ID   B3CUM6_ORITI            Unreviewed;       295 AA.
AC   B3CUM6;
DT   22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase {ECO:0000313|EMBL:BAG41073.1};
GN   Name=dapD {ECO:0000313|EMBL:BAG41073.1};
GN   OrderedLocusNames=OTT_1615 {ECO:0000313|EMBL:BAG41073.1};
OS   Orientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=334380 {ECO:0000313|EMBL:BAG41073.1, ECO:0000313|Proteomes:UP000001033};
RN   [1] {ECO:0000313|Proteomes:UP000001033}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ikeda {ECO:0000313|Proteomes:UP000001033};
RX   PubMed=18508905; DOI=10.1093/dnares/dsn011;
RA   Nakayama K., Yamashita A., Kurokawa K., Morimoto T., Ogawa M., Fukuhara M.,
RA   Urakami H., Ohnishi M., Uchiyama I., Ogura Y., Ooka T., Oshima K.,
RA   Tamura A., Hattori M., Hayashi T.;
RT   "The whole-genome sequencing of the obligate intracellular bacterium
RT   Orientia tsutsugamushi revealed massive gene amplification during reductive
RT   genome evolution.";
RL   DNA Res. 15:185-199(2008).
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000256|ARBA:ARBA00007274}.
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DR   EMBL; AP008981; BAG41073.1; -; Genomic_DNA.
DR   AlphaFoldDB; B3CUM6; -.
DR   KEGG; ott:OTT_1615; -.
DR   HOGENOM; CLU_050859_0_1_5; -.
DR   Proteomes; UP000001033; Chromosome.
DR   GO; GO:0008666; F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity; IEA:InterPro.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR   CDD; cd03350; LbH_THP_succinylT; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   Gene3D; 1.10.166.10; Tetrahydrodipicolinate-N-succinyltransferase, N-terminal domain; 1.
DR   InterPro; IPR005664; DapD_Trfase_Hexpep_rpt_fam.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR023180; THP_succinylTrfase_dom1.
DR   InterPro; IPR037133; THP_succinylTrfase_N_sf.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   NCBIfam; TIGR00965; dapD; 1.
DR   PANTHER; PTHR43300:SF10; 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATE N-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR43300; ACETYLTRANSFERASE; 1.
DR   Pfam; PF14602; Hexapep_2; 1.
DR   Pfam; PF14805; THDPS_N_2; 1.
DR   SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Diaminopimelate biosynthesis {ECO:0000256|ARBA:ARBA00022915};
KW   Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW   Transferase {ECO:0000313|EMBL:BAG41073.1}.
FT   DOMAIN          25..89
FT                   /note="Tetrahydrodipicolinate-N-succinyltransferase chain
FT                   A"
FT                   /evidence="ECO:0000259|Pfam:PF14805"
SQ   SEQUENCE   295 AA;  32481 MW;  3A230B00AC2CD389 CRC64;
     MFKGFLKYRV NIMEKNTGKL YKYINKVEDF WTKRNQLIKG AEDYKVACRW LQSILDDLDK
     GIVRACEKKH GEWHTNEWVK KAILLYFKLH DSVLTSTQVA CYYDKIPLKF YSSGSEEDNF
     KELGIRVVPG AIIRKGAYIG HSTVIMPSFI NIGAYVGSGT MIDSWATVGS CAYVGNKCHI
     SGGVGLGGVL EPIQNASVIV EDNCFIGARS QIAEGVIVES GAVIGTGVQI SASTKIVDRE
     TGEVTYGRIP ANSVVVPGSL PQPYSNNIQL QCAVIIKKVD NNTRAKTSIN DLLRC
//