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B3CLU1 (HEMH_WOLPP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:WP0751
OrganismWolbachia pipientis subsp. Culex pipiens (strain wPip) [Complete proteome] [HAMAP]
Taxonomic identifier570417 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Ferrochelatase HAMAP MF_00323
PRO_1000116089

Sites

Metal binding1901Iron By similarity
Metal binding2701Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B3CLU1 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: DF69E8F550217990

FASTA31736,383
        10         20         30         40         50         60 
MKKAVILFNL GGPDSLSAVR PFLFNLFYDK RIINLPNPFR FLLAKFISKR RESTAQEIYE 

        70         80         90        100        110        120 
HIGGKSPILE NTKAQADALE LKLNENGNHV YKIFICMRYW HPFADEVVKS VKQFDPDEII 

       130        140        150        160        170        180 
LLPLYPQYST TTTLSSIENW QKNAKLECNT KTIHHYYDNE DFIEAHVNLT SKYYKLASKI 

       190        200        210        220        230        240 
GKPRVLFSAH SLPLSIIKKG DPYASQIEKT VKLIVKKLNI EDLDWGICYQ SKVGPVKWLE 

       250        260        270        280        290        300 
PSTESELSRA KDDNIPVVLS PISFVSEHSE TLVELDIEYK AIIKDGYYFR VPTLSTDLLF 

       310 
IKCLADLCLD HSQSTDL

« Hide

References

[1]"Genome evolution of Wolbachia strain wPip from the Culex pipiens group."
Klasson L., Walker T., Sebaihia M., Sanders M.J., Quail M.A., Lord A., Sanders S., Earl J., O'Neill S.L., Thomson N., Sinkins S.P., Parkhill J.
Mol. Biol. Evol. 25:1877-1887(2008) [PubMed: 18550617] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: wPip.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM999887 Genomic DNA. Translation: CAQ54859.1.
RefSeqYP_001975511.1. NC_010981.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB3CLU1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBWOLT00000001133; EBWOLP00000001133; EBWOLG00000001133.
GeneID6384964.
GenomeReviewsGene locus WP0751 in contig AM999887_GR.
KEGGwpi:WPa_0751.
PATRIC24027178. VBIWolEnd95846_0830.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000031382.
HOGENOMHBG697135.
OMALLQMGGP.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_WOLPP
AccessionPrimary (citable) accession number: B3CLU1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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