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B3A0L4

- LAC1_HERCO

UniProt

B3A0L4 - LAC1_HERCO

Protein

Laccase

Gene
N/A
Organism
Hericium coralloides (Coral tooth fungus) (Hericium ramosum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Lignin degradation and detoxification of lignin-derived products. Has activity towards ABTS and, to a much lesser extent, towards N,N-dimethyl-1,4-phenylenediamine, catechol and 2-methylcatechol.1 Publication

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.1 Publication

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Enzyme regulationi

    Strongly activated by Mg2+ and Al3+. At concentrations <50mM, activated by Ca2+, Mn2+, Co2+ and K+. Strongly inhibited by Hg2+ and, in a concentration-dependent manner, by Fe2+.1 Publication

    pH dependencei

    Optimum pH is 2.2. Activity declines sharply with decreases or increases in pH and is absent above pH 6.6.1 Publication

    Temperature dependencei

    Optimum temperature is 40 degrees Celsius. Retains 65% activity at 20 degrees Celsius and 24% activity at 100 degrees Celsius.1 Publication

    GO - Molecular functioni

    1. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17210.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase1 Publication (EC:1.10.3.21 Publication)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductaseBy similarity
    Diphenol oxidaseBy similarity
    Urishiol oxidaseBy similarity
    OrganismiHericium coralloides (Coral tooth fungus) (Hericium ramosum)
    Taxonomic identifieri100756 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesRussulalesHericiaceaeHericium

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›10›10LaccasePRO_0000414619

    Sequencei

    Sequence statusi: Fragment.

    B3A0L4-1 [UniParc]FASTAAdd to Basket

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    AVGDDTPQLY                                               10
    Length:10
    Mass (Da):1,078
    Last modified:December 14, 2011 - v1
    Checksum:i228933C771AAAAA8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei10 – 1011 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17210.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Purification and characterization of a novel laccase from the edible mushroom Hericium coralloides."
      Zou Y.J., Wang H.X., Ng T.B., Huang C.Y., Zhang J.X.
      J. Microbiol. 50:72-78(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
      Tissue: Fruiting body1 Publication.

    Entry informationi

    Entry nameiLAC1_HERCO
    AccessioniPrimary (citable) accession number: B3A0L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 5 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Inhibits HIV-1 reverse transcriptase (IC50=0.6 µM).1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    External Data

    Dasty 3