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Protein

Lysozyme 3

Gene

lysoz3

Organism
Crassostrea virginica (Eastern oyster)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has antibacterial activity.1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.1 Publication

pH dependencei

Optimum pH is 7.5-8.5.1 Publication

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme 3ImportedBy similarity (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase 3By similarity
cv-lysozyme 3By similarity1 Publication
Gene namesi
Name:lysoz3Imported
OrganismiCrassostrea virginica (Eastern oyster)
Taxonomic identifieri6565 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 187169Lysozyme 31 PublicationPRO_0000374069Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB3A003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lysozyme type I family.Sequence Analysis

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR006080. Defensin_beta/neutrophil.
IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3A003-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGLFLFCVA TTAALAYGSD APCTNSGGVC QDDHLACHNG HYQSGLCTGG
60 70 80 90 100
AHRRCCLTSA SHTGSFSTGI VSQQCLQCIC NVESGCKAIG CHFDVNSDSC
110 120 130 140 150
GYFQIKEGYW HDCGSPGSSW RSCANDLACA SKCVQAYMSR YIGFSGCSHS
160 170 180
CESYARIHNG GPAGCKHTNT LGYWSHVHAQ GCSHNSK
Length:187
Mass (Da):19,775
Last modified:July 22, 2008 - v1
Checksum:i688F67BD2DB2B2A5
GO

Mass spectrometryi

Molecular mass is 17782.33 Da from positions 19 - 187. Determined by MALDI. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB427186 mRNA. Translation: BAG41979.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB427186 mRNA. Translation: BAG41979.1.

3D structure databases

ProteinModelPortaliB3A003.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR006080. Defensin_beta/neutrophil.
IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Lysozyme 3 gene in the eastern oyster, Crassostrea virginica."
    Itoh N., Xue Q.-G., Schey K.L., Cooper R.K., La Peyre J.F.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cv-lysozyme 3, further evidence of adaptive evolution of i-type lysozymes for nutrition in the eastern oyster."
    Xue Q.-G., Itoh N., Schey K.L., Li Y., Cooper R.K., La Peyre J.F.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 19-53 AND 55-186, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MASS SPECTROMETRY.
    Tissue: Digestive gland1 Publication.

Entry informationi

Entry nameiLYS3_CRAVI
AccessioniPrimary (citable) accession number: B3A003
Secondary accession number(s): P85518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 22, 2008
Last modified: January 7, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.