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Protein

Nucleoside diphosphate kinase 6

Gene

nme6

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.PROSITE-ProRule annotation

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181ATPBy similarity
Binding sitei67 – 671ATPBy similarity
Binding sitei95 – 951ATPBy similarity
Binding sitei101 – 1011ATPBy similarity
Binding sitei115 – 1151ATPBy similarity
Binding sitei125 – 1251ATPBy similarity
Active sitei128 – 1281Pros-phosphohistidine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 6 (EC:2.7.4.6)
Short name:
NDK 6
Short name:
NDP kinase 6
Gene namesi
Name:nme6
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-969918. nme6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Nucleoside diphosphate kinase 6PRO_0000369547Add
BLAST

Proteomic databases

PaxDbiB3DL53.

Expressioni

Gene expression databases

BgeeiB3DL53.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000034257.

Structurei

3D structure databases

ProteinModelPortaliB3DL53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224565.
InParanoidiB3DL53.
KOiK00940.
OMAiGKFFYHR.
OrthoDBiEOG7QZGCP.
TreeFamiTF354225.

Family and domain databases

InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3DL53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFRWVRPL QLTLALIKPD AVANPVISEA VHQKILENNF LIIRHKELHW
60 70 80 90 100
RSTDSQRFYC EHKGRFFYQR LVEFMSSGPM QAYILAHEDA VQLWRNLMGP
110 120 130 140 150
TKVFRARIVA PGTVRGDLGL TDTRNTTHGS DSVESACREI TFFFPEFNTS
160 170
DWYEKQEPRY RTGPVFYDEE RSEHRLEGE
Length:179
Mass (Da):21,027
Last modified:July 22, 2008 - v1
Checksum:iC2AC7D0472CD10B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167315 mRNA. Translation: AAI67315.1.
RefSeqiNP_001123709.1. NM_001130237.1.
XP_012814101.1. XM_012958647.1.
XP_012814102.1. XM_012958648.1.
UniGeneiStr.31723.

Genome annotation databases

EnsembliENSXETT00000034257; ENSXETP00000034257; ENSXETG00000015714.
GeneIDi100170458.
KEGGixtr:100170458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167315 mRNA. Translation: AAI67315.1.
RefSeqiNP_001123709.1. NM_001130237.1.
XP_012814101.1. XM_012958647.1.
XP_012814102.1. XM_012958648.1.
UniGeneiStr.31723.

3D structure databases

ProteinModelPortaliB3DL53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000034257.

Proteomic databases

PaxDbiB3DL53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000034257; ENSXETP00000034257; ENSXETG00000015714.
GeneIDi100170458.
KEGGixtr:100170458.

Organism-specific databases

CTDi10201.
XenbaseiXB-GENE-969918. nme6.

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224565.
InParanoidiB3DL53.
KOiK00940.
OMAiGKFFYHR.
OrthoDBiEOG7QZGCP.
TreeFamiTF354225.

Gene expression databases

BgeeiB3DL53.

Family and domain databases

InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNDK6_XENTR
AccessioniPrimary (citable) accession number: B3DL53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: February 17, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.