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B3A003 (LYS3_CRAVI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme 3

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase 3
cv-lysozyme 3
Gene names
Name:lysoz3
OrganismCrassostrea virginica (Eastern oyster)
Taxonomic identifier6565 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has antibacterial activity. Ref.2

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Ref.2

Subcellular location

Secreted By similarity UniProtKB P83673.

Sequence similarities

Belongs to the lysozyme type I family.

Biophysicochemical properties

pH dependence:

Optimum pH is 7.5-8.5. Ref.2

Mass spectrometry

Molecular mass is 17782.33 Da from positions 19 - 187. Determined by MALDI. Ref.2

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Bacteriolytic enzyme
Glycosidase
Hydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcytolysis

Inferred from electronic annotation. Source: UniProtKB-KW

defense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysozyme activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.2
Chain19 – 187169Lysozyme 3 Ref.2
PRO_0000374069

Sequences

Sequence LengthMass (Da)Tools
B3A003 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 688F67BD2DB2B2A5

FASTA18719,775
        10         20         30         40         50         60 
MNGLFLFCVA TTAALAYGSD APCTNSGGVC QDDHLACHNG HYQSGLCTGG AHRRCCLTSA 

        70         80         90        100        110        120 
SHTGSFSTGI VSQQCLQCIC NVESGCKAIG CHFDVNSDSC GYFQIKEGYW HDCGSPGSSW 

       130        140        150        160        170        180 
RSCANDLACA SKCVQAYMSR YIGFSGCSHS CESYARIHNG GPAGCKHTNT LGYWSHVHAQ 


GCSHNSK 

« Hide

References

[1]"Lysozyme 3 gene in the eastern oyster, Crassostrea virginica."
Itoh N., Xue Q.-G., Schey K.L., Cooper R.K., La Peyre J.F.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cv-lysozyme 3, further evidence of adaptive evolution of i-type lysozymes for nutrition in the eastern oyster."
Xue Q.-G., Itoh N., Schey K.L., Li Y., Cooper R.K., La Peyre J.F.
Submitted (MAR-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 19-53 AND 55-186, FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MASS SPECTROMETRY.
Tissue: Digestive gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB427186 mRNA. Translation: BAG41979.1.

3D structure databases

ProteinModelPortalB3A003.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR006080. Defensin_beta/neutrophil.
IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERPTHR11195. PTHR11195. 1 hit.
PfamPF05497. Destabilase. 1 hit.
[Graphical view]
SMARTSM00048. DEFSN. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYS3_CRAVI
AccessionPrimary (citable) accession number: B3A003
Secondary accession number(s): P85518
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 22, 2008
Last modified: October 16, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries