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Protein
Submitted name:

Cbl protein

Gene

cbl

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_272606. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_273806. Spry regulation of FGF signaling.
REACT_273983. TGF-beta receptor signaling activates SMADs.
REACT_278275. Regulation of KIT signaling.
REACT_289185. Interleukin-6 signaling.
REACT_299272. EGFR downregulation.
REACT_301315. Regulation of signaling by CBL.
REACT_358129. Negative regulation of FGFR3 signaling.
REACT_358220. Negative regulation of FGFR4 signaling.
REACT_361240. Negative regulation of FGFR1 signaling.
REACT_362440. Negative regulation of FGFR2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proteinImported
Gene namesi
Name:cblImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-6258452. cbl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiB3DLI0.
ExpressionAtlasiB3DLI0. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000046653.

Structurei

3D structure databases

ProteinModelPortaliB3DLI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiNOG242251.
HOVERGENiHBG005255.
KOiK04707.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DLI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATNLRKGGG LIGLVKDAFQ PHHHHPTAQP GAVDRKTVEK CWKLMDKVVR
60 70 80 90 100
LCQNQRLALK NSPPYILDLL PDTYQHLRTI MSRYEGKMEI LGENEYFRVF
110 120 130 140 150
MENLLKKTKQ TISLFKEGKE RMYEENSQPR RNLTKLSLIF SHMLAELKAI
160 170 180 190 200
FPNGQFQGDS FRITKADAAE FWRKAFGEKT IVPWKIFRLA LHDVHPISSG
210 220 230 240 250
LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWSSLLRNW NSLAVTHPGY
260 270 280 290 300
MAFLTYDEVK ARLQKFIHKP GSYIFRLSCT RLGQWAIGYV TGDGNILQTI
310 320 330 340 350
PHNKPLFQAL IDGFREGFYL FPDGRNQNPD LTGLCEPTPQ DHIKVTQEQY
360 370 380 390 400
ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTSW QESEGQGCPF
410 420 430 440 450
CRCEIKGTEP IVVDPFDPRG GGMAELLRHC MDGTPSPCYD DDDDDSGNDS
460 470 480 490 500
IFVMKELAGA KVERPPSPLS ATPQASLPPV PPRLDLLPQR APNQSGACSP
510 520 530 540 550
ATSSKASSSS HHKDKPLPVP PTLRDLPPPP PPDRPHSMPC ESRPQRRPLP
560 570 580 590 600
STPAEKPLPL PTNRPGETWH PRAVPKAPAS NLTPGDPWTG GRELTNRHSL
610 620 630 640 650
PFTLPSHIDE RRDRHGSTQS LDNTGISATT ELFGGLDNDD AKMKPSSSAN
660 670 680 690 700
AIYSLATRPF PVSKPPTGDH VDSGDESEYM CPSSRPLIPA AVPKSEARRP
710 720 730 740 750
LETLPGLRPP DQQTERESYE TMYNIQCQAT NPVVVEPSRE EETNSAIANN
760 770 780 790 800
GPENDDNEED GYDIPKPHLP MAPARRTMSD APNATPAFCS GAIGRDSGAG
810 820 830 840 850
LLESSQVPER PPKPFPRRMN SERRSVVGGG SGDAPPAPLS SEIESLLSQG
860 870 880
YSQQDVNKAL LIAHNNIEMA RNILREFVSI PSPAHVAT
Length:888
Mass (Da):98,562
Last modified:July 22, 2008 - v1
Checksum:iFEE51C20A0F5847E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167455 mRNA. Translation: AAI67455.1.
RefSeqiNP_001122110.1. NM_001128638.1.
UniGeneiStr.1437.

Genome annotation databases

GeneIDi594900.
KEGGixtr:594900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167455 mRNA. Translation: AAI67455.1.
RefSeqiNP_001122110.1. NM_001128638.1.
UniGeneiStr.1437.

3D structure databases

ProteinModelPortaliB3DLI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000046653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi594900.
KEGGixtr:594900.

Organism-specific databases

CTDi867.
XenbaseiXB-GENE-6258452. cbl.

Phylogenomic databases

eggNOGiNOG242251.
HOVERGENiHBG005255.
KOiK04707.

Enzyme and pathway databases

ReactomeiREACT_272606. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_273806. Spry regulation of FGF signaling.
REACT_273983. TGF-beta receptor signaling activates SMADs.
REACT_278275. Regulation of KIT signaling.
REACT_289185. Interleukin-6 signaling.
REACT_299272. EGFR downregulation.
REACT_301315. Regulation of signaling by CBL.
REACT_358129. Negative regulation of FGFR3 signaling.
REACT_358220. Negative regulation of FGFR4 signaling.
REACT_361240. Negative regulation of FGFR1 signaling.
REACT_362440. Negative regulation of FGFR2 signaling.

Gene expression databases

BgeeiB3DLI0.
ExpressionAtlasiB3DLI0. baseline.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestesImported.

Entry informationi

Entry nameiB3DLI0_XENTR
AccessioniPrimary (citable) accession number: B3DLI0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 22, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.