SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B3CN77

- PYRF_WOLPP

UniProt

B3CN77 - PYRF_WOLPP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, WP0101
Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Substrate By similarity
Binding sitei31 – 311Substrate By similarity
Active sitei60 – 601Proton donor By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei176 – 1761Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei204 – 2041Substrate; via amide nitrogen By similarity
Binding sitei205 – 2051Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciWEND570417:GHSW-102-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:WP0101
OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
Taxonomic identifieri570417 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008814: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_1000138569Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi570417.WPa_0101.

Structurei

3D structure databases

ProteinModelPortaliB3CN77.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 6710Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiHAKEPRE.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3CN77-1 [UniParc]FASTAAdd to Basket

« Hide

MNPIICALDT QDLNEAISWA NGLRDKVGMV KLGLEFFAAH GPSGVREVAK    50
CNVPIFLDLK LYDIPNTVAR TVEAIKALDV EMLTLHISGG TKMLKEALSI 100
VQGKKIKLIG VTVLTSMGNE DLSELGVARE AKSQVILLAK LAKKIGLHGV 150
VCSALEAQEV RQECGKDFKI ITPGIRMNRG HDDQKRTATP KEAINSGADY 200
IVIGRPITES SNPASSAELI LKSLTD 226
Length:226
Mass (Da):24,328
Last modified:July 22, 2008 - v1
Checksum:iFC0068A91581CCD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM999887 Genomic DNA. Translation: CAQ54209.1.
RefSeqiYP_001974925.1. NC_010981.1.

Genome annotation databases

EnsemblBacteriaiCAQ54209; CAQ54209; WP0101.
GeneIDi6384331.
KEGGiwpi:WPa_0101.
PATRICi24025716. VBIWolEnd95846_0112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM999887 Genomic DNA. Translation: CAQ54209.1 .
RefSeqi YP_001974925.1. NC_010981.1.

3D structure databases

ProteinModelPortali B3CN77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 570417.WPa_0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ54209 ; CAQ54209 ; WP0101 .
GeneIDi 6384331.
KEGGi wpi:WPa_0101.
PATRICi 24025716. VBIWolEnd95846_0112.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi HAKEPRE.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci WEND570417:GHSW-102-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: wPip.

Entry informationi

Entry nameiPYRF_WOLPP
AccessioniPrimary (citable) accession number: B3CN77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi