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Protein

Laccase

Gene
N/A
Organism
Hericium coralloides (Coral tooth fungus) (Hericium ramosum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products. Has activity towards ABTS and, to a much lesser extent, towards N,N-dimethyl-1,4-phenylenediamine, catechol and 2-methylcatechol.1 Publication

Miscellaneous

Inhibits HIV-1 reverse transcriptase (IC50=0.6 µM).1 Publication

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.1 Publication

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Enzyme regulationi

Strongly activated by Mg2+ and Al3+. At concentrations <50 mM, activated by Ca2+, Mn2+, Co2+ and K+. Strongly inhibited by Hg2+ and, in a concentration-dependent manner, by Fe2+.1 Publication

pH dependencei

Optimum pH is 2.2. Activity declines sharply with decreases or increases in pH and is absent above pH 6.6.1 Publication

Temperature dependencei

Optimum temperature is 40 degrees Celsius. Retains 65% activity at 20 degrees Celsius and 24% activity at 100 degrees Celsius.1 Publication

GO - Molecular functioni

  • hydroquinone:oxygen oxidoreductase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • lignin catabolic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17210.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase1 Publication (EC:1.10.3.21 Publication)
Alternative name(s):
Benzenediol:oxygen oxidoreductaseBy similarity
Diphenol oxidaseBy similarity
Urishiol oxidaseBy similarity
OrganismiHericium coralloides (Coral tooth fungus) (Hericium ramosum)
Taxonomic identifieri100756 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesRussulalesHericiaceaeHericium

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004146191 – ›10Laccase›10

Sequencei

Sequence statusi: Fragment.

Length:10
Mass (Da):1,078
Last modified:December 14, 2011 - v1
Checksum:i228933C771AAAAA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei101 Publication1

Entry informationi

Entry nameiLAC1_HERCO
AccessioniPrimary (citable) accession number: B3A0L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: January 20, 2016
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing