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B3CQC3

- PGK_ORITI

UniProt

B3CQC3 - PGK_ORITI

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Orientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371SubstrateUniRule annotation
Binding sitei119 – 1191SubstrateUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Binding sitei202 – 2021ATPUniRule annotation
Binding sitei325 – 3251ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi355 – 3584ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOTSU334380:GC7O-4-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:OTT_0004
OrganismiOrientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi)
Taxonomic identifieri334380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
ProteomesiUP000001033: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Phosphoglycerate kinasePRO_1000096362Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi334380.OTT_0004.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 243Substrate bindingUniRule annotation
Regioni60 – 634Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

B3CQC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQLRQLSDV IVKDKVVLLR LDLNIPQEGG KITDNTRIVR TIPTIKYLIL
60 70 80 90 100
HGAKVVIISH LGNPKGRIEL TLSLRSVVTE LEALLNIKVQ FCPESIGSTP
110 120 130 140 150
KNAIIKMKAG EVLLLENLRF NSGEELNDAT FVNELSSLGD IYVNDAFSCS
160 170 180 190 200
HRKHASICGL PAKLPSAAGF LLLSELKHLT SIFSNANKPF TVIIGGAKMS
210 220 230 240 250
TKLDLLNSLI TKADYLIVAG AMANIFLAMK RFNIGASLYK PELVNVASLI
260 270 280 290 300
LKKATSTNCK IILPFDAVIQ NFNSNNITII ELNSSLVMQS NAKIMDIGPK
310 320 330 340 350
TIAQIINIIK ISKTIVWNGP VGAFEQLPFD HGSTYLSKAI AEKTRTGSLC
360 370 380 390 400
SVAGGGDTIS AIKKSGVIDD FSYISTGGGA FLEWLQGKTL PGVEALMQKL

DTAKYI
Length:406
Mass (Da):43,938
Last modified:July 22, 2008 - v1
Checksum:iC5F929A68ADC8039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008981 Genomic DNA. Translation: BAG39462.1.
RefSeqiWP_012460728.1. NC_010793.1.
YP_001936696.1. NC_010793.1.

Genome annotation databases

EnsemblBacteriaiBAG39462; BAG39462; OTT_0004.
GeneIDi6337820.
KEGGiott:OTT_0004.
PATRICi22825930. VBIOriTsu129072_0004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008981 Genomic DNA. Translation: BAG39462.1 .
RefSeqi WP_012460728.1. NC_010793.1.
YP_001936696.1. NC_010793.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 334380.OTT_0004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG39462 ; BAG39462 ; OTT_0004 .
GeneIDi 6337820.
KEGGi ott:OTT_0004.
PATRICi 22825930. VBIOriTsu129072_0004.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
KOi K00927.
OMAi AGHPVGK.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci OTSU334380:GC7O-4-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution."
    Nakayama K., Yamashita A., Kurokawa K., Morimoto T., Ogawa M., Fukuhara M., Urakami H., Ohnishi M., Uchiyama I., Ogura Y., Ooka T., Oshima K., Tamura A., Hattori M., Hayashi T.
    DNA Res. 15:185-199(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ikeda.

Entry informationi

Entry nameiPGK_ORITI
AccessioniPrimary (citable) accession number: B3CQC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3