SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B3A0L4

- LAC1_HERCO

UniProt

B3A0L4 - LAC1_HERCO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Laccase
Gene
N/A
Organism
Hericium coralloides (Coral tooth fungus) (Hericium ramosum)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products. Has activity towards ABTS and, to a much lesser extent, towards N,N-dimethyl-1,4-phenylenediamine, catechol and 2-methylcatechol.1 Publication

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.1 Publication

Cofactori

Binds 4 copper ions per monomer By similarity.By similarity

Enzyme regulationi

Strongly activated by Mg2+ and Al3+. At concentrations <50mM, activated by Ca2+, Mn2+, Co2+ and K+. Strongly inhibited by Hg2+ and, in a concentration-dependent manner, by Fe2+.1 Publication

pH dependencei

Optimum pH is 2.2. Activity declines sharply with decreases or increases in pH and is absent above pH 6.6.1 Publication

Temperature dependencei

Optimum temperature is 40 degrees Celsius. Retains 65% activity at 20 degrees Celsius and 24% activity at 100 degrees Celsius.

GO - Molecular functioni

  1. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17210.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase
Diphenol oxidase
Urishiol oxidase
OrganismiHericium coralloides (Coral tooth fungus) (Hericium ramosum)
Taxonomic identifieri100756 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesRussulalesHericiaceaeHericium

Subcellular locationi

Secreted By similarity By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›10›10Laccase
PRO_0000414619

Sequencei

Sequence statusi: Fragment.

B3A0L4-1 [UniParc]FASTAAdd to Basket

« Hide

AVGDDTPQLY                                               10
Length:10
Mass (Da):1,078
Last modified:December 14, 2011 - v1
Checksum:i228933C771AAAAA8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei10 – 101

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17210.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of a novel laccase from the edible mushroom Hericium coralloides."
    Zou Y.J., Wang H.X., Ng T.B., Huang C.Y., Zhang J.X.
    J. Microbiol. 50:72-78(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
    Tissue: Fruiting body.

Entry informationi

Entry nameiLAC1_HERCO
AccessioniPrimary (citable) accession number: B3A0L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 26, 2013
This is version 4 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibits HIV-1 reverse transcriptase (IC50=0.6 µM).1 Publication

Keywords - Technical termi

Direct protein sequencing

External Data

Dasty 3