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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei589ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:WP0741
OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
Taxonomic identifieri570417 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000008814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913781 – 819Leucine--tRNA ligaseAdd BLAST819

Proteomic databases

PRIDEiB3CLT1

Interactioni

Protein-protein interaction databases

STRINGi570417.WPa_0741

Structurei

3D structure databases

ProteinModelPortaliB3CLT1
SMRiB3CLT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi586 – 590"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B3CLT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFKNVEK FYQNKWDFSV SKDSKKKKCY VLEMFPYPSG KIHMGHLRNY
60 70 80 90 100
AIGDVIARYK RARGFEVLHP IGWDAFGLPA ENAARDNNIN PAAWTQDNID
110 120 130 140 150
NMRTQLKSIG LSYNWDRELS TCEPDYYKHE QKFFLDFLKH GLAYRKESWV
160 170 180 190 200
NWDPVDQTVL ANEQVVDGKG WRSGAVVEKR KLFQWFLKIT DFAEDLLHCL
210 220 230 240 250
QSLKNWPEKV KTMQERWIGK SEGATIDFEI FGLNKKLKIF TTSPHTLFGA
260 270 280 290 300
SFLAVGAEHP IVQDLKDKEI RDFIGNMKAK GENDEKIGIY TGLNVKHPFL
310 320 330 340 350
DKELPLYIAN FVLMEYGEGA IFGCPAHDQR DFEFAQKYGL PIIPVVCEES
360 370 380 390 400
TEILKEPYFG DGVMFNSEFL NGLMINEAKK VIIKKLEEKG IGKKTINYRL
410 420 430 440 450
HDWGISRQRY WGCPIPIIHC KDCGIVPVPE KDLPVVLPTD VEFTSGGNPL
460 470 480 490 500
DKHPTWKFVD CPKCGKQAER ETDTFDTFFE SSWYFAAFCS ENKSINKDTC
510 520 530 540 550
NRFMPVDYYI GGIEHAILHL LYSRFFCRAL TKCGYFDVKE PFSTLITQGM
560 570 580 590 600
VCHITYKDEN GKWLFPEEAK ELIAKGAKIQ VGKVEKMSKS KKNTVDPNFI
610 620 630 640 650
IEKYGADTAR LFVLSDTPPE KDMEWSDDGV EGCFRYINKL WRMVVQLRTV
660 670 680 690 700
NIHYDNENIV GKLLEYRKKI HKLLHGLTDD LENCRLNCVV AKFREMTNLI
710 720 730 740 750
AEIDVKTGKS LIDEGICILI RVIEPLMPHL AENLWQEIGG EGMLYMQPWP
760 770 780 790 800
KADESLLIDN MVTVAVQING KLRATIKVET DLPQEELKKI ATDSVSNKID
810
QSKIRTIYAV PNKVVNIVI
Length:819
Mass (Da):94,306
Last modified:July 22, 2008 - v1
Checksum:i5D9B6B6366227F7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM999887 Genomic DNA Translation: CAQ54849.1
RefSeqiWP_012481901.1, NC_010981.1

Genome annotation databases

EnsemblBacteriaiCAQ54849; CAQ54849; WP0741
GeneIDi33019400
KEGGiwpi:WP0741

Similar proteinsi

Entry informationi

Entry nameiSYL_WOLPP
AccessioniPrimary (citable) accession number: B3CLT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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