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B3DK56 (PTPRU_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase U
Short name=R-PTP-U
EC=3.1.3.48
Alternative name(s):
Receptor-type protein-tyrosine phosphatase psi
Short name=R-PTP-psi
Gene names
Name:ptpru
Synonyms:rptppsi
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length1444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. Functions in somitogenesis. Functions as a regulator of the biochemical clock responsible for the segmentation of the presomitic mesoderm. Ref.1

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cell junction By similarity. Cell membrane; Single-pass type I membrane protein By similarity.

Developmental stage

First detected in somites, pronephric duct, midbrain hindbrain boundary, otic vesicle and retina 10-24 after fertilization. When somite formation is complete expression becomes restricted to the retina, the forebrain midbrain, the midbrain hindbrain boundary, the otic vesicle and the branchial arches. Ref.1

Miscellaneous

Embryos lacking ptpru display severe disruption of their segmental pattern and loss of cyclic gene expression in the presomitic mesoderm. Convergent extension during gastrulation is also affected.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.

Contains 4 fibronectin type-III domains.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 MAM domain.

Contains 2 tyrosine-protein phosphatase domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B3DK56-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B3DK56-2)

The sequence of this isoform differs from the canonical sequence as follows:
     773-782: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 14441428Receptor-type tyrosine-protein phosphatase U
PRO_0000371661

Regions

Topological domain17 – 748732Extracellular Potential
Transmembrane749 – 76921Helical; Potential
Topological domain770 – 1444675Cytoplasmic Potential
Domain24 – 184161MAM
Domain186 – 27186Ig-like C2-type
Domain281 – 37393Fibronectin type-III 1
Domain379 – 480102Fibronectin type-III 2
Domain486 – 58499Fibronectin type-III 3
Domain597 – 67781Fibronectin type-III 4
Domain886 – 1142257Tyrosine-protein phosphatase 1
Domain1174 – 1437264Tyrosine-protein phosphatase 2
Region1083 – 10897Substrate binding By similarity

Sites

Active site10831Phosphocysteine intermediate By similarity
Active site13781Phosphocysteine intermediate By similarity
Binding site10511Substrate Potential
Binding site11271Substrate By similarity

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential
Glycosylation6841N-linked (GlcNAc...) Potential
Disulfide bond206 ↔ 260 Potential

Natural variations

Alternative sequence773 – 78210Missing in isoform 2.
VSP_037087

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: A4C3CDAFFD3D88B1

FASTA1,444162,661
        10         20         30         40         50         60 
MNTCAFLLIL AVQIHADSVE GPTAGCTFDE DSDPSLCEFS QGEEDDFDWQ LFRAHASPHS 

        70         80         90        100        110        120 
TSDLLRGSYM MVNSSQHAAG QRAQLLLQTL SENDTHCVQF SYFLYSRDGH SPGALRVYVR 

       130        140        150        160        170        180 
VNGGPLGIPV WNVSGSRGRQ WHQVELAVST FWPNEYQILL EATVDRKGYI AVDDILLLNY 

       190        200        210        220        230        240 
PCYKAPHFSR LGDVEVNAGQ NATFQCVAAG RPSEAEKFLL ERHNGEVSSG GSVKHLGRNR 

       250        260        270        280        290        300 
FAVSFQLEDV QKPEQDLYRC VTQSSRGSGV SNFAELIVKV PPSPIAPPQL LRAGSTYLII 

       310        320        330        340        350        360 
QLNTNSILGD GPIIRREIEY RASLAPWSEI LGVNMVTYKL WHLDPDTEYH ISVLLTRPGE 

       370        380        390        400        410        420 
GGTGPPGPPL ISRTKCAEPM RALRGLRASE IQSRQLTLQW EVPAFNLTRC HTYSVSLCYR 

       430        440        450        460        470        480 
YTTAGGGGGH NTTVRECLAV EHNTSRFTLR DLPPFHTIQI RLALANTEGK KEGKEVMFQT 

       490        500        510        520        530        540 
EEDIPGGIAP ESLTFTPLED MIFLKWEEPV EPNGLITQYE ISYQSIESSD PGINVPGPRR 

       550        560        570        580        590        600 
TVSKLKNETY HMFSNLHPGT TYLISVRART AKGFGQTALT EITTNISAPT FDYGDMPSPL 

       610        620        630        640        650        660 
SETENTITVL LRPAQGRGAP VSTYQVVVEE EAGRKVKREL GIQDCFPIPT SHGEAQARGA 

       670        680        690        700        710        720 
PHYYTAELPP SSLSEATPFT VGDNHTYNGY WNSPLDPRKN YLVYFQAMSN FRGETRINCI 

       730        740        750        760        770        780 
RIARKAACKD HQRALEVTQR SEEMGLILGV CAGGLVVLIL LLGAIIIIIK KGRDYYSYSY 

       790        800        810        820        830        840 
YPRKPGNMNK TPITYRQEKS NMMGSMERSF TDQSTLQEDE RMALSFMDTH TCSTRSDPRS 

       850        860        870        880        890        900 
SMNESSSLLG GSPRRQCGRK GSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF 

       910        920        930        940        950        960 
FDGWDINKKK DKTKGRHDTL MGYDRHRVKL HPLLGDPNSD YINANYIDGY HRSNHFIATQ 

       970        980        990       1000       1010       1020 
GPKQETVYDF WRMVWQENCF SIVMITKLVE VGRVKCCKYW PDESEMYGDI KITLLKTETL 

      1030       1040       1050       1060       1070       1080 
AEYTVRTFAL ERRGYSAKHE VCQFHFTSWP EHGVPYHATG LLAFIRRVKT STPLDAGPVV 

      1090       1100       1110       1120       1130       1140 
VHCSVGAGRT GCYIVLDVML DMAECEGVVD IYNCVKTLCS RRINMIQTEE QYIFIHDAIL 

      1150       1160       1170       1180       1190       1200 
EACLCGETAI PVNEFALAYK EMLRVDSQSN SSQLREEFQT LNSVTPHLDV EECSIALLPR 

      1210       1220       1230       1240       1250       1260 
NREKNRSMDV LPPDRALAFL VTTEGESNNY INAALMDSFH RPAAFIVTPH PLPGTTSDFW 

      1270       1280       1290       1300       1310       1320 
RLVFDYGCTS VVMLNQLNQS NSAWPCVQYW PEPGLQQYGP MQVEFLSMSA DEDIITRLFR 

      1330       1340       1350       1360       1370       1380 
VKNVTRLQEG QLVVCQFQFL RWSAYRDVPD SKKAFLNLLA SVQKWQRECG EGRTVVHCLN 

      1390       1400       1410       1420       1430       1440 
GGGRSGTYCA SNILMEMIQY QNIVDVFYAV KTLRNAKPNM VETLEQYRFC YELVLEYLDC 


LEVR

« Hide

Isoform 2 [UniParc].

Checksum: 527A7B61CBA4443A
Show »

FASTA1,434161,302

References

« Hide 'large scale' references
[1]"Receptor tyrosine phosphatase psi is required for delta/notch signalling and cyclic gene expression in the presomitic mesoderm."
Aerne B., Ish-Horowicz D.
Development 131:3391-3399(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, DEVELOPMENTAL STAGE.
Tissue: Embryo.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY555586 mRNA. Translation: AAT37515.1.
BC163712 mRNA. Translation: AAI63712.1.
BC163727 mRNA. Translation: AAI63727.1.
IPIIPI00498780.
IPI00817273.
RefSeqNP_001002299.1. NM_001002299.1.
UniGeneDr.20078.

3D structure databases

ProteinModelPortalB3DK56.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID335096.
KEGGdre:335096.

Organism-specific databases

CTD335096.
ZFINZDB-GENE-030131-7036. ptprub.

Phylogenomic databases

eggNOGNOG311686.
HOGENOMHOG000049029.
InParanoidQ6E5N7.
KOK16662.
OrthoDBEOG4868BM.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 1 hit.
SSF49265. FN_III-like. 3 hits.
PROSITEPS50853. FN3. 4 hits.
PS50835. IG_LIKE. False negative.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20810666.

Entry information

Entry namePTPRU_DANRE
AccessionPrimary (citable) accession number: B3DK56
Secondary accession number(s): Q6E5N7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 22, 2008
Last modified: March 6, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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