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Protein

G-protein coupled receptor 39

Gene

GPR39

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Zn2+ acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171ZincBy similarity
Metal bindingi19 – 191ZincBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 39
Gene namesi
Name:GPR39
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Transmembranei35 – 5521Helical; Name=1By similarityAdd
BLAST
Topological domaini56 – 6914CytoplasmicBy similarityAdd
BLAST
Transmembranei70 – 8920Helical; Name=2By similarityAdd
BLAST
Topological domaini90 – 10920ExtracellularBy similarityAdd
BLAST
Transmembranei110 – 13122Helical; Name=3By similarityAdd
BLAST
Topological domaini132 – 15120CytoplasmicBy similarityAdd
BLAST
Transmembranei152 – 17221Helical; Name=4By similarityAdd
BLAST
Topological domaini173 – 21745ExtracellularBy similarityAdd
BLAST
Transmembranei218 – 24225Helical; Name=5By similarityAdd
BLAST
Topological domaini243 – 28341CytoplasmicBy similarityAdd
BLAST
Transmembranei284 – 30522Helical; Name=6By similarityAdd
BLAST
Topological domaini306 – 32318ExtracellularBy similarityAdd
BLAST
Transmembranei324 – 34421Helical; Name=7By similarityAdd
BLAST
Topological domaini345 – 456112CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456G-protein coupled receptor 39PRO_0000379077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi11 ↔ 191PROSITE-ProRule annotation
Disulfide bondi108 ↔ 210PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence analysis
Modified residuei397 – 3971PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiB2ZHY2.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016648.

Structurei

3D structure databases

ProteinModelPortaliB2ZHY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077769.
InParanoidiB2ZHY2.
KOiK08412.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ZHY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSRPGND CSHVIDHSHV PEFEVATWIK ITLILLFLVI FVVGILGNSV
60 70 80 90 100
TIRVTQVLQK KGYLQKEVTD HMVSLACSDI LVFLIGMPVE FYSIIWNPLT
110 120 130 140 150
TPSYTVSCKL HSFLFETCSY ATLLHVLTLS FERYIAICHP FRYKAMSGPC
160 170 180 190 200
QVKLLIGFVW VTSTLVALPL LFAMGVEYPL VDVPSHRGLS CNRSRNHHSE
210 220 230 240 250
HPETSNMSVC TNLSSRWTVF QSSIFGAFII YLVVLVSVAF MCWSMMQALQ
260 270 280 290 300
RSKQGTLAAK GQQLQLRKSE SEESRSARRQ TIIFLRLIVV TLAICWMPNQ
310 320 330 340 350
IRRMMAAAKP KQDWTKAYFK AYMILLPFSD TFFYLSSVVN PLLYNVSSQQ
360 370 380 390 400
FRSVFAQVLR CRLTLPHANQ DKRLRAQAAS TMDSARSVHR PLIFLASRSN
410 420 430 440 450
SSARRTDKVF LSTSQSESEA KPQSKPQLLN HESPESDSVM KPANPATENG

IQEHEV
Length:456
Mass (Da):51,508
Last modified:July 1, 2008 - v1
Checksum:i5D74E484D7274D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU669821 mRNA. Translation: ACD39430.1.
RefSeqiNP_001121959.1. NM_001128487.1.
UniGeneiSsc.54396.
Ssc.80377.

Genome annotation databases

GeneIDi100158236.
KEGGissc:100158236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU669821 mRNA. Translation: ACD39430.1.
RefSeqiNP_001121959.1. NM_001128487.1.
UniGeneiSsc.54396.
Ssc.80377.

3D structure databases

ProteinModelPortaliB2ZHY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016648.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiB2ZHY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100158236.
KEGGissc:100158236.

Organism-specific databases

CTDi2863.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077769.
InParanoidiB2ZHY2.
KOiK08412.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and mRNA expression of G-protein coupled receptor 39 (GPR39) in Sus scrofa liver."
    Tang S.Q., Jiang Q.Y., Dong X.Y., Shu G., Zhang Y.L., Zhu X.T., Gao P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGPR39_PIG
AccessioniPrimary (citable) accession number: B2ZHY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 1, 2008
Last modified: July 6, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.