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B3A003

- LYS3_CRAVI

UniProt

B3A003 - LYS3_CRAVI

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Protein
Lysozyme 3
Gene
lysoz3
Organism
Crassostrea virginica (Eastern oyster)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Has antibacterial activity.1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.1 Publication

pH dependencei

Optimum pH is 7.5-8.5.1 Publication

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme 3 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase 3
cv-lysozyme 3
Gene namesi
Name:lysoz3
OrganismiCrassostrea virginica (Eastern oyster)
Taxonomic identifieri6565 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

Subcellular locationi

Secreted By similarity By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 Publication
Add
BLAST
Chaini19 – 187169Lysozyme 31 Publication
PRO_0000374069Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB3A003.

Family & Domainsi

Sequence similaritiesi

Belongs to the lysozyme type I family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR006080. Defensin_beta/neutrophil.
IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3A003-1 [UniParc]FASTAAdd to Basket

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MNGLFLFCVA TTAALAYGSD APCTNSGGVC QDDHLACHNG HYQSGLCTGG    50
AHRRCCLTSA SHTGSFSTGI VSQQCLQCIC NVESGCKAIG CHFDVNSDSC 100
GYFQIKEGYW HDCGSPGSSW RSCANDLACA SKCVQAYMSR YIGFSGCSHS 150
CESYARIHNG GPAGCKHTNT LGYWSHVHAQ GCSHNSK 187
Length:187
Mass (Da):19,775
Last modified:July 22, 2008 - v1
Checksum:i688F67BD2DB2B2A5
GO

Mass spectrometryi

Molecular mass is 17782.33 Da from positions 19 - 187. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB427186 mRNA. Translation: BAG41979.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB427186 mRNA. Translation: BAG41979.1 .

3D structure databases

ProteinModelPortali B3A003.
ModBasei Search...

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR006080. Defensin_beta/neutrophil.
IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
PANTHERi PTHR11195. PTHR11195. 1 hit.
Pfami PF05497. Destabilase. 1 hit.
[Graphical view ]
SMARTi SM00048. DEFSN. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Lysozyme 3 gene in the eastern oyster, Crassostrea virginica."
    Itoh N., Xue Q.-G., Schey K.L., Cooper R.K., La Peyre J.F.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cv-lysozyme 3, further evidence of adaptive evolution of i-type lysozymes for nutrition in the eastern oyster."
    Xue Q.-G., Itoh N., Schey K.L., Li Y., Cooper R.K., La Peyre J.F.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 19-53 AND 55-186, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MASS SPECTROMETRY.
    Tissue: Digestive gland.

Entry informationi

Entry nameiLYS3_CRAVI
AccessioniPrimary (citable) accession number: B3A003
Secondary accession number(s): P85518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 22, 2008
Last modified: October 16, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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