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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Orientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciOTSU334380:GC7O-1670-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Name:icdImported
Ordered Locus Names:OTT_1639Imported
OrganismiOrientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi)Imported
Taxonomic identifieri334380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
ProteomesiUP000001033 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiQCCDEVA.
OrthoDBiEOG65XN31.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.

Sequencei

Sequence statusi: Complete.

B3CUQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVIPVTIA YGDGIGPEIM EAVVYVLKEA AVPLRLETIE IGEKLYNKYY
60 70 80 90 100
TYGITEDTWS QIFRTKALLK GPVTTPQGEG YKSLNVTLKK TLGLYANVRP
110 120 130 140 150
SISYFPFVNT SAPEIDVVII RENEEDLYTG IEYHHTADTY ESIKLISRSG
160 170 180 190 200
SEKIIRFAFE YALKNNRKKI SCFSKDNIMK FTDGIFHNTF NEIASQYSNI
210 220 230 240 250
QVDHYLIDIG SARLISSPQK FDVIVTSNLY GDILSDIAAE ISDSIGLAGS
260 270 280 290 300
ANIGKDYAMF EAVHGSAPDI AGQNIANPSG LLNAAIMMLV HLGLTEHAAK
310 320 330 340 350
IENALKKTIE DGIHTADIYN PSISSKKVGT KEFAQAIINN LEYKPKKLKI
360 370 380 390 400
AEYHNLDVES NIINNSQIQT ITETRQQKKL VGVDVFFDSH NIIDYHRITK
410 420 430 440 450
QLTKRIASLS SLHGMHLVTI SAKGLKLWPN STVREMFSDH WCCRFMVQSS
460 470 480 490 500
GKDKTVTAKN LTMKDILSLL NDLVATINNP IHSESKDDNY DNSIKFELIK
510
VENLYLFNDT VGFSLAQGE
Length:519
Mass (Da):58,017
Last modified:July 22, 2008 - v1
Checksum:iDEBA2724BB059684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008981 Genomic DNA. Translation: BAG41097.1.
RefSeqiWP_012462089.1. NC_010793.1.

Genome annotation databases

EnsemblBacteriaiBAG41097; BAG41097; OTT_1639.
KEGGiott:OTT_1639.
PATRICi22829652. VBIOriTsu129072_1835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008981 Genomic DNA. Translation: BAG41097.1.
RefSeqiWP_012462089.1. NC_010793.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG41097; BAG41097; OTT_1639.
KEGGiott:OTT_1639.
PATRICi22829652. VBIOriTsu129072_1835.

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiQCCDEVA.
OrthoDBiEOG65XN31.

Enzyme and pathway databases

BioCyciOTSU334380:GC7O-1670-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution."
    Nakayama K., Yamashita A., Kurokawa K., Morimoto T., Ogawa M., Fukuhara M., Urakami H., Ohnishi M., Uchiyama I., Ogura Y., Ooka T., Oshima K., Tamura A., Hattori M., Hayashi T.
    DNA Res. 15:185-199(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IkedaImported.

Entry informationi

Entry nameiB3CUQ0_ORITI
AccessioniPrimary (citable) accession number: B3CUQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.