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B3CM21

- PNP_WOLPP

UniProt

B3CM21 - PNP_WOLPP

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi482 – 4821MagnesiumUniRule annotation
Metal bindingi488 – 4881MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciWEND570417:GHSW-847-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:WP0831
OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
Taxonomic identifieri570417 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008814: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Polyribonucleotide nucleotidyltransferasePRO_1000192505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi570417.WPa_0831.

Structurei

3D structure databases

ProteinModelPortaliB3CM21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 60860KHUniRule annotationAdd
BLAST
Domaini618 – 68669S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3CM21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFEIIKKSID WEGRTLSLET GKIARQADGS VVVNYGDTSI LVTVVRKKKE
60 70 80 90 100
ESVDFLPLNV QFIAKSYAMG KIPGGFFKRE GKPSDRETLI SRVIDRSIRP
110 120 130 140 150
LFPEGFHDEI SVVCNLLTYD TVNSPEVPAL IGTVAALAIS GVPFHFTIAG
160 170 180 190 200
VMVGCDENNN YILNPSVQEM KASNLDLFLS GDENSILMVE SEVKELSEEN
210 220 230 240 250
VLNAIKFGHE HLQPVIKLIK EFADTVGNKP ESFAPVDISD ITQELEKYRK
260 270 280 290 300
DFEEAYSKTV KQERVQALEV VRNNILNTLK EAGKDEKLIT YAVKSFERSL
310 320 330 340 350
VREMIRRKSV RIDSRKYDEI RQIEIEADIL PKTHGSALFT RGSTQALVVT
360 370 380 390 400
ALGTTQDEQI VDDIEGDRRE HFMLHYNFPP FAVGEASAIR APGRREIGHG
410 420 430 440 450
KLAWKAIHPV LPDKSEFPYT IRVVSEIMES DGSSSMATVC GTSIALMDTG
460 470 480 490 500
VPIKAPVAGI AMGLIKDKNE HIILSDILGD EDYLGDMDFK VAGTSEGITA
510 520 530 540 550
LQMDMKIPGI SFEIVEKSLE QAKVGRLHIL EKMNAVISEH RKDIKDHVPR
560 570 580 590 600
VLSFYIDKDK ISAAIGTKGK NIRSVCERSN AKIEIGDDGK VSVFAISSTE
610 620 630 640 650
AEAAKNMMID SITELEQGSI IDAKVVKIEK SIVELELLNG RKGKMHISEV
660 670 680 690 700
ANQHVESIED ILKQGDTFKA LIIDFEKGGC PKLSRRRVDQ ETGEFFEGKL
710 720 730 740 750
YNEERRDGLN NRDNYYNNSF NKKPEDNYHS NRPTRPRSGF SNRSRPKFGN

NDSSSGFY
Length:758
Mass (Da):84,663
Last modified:July 22, 2008 - v1
Checksum:i256402174A833358
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM999887 Genomic DNA. Translation: CAQ54939.1.
RefSeqiYP_001975589.1. NC_010981.1.

Genome annotation databases

EnsemblBacteriaiCAQ54939; CAQ54939; WP0831.
GeneIDi6384667.
KEGGiwpi:WPa_0831.
PATRICi24027348. VBIWolEnd95846_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM999887 Genomic DNA. Translation: CAQ54939.1 .
RefSeqi YP_001975589.1. NC_010981.1.

3D structure databases

ProteinModelPortali B3CM21.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 570417.WPa_0831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ54939 ; CAQ54939 ; WP0831 .
GeneIDi 6384667.
KEGGi wpi:WPa_0831.
PATRICi 24027348. VBIWolEnd95846_0913.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci WEND570417:GHSW-847-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: wPip.

Entry informationi

Entry nameiPNP_WOLPP
AccessioniPrimary (citable) accession number: B3CM21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3