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Protein

Protein arginine N-methyltransferase 2

Gene

prmt2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as histones. Involved in growth regulation. Involved in embryonic dorsal development.By similarity

Catalytic activityi

2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115S-adenosyl-L-methionineBy similarity1
Binding sitei124S-adenosyl-L-methionineBy similarity1
Binding sitei148S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei171S-adenosyl-L-methionineBy similarity1
Binding sitei200S-adenosyl-L-methionineBy similarity1
Active sitei214By similarity1
Active sitei223By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2 (EC:2.1.1.319By similarity)
Alternative name(s):
Histone-arginine N-methyltransferase PRMT2
Gene namesi
Name:prmt2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-980934. prmt2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004041561 – 433Protein arginine N-methyltransferase 2Add BLAST433

Proteomic databases

PaxDbiB3DLB3.

Expressioni

Gene expression databases

BgeeiENSXETG00000031494.
ExpressionAtlasiB3DLB3. differential.

Interactioni

Subunit structurei

Interacts with ctnnb1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000062304.

Structurei

3D structure databases

ProteinModelPortaliB3DLB3.
SMRiB3DLB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 89SH3PROSITE-ProRule annotationAdd BLAST60
Domaini102 – 416SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST315

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase PRMT-type domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410ITIK. Eukaryota.
ENOG410Z57Q. LUCA.
GeneTreeiENSGT00550000074406.
HOVERGENiHBG105734.
InParanoidiB3DLB3.
KOiK11435.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025799. Arg_MeTrfase.
IPR029063. SAM-dependent_MTases.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11006. PTHR11006. 1 hit.
PfamiPF05185. PRMT5. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51678. SAM_MT_PRMT. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B3DLB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTSGCSSEK SDFQDSTEGE EEEDTQSENL CMREYVVIRD YMAADATQLS
60 70 80 90 100
LCFGDKVLLL SAVTQDWWWV KHNGICGYVP ASYLHDALND QEDTEVDDPW
110 120 130 140 150
QDEEYYGSYK TLKLHLEMLS DVPRTTAYKE VILRNSSSLC GKHILDLGCG
160 170 180 190 200
TGIISFFCAK LAQPEAVYAV EASEIAEQTR RLVKQNGISN LVHVIRQRAE
210 220 230 240 250
ELQLPTKVDI LVSEWMGTCL LFEFMLESVL QARDRWLKED GVMWPSTACI
260 270 280 290 300
HLVPCSASKE YANKVLFWDN PYQLDFSLLK PLAAKEFFAR PKPDYVLQPE
310 320 330 340 350
DCLSEPCILL HLNLKTLQLA ELERMNSDFT FFVHTDGLLH GFTAWFSVQF
360 370 380 390 400
QNLEEQGQLE LNTGPFSPLT HWKHTLFMLD EPLQVQKGDK ISGSVVFQRN
410 420 430
SVWRRHMSVT LSWVINGKLT MQNVSQQWQA ILA
Length:433
Mass (Da):49,519
Last modified:July 22, 2008 - v1
Checksum:i54B827FE81323C89
GO
Isoform 2 (identifier: B3DLB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-433: RMNSDFTFFV...VSQQWQAILA → VRAILSNLH

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):37,763
Checksum:iAE75814F33C89920
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040525324 – 433RMNSD…QAILA → VRAILSNLH in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124052 mRNA. Translation: AAI24053.1.
BC167381 mRNA. Translation: AAI67381.1.
RefSeqiNP_001072706.2. NM_001079238.2.
UniGeneiStr.67552.

Genome annotation databases

EnsembliENSXETT00000065355; ENSXETP00000060978; ENSXETG00000031494. [B3DLB3-2]
GeneIDi780163.
KEGGixtr:780163.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124052 mRNA. Translation: AAI24053.1.
BC167381 mRNA. Translation: AAI67381.1.
RefSeqiNP_001072706.2. NM_001079238.2.
UniGeneiStr.67552.

3D structure databases

ProteinModelPortaliB3DLB3.
SMRiB3DLB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000062304.

Proteomic databases

PaxDbiB3DLB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000065355; ENSXETP00000060978; ENSXETG00000031494. [B3DLB3-2]
GeneIDi780163.
KEGGixtr:780163.

Organism-specific databases

CTDi3275.
XenbaseiXB-GENE-980934. prmt2.

Phylogenomic databases

eggNOGiENOG410ITIK. Eukaryota.
ENOG410Z57Q. LUCA.
GeneTreeiENSGT00550000074406.
HOVERGENiHBG105734.
InParanoidiB3DLB3.
KOiK11435.

Gene expression databases

BgeeiENSXETG00000031494.
ExpressionAtlasiB3DLB3. differential.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025799. Arg_MeTrfase.
IPR029063. SAM-dependent_MTases.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11006. PTHR11006. 1 hit.
PfamiPF05185. PRMT5. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51678. SAM_MT_PRMT. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANM2_XENTR
AccessioniPrimary (citable) accession number: B3DLB3
Secondary accession number(s): Q08CW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.