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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:WP0166
OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
Taxonomic identifieri570417 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000008814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677941 – 444Glutamate--tRNA ligase 1Add BLAST444

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi570417.WPa_0166

Structurei

3D structure databases

ProteinModelPortaliB3CNK5
SMRiB3CNK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 17"HIGH" regionUniRule annotationAdd BLAST11
Motifi238 – 242"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B3CNK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRFAPSPT GYLHVGNIRT ALICWMYTRN QNGKFLLRFD DTDLERSDIK
60 70 80 90 100
YVDNIIEDLK WIGINWNSSF KQSERFERYN EVFLQLMKEG HIYACYETRE
110 120 130 140 150
ELDTKRKLQL KQGFPPVYDK GALLLTEQEK IRYEQEGRKP HFRFKLDRNK
160 170 180 190 200
TVKWNDEVKG EINIATIHIS DPVVKREDGI YTYMLPSVID DIDFNVTHVV
210 220 230 240 250
RGEDHVTNTA VQIQMIQALK AKIPIFAHLP LLHFDDSKIS KRKGGLDIKS
260 270 280 290 300
IREDEIESMA LTSYLAKLGT SDPIEAYIDM QSLIDSFDIK KFSSASLQFS
310 320 330 340 350
LSEMYKLNSK VLQQMPFEMV QDRLSQIGSE FWYFIRSNIE KFSEVAKWWK
360 370 380 390 400
ICKFGIEPVV LNKEFIKIAL STLPQGDCNE NTLSEWVKNI RQTIDIKAKD
410 420 430 440
LFMQLRLALT GTETGPELAK LLIFIGRESI IARLEESQRI IQKV
Length:444
Mass (Da):51,763
Last modified:July 22, 2008 - v1
Checksum:i476AD5A7FBF60089
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM999887 Genomic DNA Translation: CAQ54274.1
RefSeqiWP_007302690.1, NC_010981.1

Genome annotation databases

EnsemblBacteriaiCAQ54274; CAQ54274; WP0166
GeneIDi33018978
KEGGiwpi:WP0166

Similar proteinsi

Entry informationi

Entry nameiSYE1_WOLPP
AccessioniPrimary (citable) accession number: B3CNK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: February 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health