    PF00627. UBA. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF47668. SSF47668. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS51506. CBL_PTB. 1 hit.
    PS50030. UBA. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3DLI0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATNLRKGGG LIGLVKDAFQ PHHHHPTAQP GAVDRKTVEK CWKLMDKVVR    50
    LCQNQRLALK NSPPYILDLL PDTYQHLRTI MSRYEGKMEI LGENEYFRVF 100
    MENLLKKTKQ TISLFKEGKE RMYEENSQPR RNLTKLSLIF SHMLAELKAI 150
    FPNGQFQGDS FRITKADAAE FWRKAFGEKT IVPWKIFRLA LHDVHPISSG 200
    LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWSSLLRNW NSLAVTHPGY 250
    MAFLTYDEVK ARLQKFIHKP GSYIFRLSCT RLGQWAIGYV TGDGNILQTI 300
    PHNKPLFQAL IDGFREGFYL FPDGRNQNPD LTGLCEPTPQ DHIKVTQEQY 350
    ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTSW QESEGQGCPF 400
    CRCEIKGTEP IVVDPFDPRG GGMAELLRHC MDGTPSPCYD DDDDDSGNDS 450
    IFVMKELAGA KVERPPSPLS ATPQASLPPV PPRLDLLPQR APNQSGACSP 500
    ATSSKASSSS HHKDKPLPVP PTLRDLPPPP PPDRPHSMPC ESRPQRRPLP 550
    STPAEKPLPL PTNRPGETWH PRAVPKAPAS NLTPGDPWTG GRELTNRHSL 600
    PFTLPSHIDE RRDRHGSTQS LDNTGISATT ELFGGLDNDD AKMKPSSSAN 650
    AIYSLATRPF PVSKPPTGDH VDSGDESEYM CPSSRPLIPA AVPKSEARRP 700
    LETLPGLRPP DQQTERESYE TMYNIQCQAT NPVVVEPSRE EETNSAIANN 750
    GPENDDNEED GYDIPKPHLP MAPARRTMSD APNATPAFCS GAIGRDSGAG 800
    LLESSQVPER PPKPFPRRMN SERRSVVGGG SGDAPPAPLS SEIESLLSQG 850
    YSQQDVNKAL LIAHNNIEMA RNILREFVSI PSPAHVAT 888
    Length:888
    Mass (Da):98,562
    Last modified:July 22, 2008 - v1
    Checksum:iFEE51C20A0F5847E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC167455 mRNA. Translation: AAI67455.1.
    RefSeqiNP_001122110.1. NM_001128638.1.
    UniGeneiStr.1437.

    Genome annotation databases

    GeneIDi594900.
    KEGGixtr:594900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC167455 mRNA. Translation: AAI67455.1 .
    RefSeqi NP_001122110.1. NM_001128638.1.
    UniGenei Str.1437.

    3D structure databases

    ProteinModelPortali B3DLI0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 594900.
    KEGGi xtr:594900.

    Organism-specific databases

    CTDi 867.
    Xenbasei XB-GENE-6258452. cbl.

    Phylogenomic databases

    eggNOGi NOG242251.
    HOVERGENi HBG005255.
    KOi K04707.

    Enzyme and pathway databases

    Reactomei REACT_195701. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_205645. EGFR downregulation.
    REACT_211544. Spry regulation of FGF signaling.
    REACT_214782. Negative regulation of FGFR signaling.
    REACT_216093. Interleukin-6 signaling.
    REACT_216102. Signaling by constitutively active EGFR.
    REACT_219006. Regulation of KIT signaling.
    REACT_221188. TGF-beta receptor signaling activates SMADs.
    REACT_223361. Regulation of signaling by CBL.

    Gene expression databases

    Bgeei B3DLI0.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.20.930.20. 1 hit.
    3.30.40.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR024162. Adaptor_Cbl.
    IPR014741. Adaptor_Cbl_EF_hand-like.
    IPR003153. Adaptor_Cbl_N_hlx.
    IPR014742. Adaptor_Cbl_SH2-like.
    IPR024159. Cbl_PTB.
    IPR011992. EF-hand-dom_pair.
    IPR000980. SH2.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    PANTHERi PTHR23007. PTHR23007. 1 hit.
    Pfami PF02262. Cbl_N. 1 hit.
    PF02761. Cbl_N2. 1 hit.
    PF02762. Cbl_N3. 1 hit.
    PF00627. UBA. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF47668. SSF47668. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS51506. CBL_PTB. 1 hit.
    PS50030. UBA. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestesImported.

    Entry informationi

    Entry nameiB3DLI0_XENTR
    AccessioniPrimary (citable) accession number: B3DLI0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)