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B3DLI0

- B3DLI0_XENTR

UniProt

B3DLI0 - B3DLI0_XENTR

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Protein
Submitted name: Cbl protein
Gene
cbl
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. signal transducer activity Source: InterPro
  3. ubiquitin-protein transferase activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_195701. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_205645. EGFR downregulation.
REACT_211544. Spry regulation of FGF signaling.
REACT_214782. Negative regulation of FGFR signaling.
REACT_216093. Interleukin-6 signaling.
REACT_216102. Signaling by constitutively active EGFR.
REACT_219006. Regulation of KIT signaling.
REACT_221188. TGF-beta receptor signaling activates SMADs.
REACT_223361. Regulation of signaling by CBL.

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proteinImported
Gene namesi
Name:cblImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-6258452. cbl.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiB3DLI0.

Structurei

3D structure databases

ProteinModelPortaliB3DLI0.

Family & Domainsi

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiNOG242251.
HOVERGENiHBG005255.
KOiK04707.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DLI0-1 [UniParc]FASTAAdd to Basket

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MATNLRKGGG LIGLVKDAFQ PHHHHPTAQP GAVDRKTVEK CWKLMDKVVR    50
LCQNQRLALK NSPPYILDLL PDTYQHLRTI MSRYEGKMEI LGENEYFRVF 100
MENLLKKTKQ TISLFKEGKE RMYEENSQPR RNLTKLSLIF SHMLAELKAI 150
FPNGQFQGDS FRITKADAAE FWRKAFGEKT IVPWKIFRLA LHDVHPISSG 200
LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWSSLLRNW NSLAVTHPGY 250
MAFLTYDEVK ARLQKFIHKP GSYIFRLSCT RLGQWAIGYV TGDGNILQTI 300
PHNKPLFQAL IDGFREGFYL FPDGRNQNPD LTGLCEPTPQ DHIKVTQEQY 350
ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTSW QESEGQGCPF 400
CRCEIKGTEP IVVDPFDPRG GGMAELLRHC MDGTPSPCYD DDDDDSGNDS 450
IFVMKELAGA KVERPPSPLS ATPQASLPPV PPRLDLLPQR APNQSGACSP 500
ATSSKASSSS HHKDKPLPVP PTLRDLPPPP PPDRPHSMPC ESRPQRRPLP 550
STPAEKPLPL PTNRPGETWH PRAVPKAPAS NLTPGDPWTG GRELTNRHSL 600
PFTLPSHIDE RRDRHGSTQS LDNTGISATT ELFGGLDNDD AKMKPSSSAN 650
AIYSLATRPF PVSKPPTGDH VDSGDESEYM CPSSRPLIPA AVPKSEARRP 700
LETLPGLRPP DQQTERESYE TMYNIQCQAT NPVVVEPSRE EETNSAIANN 750
GPENDDNEED GYDIPKPHLP MAPARRTMSD APNATPAFCS GAIGRDSGAG 800
LLESSQVPER PPKPFPRRMN SERRSVVGGG SGDAPPAPLS SEIESLLSQG 850
YSQQDVNKAL LIAHNNIEMA RNILREFVSI PSPAHVAT 888
Length:888
Mass (Da):98,562
Last modified:July 22, 2008 - v1
Checksum:iFEE51C20A0F5847E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC167455 mRNA. Translation: AAI67455.1.
RefSeqiNP_001122110.1. NM_001128638.1.
UniGeneiStr.1437.

Genome annotation databases

GeneIDi594900.
KEGGixtr:594900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC167455 mRNA. Translation: AAI67455.1 .
RefSeqi NP_001122110.1. NM_001128638.1.
UniGenei Str.1437.

3D structure databases

ProteinModelPortali B3DLI0.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 594900.
KEGGi xtr:594900.

Organism-specific databases

CTDi 867.
Xenbasei XB-GENE-6258452. cbl.

Phylogenomic databases

eggNOGi NOG242251.
HOVERGENi HBG005255.
KOi K04707.

Enzyme and pathway databases

Reactomei REACT_195701. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_205645. EGFR downregulation.
REACT_211544. Spry regulation of FGF signaling.
REACT_214782. Negative regulation of FGFR signaling.
REACT_216093. Interleukin-6 signaling.
REACT_216102. Signaling by constitutively active EGFR.
REACT_219006. Regulation of KIT signaling.
REACT_221188. TGF-beta receptor signaling activates SMADs.
REACT_223361. Regulation of signaling by CBL.

Gene expression databases

Bgeei B3DLI0.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
PANTHERi PTHR23007. PTHR23007. 1 hit.
Pfami PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestesImported.

Entry informationi

Entry nameiB3DLI0_XENTR
AccessioniPrimary (citable) accession number: B3DLI0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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