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Protein

Lysozyme 3

Gene

lysoz3

Organism
Crassostrea virginica (Eastern oyster)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has antibacterial activity.1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.1 Publication

pH dependencei

Optimum pH is 7.5-8.5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Proton donorBy similarity1
Active sitei94NucleophileBy similarity1
Binding sitei137SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme 3By similarityImported (EC:3.2.1.171 Publication)
Alternative name(s):
1,4-beta-N-acetylmuramidase 3By similarity
Invertebrate-type lysozyme 3Curated
cv-lysozyme 31 PublicationBy similarity
Gene namesi
Name:lysoz3Imported
OrganismiCrassostrea virginica (Eastern oyster)
Taxonomic identifieri6565 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000037406919 – 187Lysozyme 31 PublicationAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 151By similarity
Disulfide bondi78 ↔ 182By similarity
Disulfide bondi80 ↔ 86By similarity
Disulfide bondi91 ↔ 100By similarity
Disulfide bondi113 ↔ 133By similarity
Disulfide bondi123 ↔ 129By similarity
Disulfide bondi147 ↔ 165By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliB3A003.
SMRiB3A003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 112Substrate bindingBy similarity7
Regioni158 – 160Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the lysozyme type I family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiView protein in Pfam
PF05497. Destabilase. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3A003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGLFLFCVA TTAALAYGSD APCTNSGGVC QDDHLACHNG HYQSGLCTGG
60 70 80 90 100
AHRRCCLTSA SHTGSFSTGI VSQQCLQCIC NVESGCKAIG CHFDVNSDSC
110 120 130 140 150
GYFQIKEGYW HDCGSPGSSW RSCANDLACA SKCVQAYMSR YIGFSGCSHS
160 170 180
CESYARIHNG GPAGCKHTNT LGYWSHVHAQ GCSHNSK
Length:187
Mass (Da):19,775
Last modified:July 22, 2008 - v1
Checksum:i688F67BD2DB2B2A5
GO

Mass spectrometryi

Molecular mass is 17782.33 Da from positions 19 - 187. Determined by MALDI. Curated1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB427186 mRNA. Translation: BAG41979.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLYS3_CRAVI
AccessioniPrimary (citable) accession number: B3A003
Secondary accession number(s): P85518
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 22, 2008
Last modified: June 7, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families