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B3DLI0

- B3DLI0_XENTR

UniProt

B3DLI0 - B3DLI0_XENTR

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Protein
Submitted name:

Cbl protein

Gene

cbl

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. signal transducer activity Source: InterPro
  3. ubiquitin-protein transferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_195701. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_205645. EGFR downregulation.
REACT_211544. Spry regulation of FGF signaling.
REACT_214782. Negative regulation of FGFR signaling.
REACT_216093. Interleukin-6 signaling.
REACT_216102. Signaling by constitutively active EGFR.
REACT_219006. Regulation of KIT signaling.
REACT_221188. TGF-beta receptor signaling activates SMADs.
REACT_223361. Regulation of signaling by CBL.

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proteinImported
Gene namesi
Name:cblImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-6258452. cbl.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiB3DLI0.
ExpressionAtlasiB3DLI0. baseline.

Structurei

3D structure databases

ProteinModelPortaliB3DLI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiNOG242251.
HOVERGENiHBG005255.
KOiK04707.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DLI0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATNLRKGGG LIGLVKDAFQ PHHHHPTAQP GAVDRKTVEK CWKLMDKVVR
60 70 80 90 100
LCQNQRLALK NSPPYILDLL PDTYQHLRTI MSRYEGKMEI LGENEYFRVF
110 120 130 140 150
MENLLKKTKQ TISLFKEGKE RMYEENSQPR RNLTKLSLIF SHMLAELKAI
160 170 180 190 200
FPNGQFQGDS FRITKADAAE FWRKAFGEKT IVPWKIFRLA LHDVHPISSG
210 220 230 240 250
LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWSSLLRNW NSLAVTHPGY
260 270 280 290 300
MAFLTYDEVK ARLQKFIHKP GSYIFRLSCT RLGQWAIGYV TGDGNILQTI
310 320 330 340 350
PHNKPLFQAL IDGFREGFYL FPDGRNQNPD LTGLCEPTPQ DHIKVTQEQY
360 370 380 390 400
ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTSW QESEGQGCPF
410 420 430 440 450
CRCEIKGTEP IVVDPFDPRG GGMAELLRHC MDGTPSPCYD DDDDDSGNDS
460 470 480 490 500
IFVMKELAGA KVERPPSPLS ATPQASLPPV PPRLDLLPQR APNQSGACSP
510 520 530 540 550
ATSSKASSSS HHKDKPLPVP PTLRDLPPPP PPDRPHSMPC ESRPQRRPLP
560 570 580 590 600
STPAEKPLPL PTNRPGETWH PRAVPKAPAS NLTPGDPWTG GRELTNRHSL
610 620 630 640 650
PFTLPSHIDE RRDRHGSTQS LDNTGISATT ELFGGLDNDD AKMKPSSSAN
660 670 680 690 700
AIYSLATRPF PVSKPPTGDH VDSGDESEYM CPSSRPLIPA AVPKSEARRP
710 720 730 740 750
LETLPGLRPP DQQTERESYE TMYNIQCQAT NPVVVEPSRE EETNSAIANN
760 770 780 790 800
GPENDDNEED GYDIPKPHLP MAPARRTMSD APNATPAFCS GAIGRDSGAG
810 820 830 840 850
LLESSQVPER PPKPFPRRMN SERRSVVGGG SGDAPPAPLS SEIESLLSQG
860 870 880
YSQQDVNKAL LIAHNNIEMA RNILREFVSI PSPAHVAT
Length:888
Mass (Da):98,562
Last modified:July 22, 2008 - v1
Checksum:iFEE51C20A0F5847E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC167455 mRNA. Translation: AAI67455.1.
RefSeqiNP_001122110.1. NM_001128638.1.
UniGeneiStr.1437.

Genome annotation databases

GeneIDi594900.
KEGGixtr:594900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC167455 mRNA. Translation: AAI67455.1 .
RefSeqi NP_001122110.1. NM_001128638.1.
UniGenei Str.1437.

3D structure databases

ProteinModelPortali B3DLI0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 594900.
KEGGi xtr:594900.

Organism-specific databases

CTDi 867.
Xenbasei XB-GENE-6258452. cbl.

Phylogenomic databases

eggNOGi NOG242251.
HOVERGENi HBG005255.
KOi K04707.

Enzyme and pathway databases

Reactomei REACT_195701. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_205645. EGFR downregulation.
REACT_211544. Spry regulation of FGF signaling.
REACT_214782. Negative regulation of FGFR signaling.
REACT_216093. Interleukin-6 signaling.
REACT_216102. Signaling by constitutively active EGFR.
REACT_219006. Regulation of KIT signaling.
REACT_221188. TGF-beta receptor signaling activates SMADs.
REACT_223361. Regulation of signaling by CBL.

Gene expression databases

Bgeei B3DLI0.
ExpressionAtlasi B3DLI0. baseline.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
PANTHERi PTHR23007. PTHR23007. 1 hit.
Pfami PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestesImported.

Entry informationi

Entry nameiB3DLI0_XENTR
AccessioniPrimary (citable) accession number: B3DLI0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)