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Protein
Submitted name:

Epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

Gene

epm2a

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-XTR-3322077. Glycogen synthesis.

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

Names & Taxonomyi

Protein namesi
Submitted name:
Epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)Imported
Submitted name:
LOC100170449 proteinImported
Gene namesi
Name:epm2aImported
Synonyms:LOC100170449Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-965638. epm2a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneSAAS annotation

Expressioni

Gene expression databases

BgeeiENSXETG00000017691.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000038390.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 113CBM20InterPro annotationAdd BLAST113
Domaini138 – 285Tyrosine-protein phosphataseInterPro annotationAdd BLAST148
Domaini225 – 293TYR_PHOSPHATASE_2InterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00390000010101.
HOGENOMiHOG000285975.
HOVERGENiHBG051493.
OMAiGHTDEMK.
OrthoDBiEOG091G0GBM.
TreeFamiTF332841.

Family and domain databases

CDDicd05806. CBM20_laforin. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR013784. Carb-bd-like_fold.
IPR034831. CBM20_laforin.
IPR002044. CBM_fam20.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00686. CBM_20. 1 hit.
PF00782. DSPc. 1 hit.
SMARTiView protein in SMART
SM01065. CBM_2. 1 hit.
SM00195. DSPc. 1 hit.
SUPFAMiSSF49452. SSF49452. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS51166. CBM20. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

B3DL33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRFGVIIT LNHSDNELLV LGSRKEMGSW DPQYAVPMKP TRCPLSTTEP
60 70 80 90 100
SFWVGEVLLE EPYTDTFWFK FIKKESGALI WEGNGPHHDR CCVFNESNIV
110 120 130 140 150
DGVYCHPVGH WIETTGHTDE MKHTTDFYFH FAGTQAMHFS RILPNIWLGS
160 170 180 190 200
CPRQREHVTV KMKHELGVTA VLNFQTEWDV IQNSSGCNNY PEPMSPETMF
210 220 230 240 250
RLYKEAGITY IWIPTPDMST EGRIRMLPQA VYLLFGLLEN GHTVYVHCNA
260 270 280 290 300
GVGRSTAAVC GFLMYVIGWS LRKVQYFLAS RRPAVYIDEE AMINAQEDFH
310
KKFGHLRSTV CRI
Length:313
Mass (Da):35,982
Last modified:July 22, 2008 - v1
Checksum:i51F67CB470174E74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01033867 Genomic DNA. No translation available.
BC167294 mRNA. Translation: AAI67294.1.
BC167295 mRNA. Translation: AAI67295.1.
RefSeqiNP_001123695.1. NM_001130223.1.
UniGeneiStr.36893.

Genome annotation databases

EnsembliENSXETT00000038390; ENSXETP00000038390; ENSXETG00000017691.
GeneIDi100170449.

Similar proteinsi

Entry informationi

Entry nameiB3DL33_XENTR
AccessioniPrimary (citable) accession number: B3DL33
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 22, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported