B3CV39 (B3CV39_ORITI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Coproporphyrinogen III oxidase EMBL BAG41236.1

Gene names

Name:	hemF EMBL BAG41236.1
Ordered Locus Names:	OTT_1778

Organism

Orientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi) [Complete proteome] [HAMAP]

Taxonomic identifier

334380 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Orientia

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. SAAS SAAS001260
Catalytic activity	Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. SAAS SAAS001260
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. SAAS SAAS001260
Subunit structure	Homodimer By similarity. SAAS SAAS001260

Ontologies

Keywords
Biological process	Porphyrin biosynthesis SAAS SAAS001260
Molecular function	Oxidoreductase SAAS SAAS001260
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3CV39 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 6AC9F2F8A61275E6	FASTA	278	32,004
	10 20 30 40 50 60 MIEYQEKCYQ WFKELRDELI KAFELIEQHY ASSKKVKVAK FSQSQWSRAG GGGGEMSIMR 70 80 90 100 110 120 GNVFAKVGVN ISKVYGDMPI ALCDIIPCTN YSSNFFATGI SVVAHMKSPL VPAVHFNTRY 130 140 150 160 170 180 LETNNYWFGG GSDLTPLYPD KLETKKFHQA FQVVCDKYNP SYYEKFKAEC DNYFYLPHRK 190 200 210 220 230 240 EVRGVGGVFY DYLNSKNFDI DFNFTKSIGE AFLAIYPDIV KSKMFLPWSN SQYEALLVKR 250 260 270 GRYVEFNLLY DRGTKFGLMT DGNVDAILMS LPPEVKWP

References

[1]

"The whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution." Nakayama K., Yamashita A., Kurokawa K., Morimoto T., Ogawa M., Fukuhara M., Urakami H., Ohnishi M., Uchiyama I., Ogura Y., Ooka T., Oshima K., Tamura A., Hattori M., Hayashi T. DNA Res. 15:185-199(2008) [PubMed: 18508905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008981 Genomic DNA. Translation: BAG41236.1.
RefSeq	YP_001938470.1. NC_010793.1.
3D structure databases
ProteinModelPortal	B3CV39.
ModBase	Search...
Protein-protein interaction databases
STRING	B3CV39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6337898.
GenomeReviews	Gene locus OTT_1778 in contig AP008981_GR.
KEGG	ott:OTT_1778.
PATRIC	22829970. VBIOriTsu129072_1992.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG631180.
OMA	ARICAEL.
ProtClustDB	PRK05330.
Family and domain databases
InterPro	IPR001260. Coprogen_oxidase_aer. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KO	K00228.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
SUPFAM	SSF102886. Coprogen_oxidas. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B3CV39_ORITI

Accession

Primary (citable) accession number: B3CV39

Entry history

Integrated into UniProtKB/TrEMBL:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)