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B3CM21

- PNP_WOLPP

UniProt

B3CM21 - PNP_WOLPP

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, WP0831
Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi482 – 4821Magnesium By similarity
Metal bindingi488 – 4881Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciWEND570417:GHSW-847-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:WP0831
OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
Taxonomic identifieri570417 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008814: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000192505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi570417.WPa_0831.

Structurei

3D structure databases

ProteinModelPortaliB3CM21.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 60860KH
Add
BLAST
Domaini618 – 68669S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3CM21-1 [UniParc]FASTAAdd to Basket

« Hide

MFEIIKKSID WEGRTLSLET GKIARQADGS VVVNYGDTSI LVTVVRKKKE    50
ESVDFLPLNV QFIAKSYAMG KIPGGFFKRE GKPSDRETLI SRVIDRSIRP 100
LFPEGFHDEI SVVCNLLTYD TVNSPEVPAL IGTVAALAIS GVPFHFTIAG 150
VMVGCDENNN YILNPSVQEM KASNLDLFLS GDENSILMVE SEVKELSEEN 200
VLNAIKFGHE HLQPVIKLIK EFADTVGNKP ESFAPVDISD ITQELEKYRK 250
DFEEAYSKTV KQERVQALEV VRNNILNTLK EAGKDEKLIT YAVKSFERSL 300
VREMIRRKSV RIDSRKYDEI RQIEIEADIL PKTHGSALFT RGSTQALVVT 350
ALGTTQDEQI VDDIEGDRRE HFMLHYNFPP FAVGEASAIR APGRREIGHG 400
KLAWKAIHPV LPDKSEFPYT IRVVSEIMES DGSSSMATVC GTSIALMDTG 450
VPIKAPVAGI AMGLIKDKNE HIILSDILGD EDYLGDMDFK VAGTSEGITA 500
LQMDMKIPGI SFEIVEKSLE QAKVGRLHIL EKMNAVISEH RKDIKDHVPR 550
VLSFYIDKDK ISAAIGTKGK NIRSVCERSN AKIEIGDDGK VSVFAISSTE 600
AEAAKNMMID SITELEQGSI IDAKVVKIEK SIVELELLNG RKGKMHISEV 650
ANQHVESIED ILKQGDTFKA LIIDFEKGGC PKLSRRRVDQ ETGEFFEGKL 700
YNEERRDGLN NRDNYYNNSF NKKPEDNYHS NRPTRPRSGF SNRSRPKFGN 750
NDSSSGFY 758
Length:758
Mass (Da):84,663
Last modified:July 22, 2008 - v1
Checksum:i256402174A833358
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM999887 Genomic DNA. Translation: CAQ54939.1.
RefSeqiYP_001975589.1. NC_010981.1.

Genome annotation databases

EnsemblBacteriaiCAQ54939; CAQ54939; WP0831.
GeneIDi6384667.
KEGGiwpi:WPa_0831.
PATRICi24027348. VBIWolEnd95846_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM999887 Genomic DNA. Translation: CAQ54939.1 .
RefSeqi YP_001975589.1. NC_010981.1.

3D structure databases

ProteinModelPortali B3CM21.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 570417.WPa_0831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ54939 ; CAQ54939 ; WP0831 .
GeneIDi 6384667.
KEGGi wpi:WPa_0831.
PATRICi 24027348. VBIWolEnd95846_0913.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci WEND570417:GHSW-847-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: wPip.

Entry informationi

Entry nameiPNP_WOLPP
AccessioniPrimary (citable) accession number: B3CM21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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