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B3A0N5

- APY_TABYA

UniProt

B3A0N5 - APY_TABYA

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Protein
Apyrase
Gene
N/A
Organism
Tabanus yao (Horsefly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host. Shows potential for antithrombotic activity. May reduce probing time by facilitating the speed of locating blood.1 Publication

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Divalent metal cations By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi43 – 431Divalent metal cation 1 By similarityBy similarity
Metal bindingi45 – 451Divalent metal cation 1 By similarityBy similarity
Metal bindingi92 – 921Divalent metal cation 1 By similarityBy similarity
Metal bindingi92 – 921Divalent metal cation 2 By similarityBy similarity
Metal bindingi124 – 1241Divalent metal cation 2 By similarityBy similarity
Sitei125 – 1251Transition state stabilizer By similarityBy similarity
Sitei128 – 1281Transition state stabilizer By similarityBy similarity
Metal bindingi224 – 2241Divalent metal cation 2 By similarityBy similarity
Metal bindingi248 – 2481Divalent metal cation 2 By similarityBy similarity
Binding sitei418 – 4181Substrate By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrolase activity, acting on ester bonds Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. nucleotide catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apyrase (EC:3.6.1.5)
Alternative name(s):
ATP-diphosphatase
Short name:
ADPase
ATP-diphosphohydrolase
Adenosine diphosphatase
Allergen: Tab y 1
OrganismiTabanus yao (Horsefly)
Taxonomic identifieri485572 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraTabanomorphaTabanoideaTabanidaeTabanus

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei9494. Tab y 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 554533Apyrase
PRO_0000414929Add
BLAST

Expressioni

Tissue specificityi

Salivary gland specific.1 Publication

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni504 – 5107Substrate binding By similarityBy similarity

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProiIPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3A0N5-1 [UniParc]FASTAAdd to Basket

« Hide

MFKITVFIYV LQLILPSKVH SSPVPDSDNG LREFPLSIVH INDFHARFEQ    50
TDELGGQCKP TAKCVGGYAR LVTTVKKLKE EGQNTIFLNA ADNYQGTLWY 100
NLGKWNVTAY FMNLLPADAM TLGNHEFDDK IEGIVPFLEV IKTPIVVANI 150
DDSLEPTFKG KYTKSVVLER GGRKIGIVGV IAQNTDNISS PGKLRFLDEI 200
QSVKNESKRL REEEKVDIVI VLSHIGLDHD YDLAEQAGDY IDAIIGGHSH 250
SFLWTGDNPP GKEKVVDAYP VEIVQTSGKK VLIVQASAFA RYVGNITLYF 300
GENNNLIRYA GAPVYLDSDV PEVPQIVEEM KAWEEFVHEK GNEIIAESRV 350
VLSRENCRVS DCNIGNFFTD AYVHEYVTSH TGPYWTPVSV GLMNVGGIRA 400
SVDRGNITFS QLITMAPFEN TVDTFDLSGK HLLEAFEHAV TVPNRLGFNG 450
QNMLQVSGVK LVYDVTKCEG QRVVSAKIRC QKCDIPKYEP LDPEETYRIV 500
TASFLANGGD GFTMIRDNKK NYKVGRKDYD VLINYAKYSS PITIGEEGRI 550
RIIQ 554
Length:554
Mass (Da):61,880
Last modified:January 25, 2012 - v1
Checksum:i99E4B3B04F38EF59
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti444 – 4441N → K AA sequence 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...

Protein family/group databases

Allergomei 9494. Tab y 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProi IPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
PANTHERi PTHR11575. PTHR11575. 1 hit.
Pfami PF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR01607. APYRASEFAMLY.
SUPFAMi SSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEi PS00785. 5_NUCLEOTIDASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel allergen Tab y 1 with inhibitory activity of platelet aggregation from salivary glands of horseflies."
    An S., Ma D., Wei J.F., Yang X., Yang H.W., Yang H., Xu X., He S., Lai R.
    Allergy 66:1420-1427(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 78-104; 143-159; 175-192; 292-308; 431-444 AND 538-549, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN.
    Tissue: Salivary gland.

Entry informationi

Entry nameiAPY_TABYA
AccessioniPrimary (citable) accession number: B3A0N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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