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B3CM21

- PNP_WOLPP

UniProt

B3CM21 - PNP_WOLPP

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi482 – 4821MagnesiumUniRule annotation
    Metal bindingi488 – 4881MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciWEND570417:GHSW-847-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:WP0831
    OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
    Taxonomic identifieri570417 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000008814: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758Polyribonucleotide nucleotidyltransferasePRO_1000192505Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi570417.WPa_0831.

    Structurei

    3D structure databases

    ProteinModelPortaliB3CM21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini549 – 60860KHUniRule annotationAdd
    BLAST
    Domaini618 – 68669S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    KOiK00962.
    OMAiHGNFKSN.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3CM21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFEIIKKSID WEGRTLSLET GKIARQADGS VVVNYGDTSI LVTVVRKKKE    50
    ESVDFLPLNV QFIAKSYAMG KIPGGFFKRE GKPSDRETLI SRVIDRSIRP 100
    LFPEGFHDEI SVVCNLLTYD TVNSPEVPAL IGTVAALAIS GVPFHFTIAG 150
    VMVGCDENNN YILNPSVQEM KASNLDLFLS GDENSILMVE SEVKELSEEN 200
    VLNAIKFGHE HLQPVIKLIK EFADTVGNKP ESFAPVDISD ITQELEKYRK 250
    DFEEAYSKTV KQERVQALEV VRNNILNTLK EAGKDEKLIT YAVKSFERSL 300
    VREMIRRKSV RIDSRKYDEI RQIEIEADIL PKTHGSALFT RGSTQALVVT 350
    ALGTTQDEQI VDDIEGDRRE HFMLHYNFPP FAVGEASAIR APGRREIGHG 400
    KLAWKAIHPV LPDKSEFPYT IRVVSEIMES DGSSSMATVC GTSIALMDTG 450
    VPIKAPVAGI AMGLIKDKNE HIILSDILGD EDYLGDMDFK VAGTSEGITA 500
    LQMDMKIPGI SFEIVEKSLE QAKVGRLHIL EKMNAVISEH RKDIKDHVPR 550
    VLSFYIDKDK ISAAIGTKGK NIRSVCERSN AKIEIGDDGK VSVFAISSTE 600
    AEAAKNMMID SITELEQGSI IDAKVVKIEK SIVELELLNG RKGKMHISEV 650
    ANQHVESIED ILKQGDTFKA LIIDFEKGGC PKLSRRRVDQ ETGEFFEGKL 700
    YNEERRDGLN NRDNYYNNSF NKKPEDNYHS NRPTRPRSGF SNRSRPKFGN 750
    NDSSSGFY 758
    Length:758
    Mass (Da):84,663
    Last modified:July 22, 2008 - v1
    Checksum:i256402174A833358
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM999887 Genomic DNA. Translation: CAQ54939.1.
    RefSeqiYP_001975589.1. NC_010981.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ54939; CAQ54939; WP0831.
    GeneIDi6384667.
    KEGGiwpi:WPa_0831.
    PATRICi24027348. VBIWolEnd95846_0913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM999887 Genomic DNA. Translation: CAQ54939.1 .
    RefSeqi YP_001975589.1. NC_010981.1.

    3D structure databases

    ProteinModelPortali B3CM21.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 570417.WPa_0831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ54939 ; CAQ54939 ; WP0831 .
    GeneIDi 6384667.
    KEGGi wpi:WPa_0831.
    PATRICi 24027348. VBIWolEnd95846_0913.

    Phylogenomic databases

    eggNOGi COG1185.
    KOi K00962.
    OMAi HGNFKSN.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci WEND570417:GHSW-847-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: wPip.

    Entry informationi

    Entry nameiPNP_WOLPP
    AccessioniPrimary (citable) accession number: B3CM21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3