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B3CLT1

- SYL_WOLPP

UniProt

B3CLT1 - SYL_WOLPP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei589 – 5891ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciWEND570417:GHSW-755-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:WP0741
    OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
    Taxonomic identifieri570417 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000008814: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Leucine--tRNA ligasePRO_1000091378Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi570417.WPa_0741.

    Structurei

    3D structure databases

    ProteinModelPortaliB3CLT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi586 – 5905"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3CLT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDFKNVEK FYQNKWDFSV SKDSKKKKCY VLEMFPYPSG KIHMGHLRNY    50
    AIGDVIARYK RARGFEVLHP IGWDAFGLPA ENAARDNNIN PAAWTQDNID 100
    NMRTQLKSIG LSYNWDRELS TCEPDYYKHE QKFFLDFLKH GLAYRKESWV 150
    NWDPVDQTVL ANEQVVDGKG WRSGAVVEKR KLFQWFLKIT DFAEDLLHCL 200
    QSLKNWPEKV KTMQERWIGK SEGATIDFEI FGLNKKLKIF TTSPHTLFGA 250
    SFLAVGAEHP IVQDLKDKEI RDFIGNMKAK GENDEKIGIY TGLNVKHPFL 300
    DKELPLYIAN FVLMEYGEGA IFGCPAHDQR DFEFAQKYGL PIIPVVCEES 350
    TEILKEPYFG DGVMFNSEFL NGLMINEAKK VIIKKLEEKG IGKKTINYRL 400
    HDWGISRQRY WGCPIPIIHC KDCGIVPVPE KDLPVVLPTD VEFTSGGNPL 450
    DKHPTWKFVD CPKCGKQAER ETDTFDTFFE SSWYFAAFCS ENKSINKDTC 500
    NRFMPVDYYI GGIEHAILHL LYSRFFCRAL TKCGYFDVKE PFSTLITQGM 550
    VCHITYKDEN GKWLFPEEAK ELIAKGAKIQ VGKVEKMSKS KKNTVDPNFI 600
    IEKYGADTAR LFVLSDTPPE KDMEWSDDGV EGCFRYINKL WRMVVQLRTV 650
    NIHYDNENIV GKLLEYRKKI HKLLHGLTDD LENCRLNCVV AKFREMTNLI 700
    AEIDVKTGKS LIDEGICILI RVIEPLMPHL AENLWQEIGG EGMLYMQPWP 750
    KADESLLIDN MVTVAVQING KLRATIKVET DLPQEELKKI ATDSVSNKID 800
    QSKIRTIYAV PNKVVNIVI 819
    Length:819
    Mass (Da):94,306
    Last modified:July 22, 2008 - v1
    Checksum:i5D9B6B6366227F7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM999887 Genomic DNA. Translation: CAQ54849.1.
    RefSeqiYP_001975501.1. NC_010981.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ54849; CAQ54849; WP0741.
    GeneIDi6384619.
    KEGGiwpi:WPa_0741.
    PATRICi24027156. VBIWolEnd95846_0819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM999887 Genomic DNA. Translation: CAQ54849.1 .
    RefSeqi YP_001975501.1. NC_010981.1.

    3D structure databases

    ProteinModelPortali B3CLT1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 570417.WPa_0741.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ54849 ; CAQ54849 ; WP0741 .
    GeneIDi 6384619.
    KEGGi wpi:WPa_0741.
    PATRICi 24027156. VBIWolEnd95846_0819.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci WEND570417:GHSW-755-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: wPip.

    Entry informationi

    Entry nameiSYL_WOLPP
    AccessioniPrimary (citable) accession number: B3CLT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3