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Protein

Apyrase

Gene
N/A
Organism
Tabanus yao (Horsefly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host. Shows potential for antithrombotic activity. May reduce probing time by facilitating the speed of locating blood.1 Publication

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

a divalent metal cationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43Divalent metal cation 1By similarity1
Metal bindingi45Divalent metal cation 1By similarity1
Metal bindingi92Divalent metal cation 1By similarity1
Metal bindingi92Divalent metal cation 2By similarity1
Metal bindingi124Divalent metal cation 2By similarity1
Sitei125Transition state stabilizerBy similarity1
Sitei128Transition state stabilizerBy similarity1
Metal bindingi224Divalent metal cation 2By similarity1
Metal bindingi248Divalent metal cation 2By similarity1
Binding sitei418SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apyrase1 Publication (EC:3.6.1.5By similarity)
Alternative name(s):
ATP-diphosphataseBy similarity
Short name:
ADPaseBy similarity
ATP-diphosphohydrolaseBy similarity
Adenosine diphosphataseBy similarity
Allergen: Tab y 11 Publication
OrganismiTabanus yao (Horsefly)
Taxonomic identifieri485572 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraTabanomorphaTabanoideaTabanidaeTabanus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei9494. Tab y 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000041492922 – 554ApyraseSequence analysisAdd BLAST533

Expressioni

Tissue specificityi

Salivary gland specific.1 Publication

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni504 – 510Substrate bindingBy similarity7

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProiIPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3A0N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKITVFIYV LQLILPSKVH SSPVPDSDNG LREFPLSIVH INDFHARFEQ
60 70 80 90 100
TDELGGQCKP TAKCVGGYAR LVTTVKKLKE EGQNTIFLNA ADNYQGTLWY
110 120 130 140 150
NLGKWNVTAY FMNLLPADAM TLGNHEFDDK IEGIVPFLEV IKTPIVVANI
160 170 180 190 200
DDSLEPTFKG KYTKSVVLER GGRKIGIVGV IAQNTDNISS PGKLRFLDEI
210 220 230 240 250
QSVKNESKRL REEEKVDIVI VLSHIGLDHD YDLAEQAGDY IDAIIGGHSH
260 270 280 290 300
SFLWTGDNPP GKEKVVDAYP VEIVQTSGKK VLIVQASAFA RYVGNITLYF
310 320 330 340 350
GENNNLIRYA GAPVYLDSDV PEVPQIVEEM KAWEEFVHEK GNEIIAESRV
360 370 380 390 400
VLSRENCRVS DCNIGNFFTD AYVHEYVTSH TGPYWTPVSV GLMNVGGIRA
410 420 430 440 450
SVDRGNITFS QLITMAPFEN TVDTFDLSGK HLLEAFEHAV TVPNRLGFNG
460 470 480 490 500
QNMLQVSGVK LVYDVTKCEG QRVVSAKIRC QKCDIPKYEP LDPEETYRIV
510 520 530 540 550
TASFLANGGD GFTMIRDNKK NYKVGRKDYD VLINYAKYSS PITIGEEGRI

RIIQ
Length:554
Mass (Da):61,880
Last modified:January 25, 2012 - v1
Checksum:i99E4B3B04F38EF59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti444N → K AA sequence (PubMed:21848516).1 Publication1

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei9494. Tab y 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProiIPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPY_TABYA
AccessioniPrimary (citable) accession number: B3A0N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: November 30, 2016
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.