B3CLR5 (SURE_WOLPP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	WP0725

Organism

Wolbachia pipientis subsp. Culex pipiens (strain wPip) [Complete proteome] [HAMAP]

Taxonomic identifier

570417 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	5'-nucleotidase surE HAMAP MF_00060		PRO_1000092046
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	40	1	Divalent metal cation By similarity
	Metal binding	94	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3CLR5 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 4101D98E5846EEEB	FASTA	256	27,857
	10 20 30 40 50 60 MIILITNDDG FESEGIRLLK EIAQNFASEV WIVAPDADRS GAARSLDYPV KQFIKISQHS 70 80 90 100 110 120 EREFSVSGTP ADCVIIALNK IMNKKPDLIL SGVNIGSNVG DDICYSGTIG AAMEGAARSI 130 140 150 160 170 180 PSIALSQVYH DKIDWNNTKI FAPKVIAKLM KVGWPKDIVM SINFPATEKV KGVEFAEQGE 190 200 210 220 230 240 YNIDGDLTFT ENLNGSLSLN WSREHSGSGS VDKIKGGFIT ITPIKLDFTD YDILNAMKNS 250 CAEEFSSIAN TPIASD

References

[1]

"Genome evolution of Wolbachia strain wPip from the Culex pipiens group." Klasson L., Walker T., Sebaihia M., Sanders M.J., Quail M.A., Lord A., Sanders S., Earl J., O'Neill S.L., Thomson N., Sinkins S.P., Parkhill J. Mol. Biol. Evol. 25:1877-1887(2008) [PubMed: 18550617] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: wPip.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM999887 Genomic DNA. Translation: CAQ54833.1.
RefSeq	YP_001975485.1. NC_010981.1.
3D structure databases
ProteinModelPortal	B3CLR5.
ModBase	Search...
Protein-protein interaction databases
STRING	B3CLR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBWOLT00000000677; EBWOLP00000000677; EBWOLG00000000677.
GeneID	6384713.
GenomeReviews	Gene locus WP0725 in contig AM999887_GR.
KEGG	wpi:WPa_0725.
PATRIC	24027122. VBIWolEnd95846_0802.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000030883.
HOGENOM	HBG600532.
OMA	MEGAARS.
ProtClustDB	CLSK740019.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_WOLPP

Accession

Primary (citable) accession number: B3CLR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program