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B3A003

- LYS3_CRAVI

UniProt

B3A003 - LYS3_CRAVI

Protein

Lysozyme 3

Gene

lysoz3

Organism
Crassostrea virginica (Eastern oyster)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Has antibacterial activity.1 Publication

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.1 Publication

    pH dependencei

    Optimum pH is 7.5-8.5.1 Publication

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW
    2. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme 3ImportedBy similarity (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase 3By similarity
    cv-lysozyme 3By similarity1 Publication
    Gene namesi
    Name:lysoz3Imported
    OrganismiCrassostrea virginica (Eastern oyster)
    Taxonomic identifieri6565 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 187169Lysozyme 31 PublicationPRO_0000374069Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliB3A003.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the lysozyme type I family.Sequence Analysis

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR006080. Defensin_beta/neutrophil.
    IPR008597. Destabilase.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PANTHERiPTHR11195. PTHR11195. 1 hit.
    PfamiPF05497. Destabilase. 1 hit.
    [Graphical view]
    SMARTiSM00048. DEFSN. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B3A003-1 [UniParc]FASTAAdd to Basket

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    MNGLFLFCVA TTAALAYGSD APCTNSGGVC QDDHLACHNG HYQSGLCTGG    50
    AHRRCCLTSA SHTGSFSTGI VSQQCLQCIC NVESGCKAIG CHFDVNSDSC 100
    GYFQIKEGYW HDCGSPGSSW RSCANDLACA SKCVQAYMSR YIGFSGCSHS 150
    CESYARIHNG GPAGCKHTNT LGYWSHVHAQ GCSHNSK 187
    Length:187
    Mass (Da):19,775
    Last modified:July 22, 2008 - v1
    Checksum:i688F67BD2DB2B2A5
    GO

    Mass spectrometryi

    Molecular mass is 17782.33 Da from positions 19 - 187. Determined by MALDI. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB427186 mRNA. Translation: BAG41979.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB427186 mRNA. Translation: BAG41979.1 .

    3D structure databases

    ProteinModelPortali B3A003.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR006080. Defensin_beta/neutrophil.
    IPR008597. Destabilase.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    PANTHERi PTHR11195. PTHR11195. 1 hit.
    Pfami PF05497. Destabilase. 1 hit.
    [Graphical view ]
    SMARTi SM00048. DEFSN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Lysozyme 3 gene in the eastern oyster, Crassostrea virginica."
      Itoh N., Xue Q.-G., Schey K.L., Cooper R.K., La Peyre J.F.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cv-lysozyme 3, further evidence of adaptive evolution of i-type lysozymes for nutrition in the eastern oyster."
      Xue Q.-G., Itoh N., Schey K.L., Li Y., Cooper R.K., La Peyre J.F.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 19-53 AND 55-186, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MASS SPECTROMETRY.
      Tissue: Digestive gland1 Publication.

    Entry informationi

    Entry nameiLYS3_CRAVI
    AccessioniPrimary (citable) accession number: B3A003
    Secondary accession number(s): P85518
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3