Reviewed, UniProtKB/Swiss-Prot B3DL53 (NDK6_XENTR)

Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase 6
      Short name=NDP kinase 6
      Short name=NDK 6
    EC=2.7.4.6

Gene names

Name:

nme6

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Nucleoside diphosphate kinase 6		PRO_0000369547
Sites
	Active site	128	1	Pros-phosphohistidine intermediate By similarity
	Binding site	18	1	ATP By similarity
	Binding site	67	1	ATP By similarity
	Binding site	95	1	ATP By similarity
	Binding site	101	1	ATP By similarity
	Binding site	115	1	ATP By similarity
	Binding site	125	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3DL53-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: C2AC7D0472CD10B2	FASTA	179	21,027
	10 20 30 40 50 60 MSSFRWVRPL QLTLALIKPD AVANPVISEA VHQKILENNF LIIRHKELHW RSTDSQRFYC 70 80 90 100 110 120 EHKGRFFYQR LVEFMSSGPM QAYILAHEDA VQLWRNLMGP TKVFRARIVA PGTVRGDLGL 130 140 150 160 170 TDTRNTTHGS DSVESACREI TFFFPEFNTS DWYEKQEPRY RTGPVFYDEE RSEHRLEGE

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC167315 mRNA. Translation: AAI67315.1.
RefSeq	NP_001123709.1.
UniGene	Str.31723
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100170458.
KEGG	xtr:100170458.
Organism-specific databases
CTD	100170458.
Xenbase	XB-FEAT-969917. nme6.
Family and domain databases
InterPro	IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK6_XENTR

Accession

Primary (citable) accession number: B3DL53

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	September 1, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project