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B3CNK5

- SYE1_WOLPP

UniProt

B3CNK5 - SYE1_WOLPP

Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei241 – 2411ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciWEND570417:GHSW-168-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetase 1UniRule annotation
    Short name:
    GluRS 1UniRule annotation
    Gene namesi
    Name:gltX1UniRule annotation
    Ordered Locus Names:WP0166
    OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
    Taxonomic identifieri570417 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000008814: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Glutamate--tRNA ligase 1PRO_0000367794Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi570417.WPa_0166.

    Structurei

    3D structure databases

    ProteinModelPortaliB3CNK5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi7 – 1711"HIGH" regionAdd
    BLAST
    Motifi238 – 2425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    KOiK01885.
    OMAiGHIYACY.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3CNK5-1 [UniParc]FASTAAdd to Basket

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    MLTRFAPSPT GYLHVGNIRT ALICWMYTRN QNGKFLLRFD DTDLERSDIK    50
    YVDNIIEDLK WIGINWNSSF KQSERFERYN EVFLQLMKEG HIYACYETRE 100
    ELDTKRKLQL KQGFPPVYDK GALLLTEQEK IRYEQEGRKP HFRFKLDRNK 150
    TVKWNDEVKG EINIATIHIS DPVVKREDGI YTYMLPSVID DIDFNVTHVV 200
    RGEDHVTNTA VQIQMIQALK AKIPIFAHLP LLHFDDSKIS KRKGGLDIKS 250
    IREDEIESMA LTSYLAKLGT SDPIEAYIDM QSLIDSFDIK KFSSASLQFS 300
    LSEMYKLNSK VLQQMPFEMV QDRLSQIGSE FWYFIRSNIE KFSEVAKWWK 350
    ICKFGIEPVV LNKEFIKIAL STLPQGDCNE NTLSEWVKNI RQTIDIKAKD 400
    LFMQLRLALT GTETGPELAK LLIFIGRESI IARLEESQRI IQKV 444
    Length:444
    Mass (Da):51,763
    Last modified:July 22, 2008 - v1
    Checksum:i476AD5A7FBF60089
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM999887 Genomic DNA. Translation: CAQ54274.1.
    RefSeqiYP_001974983.1. NC_010981.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ54274; CAQ54274; WP0166.
    GeneIDi6385170.
    KEGGiwpi:WPa_0166.
    PATRICi24025860. VBIWolEnd95846_0183.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM999887 Genomic DNA. Translation: CAQ54274.1 .
    RefSeqi YP_001974983.1. NC_010981.1.

    3D structure databases

    ProteinModelPortali B3CNK5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 570417.WPa_0166.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ54274 ; CAQ54274 ; WP0166 .
    GeneIDi 6385170.
    KEGGi wpi:WPa_0166.
    PATRICi 24025860. VBIWolEnd95846_0183.

    Phylogenomic databases

    eggNOGi COG0008.
    KOi K01885.
    OMAi GHIYACY.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci WEND570417:GHSW-168-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: wPip.

    Entry informationi

    Entry nameiSYE1_WOLPP
    AccessioniPrimary (citable) accession number: B3CNK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3